Association Of The LH/FSH Ratio With Electrocardiogram Abnormalities In Polycystic Ovarian Syndrome

Association Of The LH/FSH Ratio With Electrocardiogram Abnormalities In Polycystic Ovarian Syndrome | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Association Of The LH/FSH Ratio With Electrocardiogram Abnormalities In Polycystic Ovarian Syndrome Lin Wu, Shuhui Zheng, Guangyin Zhao, Borui Tian, Yucong Sun, Ying Tan, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2141531/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: This study aimed to investigate the association of the Luteinizing/Follicle-stimulating hormone (LH/FSH) ratio with Electro-cardiogram (ECG) features in Polycystic Ovarian Syndrome (PCOS). Methods: Consecutive PCOS patients’ record were recruited from the database of the hospital for the cross-sectional study. Serum concentrations of testosterone, pituitary, prolactin, progesterone, estradiol, LH, and FSH were measure and 12-lead ECG was performed for each subject. According to LH/FSH ratio, subjects were divided into High Group (LH/FSH Ratio ≥ 2, n=24), and Low Group (LH/FSH Ratio < 2, n=52). 180 ECG features were automatically extracted by an ECG management system. The relationship between LH/FSH ratio and ECG variables was assessed by univariate and multivariate linear regression models. Results: 76 patients with PCOS were enrolled. The mean values of LH in High Group were significantly higher than that in Low Group (P < 0.0001). P wave changes, QRS duration and ST segment changes had significantly difference between the two groups. The beginning of P wave was lower in Lead I, aVL, V2, V5, V6 in High group. Compared to Low Group, QRS duration, R-Q interval and R-S interval was narrow in High Group. There were ST depression in High Group, especially in left precordial leads such as Lead I, aVL, V5 and V6. In PCOS patients, P wave, QRS duration and ST segment changes were the most abnormalities in ECG of High LH/FSH ratio Group. Conclusions: The associations between LH/FSH ratio and ECG abnormalities were enhanced by the increased risk stratification of PCOS patients. Polycystic Ovarian Syndrome (PCOS) Electrocardiogram (ECG) Luteinizing/Follicle-stimulating hormone (LH/FSH) ratio Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2141531","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":142727572,"identity":"2d27d5ce-ac47-4d87-83fe-869f1174e973","order_by":0,"name":"Lin Wu","email":"","orcid":"","institution":"The Third Affiliated Hospital of Sun Yat-sen University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lin","middleName":"","lastName":"Wu","suffix":""},{"id":142727573,"identity":"f5bd01b3-4bd7-4937-b5a9-7d29ed9b33d1","order_by":1,"name":"Shuhui Zheng","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBElEQVRIiWNgGAWjYDACCQY2BsYGGzkGBsbGAwhBwlrSjIFaGkjScjixAcgmTov87PZnj3l3MKevbT8MtOXPYXuDA8wHb/Mw2OXh0sI454y5Me8ZttxtZxIbDjC2HU7ccIAt2ZqHIbkYlxZmiRw2ad42ntxtB0BaGg4nGBzgMZPmYTgAdio2wCaR/gyoRSLd7PxDmMP4v+HVwiORYAbUYpBgdgNoCwPbYcYNB3jY8GqRkMgxk5zblmC47QbQlsS29MSZh9mMLecYJOPUIj8j/ZnE27b/8mbn0x8++PDH2p7vePPDG28q7HBqQQUJDM3AEAGxDIhSDwZ1xCsdBaNgFIyCEQMAzbBaeIYnbe4AAAAASUVORK5CYII=","orcid":"","institution":"The First Affiliated Hospital, Sun Yat-sen University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Shuhui","middleName":"","lastName":"Zheng","suffix":""},{"id":142727574,"identity":"e7f62c41-009a-459f-924b-f85eee471391","order_by":2,"name":"Guangyin Zhao","email":"","orcid":"","institution":"The First Affiliated Hospital, Sun Yat-sen 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University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yanming","middleName":"","lastName":"Chen","suffix":""}],"badges":[],"createdAt":"2022-10-07 09:29:37","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-2141531/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-2141531/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":27638446,"identity":"a24a6132-9b52-463d-acca-6e1a363d217b","added_by":"auto","created_at":"2022-10-11 18:47:45","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":694668,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2141531/v1_covered.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Association Of The LH/FSH Ratio With Electrocardiogram Abnormalities In Polycystic Ovarian Syndrome","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-2141531/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Polycystic Ovarian Syndrome (PCOS), Electrocardiogram (ECG), Luteinizing/Follicle-stimulating hormone (LH/FSH) ratio","lastPublishedDoi":"10.21203/rs.3.rs-2141531/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-2141531/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjective:\u003c/strong\u003e This study aimed to investigate the association of the Luteinizing/Follicle-stimulating hormone (LH/FSH) ratio with Electro-cardiogram (ECG) features in Polycystic Ovarian Syndrome (PCOS).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e Consecutive PCOS patients’ record were recruited from the database of the hospital for the cross-sectional study. Serum concentrations of testosterone, pituitary, prolactin, progesterone, estradiol, LH, and FSH were measure and 12-lead ECG was performed for each subject. According to LH/FSH ratio, subjects were divided into High Group (LH/FSH Ratio ≥ 2, n=24), and Low Group (LH/FSH Ratio \u0026lt; 2, n=52). 180 ECG features were automatically extracted by an ECG management system. The relationship between LH/FSH ratio and ECG variables was assessed by univariate and multivariate linear regression models.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e 76 patients with PCOS were enrolled. The mean values of LH in High Group were significantly higher than that in Low Group (P \u0026lt; 0.0001). P wave changes, QRS duration and ST segment changes had significantly difference between the two groups. The beginning of P wave was lower in Lead I, aVL, V2, V5, V6 in High group. Compared to Low Group, QRS duration, R-Q interval and R-S interval was narrow in High Group. There were ST depression in High Group, especially in left precordial leads such as Lead I, aVL, V5 and V6. In PCOS patients, P wave, QRS duration and ST segment changes were the most abnormalities in ECG of High LH/FSH ratio Group.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eThe associations between LH/FSH ratio and ECG abnormalities were enhanced by the increased risk stratification of PCOS patients.\u003c/p\u003e","manuscriptTitle":"Association Of The LH/FSH Ratio With Electrocardiogram Abnormalities In Polycystic Ovarian Syndrome","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-10-11 18:47:36","doi":"10.21203/rs.3.rs-2141531/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ba7eb9c3-8559-4ddf-b478-348067abbacb","owner":[],"postedDate":"October 11th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2022-12-08T03:59:14+00:00","versionOfRecord":[],"versionCreatedAt":"2022-10-11 18:47:36","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-2141531","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-2141531","identity":"rs-2141531","version":["v1"]},"buildId":"369fNeqWncA4NS6XSWjrt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}