Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E₂ production in human endometriotic stromal cells in spheroid culture

This doctoral research investigated the molecular mechanisms by which dienogest affects human endometriotic stromal cells using a three-dimensional spheroid culture system. The study demonstrated that treatment with dienogest significantly suppressed the expression of aromatase and cyclooxygenase-2 enzymes within these cells. Furthermore, the results indicated a marked reduction in prostaglandin E₂ production, suggesting a direct inhibitory effect on inflammatory pathways associated with the disease. This paper is centrally about endometriosis, specifically focusing on the pharmacological action of dienogest on endometriotic stromal cells to reduce key mediators of inflammation and estrogen synthesis.

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