Ceroid granuloma of the uterine cervix

Eli Pikarsky, Pikarsky E, Bella Maly, Maly B, Alexander Maly, Maly A
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2002 · vol. 21(2) , pp. 191–3 · doi:10.1097/00004347-200204000-00014 · PMID:11917231
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This report describes a fourth case of ceroid granuloma in the uterine cervix, noting that while such lesions may be related to endometriosis, their rarity prevents definitive conclusions regarding etiology and pathogenesis.

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This case report describes a 58-year-old woman with an incidental, exophytic brownish lesion on the anterior cervical wall identified during routine examination. Histological analysis revealed sheets of ceroid-rich histiocytes within the superficial stroma without an obvious underlying cause, marking only the fourth documented instance in medical literature. The authors note that while these granulomas may be associated with endometriosis, the extreme rarity of cases prevents definitive conclusions regarding their etiology and pathogenesis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

A case of ceroid granuloma of the uterine cervix in a 58-year-old woman is presented, the fourth such case in the literature. It was an incidental finding during a routine pelvic examination and appeared as an exophytic brownish lesion on the anterior wall of the uterine cervix. On histological examination it consisted of sheets of ceroid-rich histiocytes within the superficial cervical stroma. There was no obvious cause for the lesion. Ceroid granulomas of the female genital tract may be related to endometriosis, but the rarity of the cases precludes definite conclusions about the etiology and pathogenesis of this lesion.
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Case Reports Ceroid Granuloma of the Uterine Cervix - Eli Pikarsky - Bella Maly - Alexander Maly International Journal of Gynecological Pathology 21(2):p 191-193, April 2002. Summary: A case of ceroid granuloma of the uterine cervix in a 58-year-old woman is presented, the fourth such case in the literature. It was an incidental finding during a routine pelvic examination and appeared as an exophytic brownish lesion on the anterior wall of the uterine cervix. On histological examination it consisted of sheets of ceroid-rich histiocytes within the superficial cervical stroma. There was no obvious cause for the lesion. Ceroid granulomas of the female genital tract may be related to endometriosis, but the rarity of the cases precludes definite conclusions about the etiology and pathogenesis of this lesion. Copyright ©2002International Society of Gynecological Pathologists

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Condition tags

endometriosis

MeSH descriptors

Ceroid Granuloma Uterine Cervical Diseases Ceroid Ceroid Female Female Granuloma Granuloma Granuloma Granuloma Humans Humans Immunohistochemistry Immunohistochemistry Middle Aged Middle Aged Uterine Cervical Diseases Uterine Cervical Diseases Uterine Cervical Diseases

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