Serum activity of matrix metalloproteinases-2 and-9

In: Bulletin of Experimental Biology and Medicine · 2006 · vol. 141(2) , pp. 247–249 · doi:10.1007/s10517-006-0140-1 · PMID:16984109 · W1977010329
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Serum activities of matrix metalloproteinases-2 and -9 are decreased in chronic endometritis associated with sterility, normalize after recovery, and may serve as markers for monitoring treatment efficiency.

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Abstract

Matrix metalloproteinases belong to the key effectors of tissue remodeling in health and disease. Matrix metalloproteinases -2 and -9, the most prevalent representatives of this family, are expressed in the endometrium. Chronic endometritis concomitant with sterility and spontaneous abortions is associated with decreased content of matrix metalloproteinases in the endometrium. Chronic endometritis combined with sterility correlates with decreased serum activities of matrix metalloproteinases -2 and -9, which returns to normal after recovery. Measurements of serum activities of matrix metalloproteinases -2 and -9 are proposed for monitoring of the dynamics and treatment efficiency in chronic endometritis.

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