Prevalence And Determinants Of Pulmonary Hypertension In Rheumatic Heart Disease Patients At University Of Gondar Comprehensive Specialized Hospital: A Retrospective study From 2018 to 2023.

Prevalence And Determinants Of Pulmonary Hypertension In Rheumatic Heart Disease Patients At University Of Gondar Comprehensive Specialized Hospital: A Retrospective study From 2018 to 2023. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Prevalence And Determinants Of Pulmonary Hypertension In Rheumatic Heart Disease Patients At University Of Gondar Comprehensive Specialized Hospital: A Retrospective study From 2018 to 2023. Fikadu Alemiye Molla, Desalew Getahun Ayalew, Hailemariyam Alemu Astatk, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4492463/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 18 Mar, 2025 Read the published version in BMC Cardiovascular Disorders → Version 1 posted 4 You are reading this latest preprint version Abstract Introduction: Most Rheumatic heart disease patients present with advanced disease and complications, pulmonary hypertension being one of the main complications. The presence of pulmonary hypertension is independently associated with increased pre-operative and perioperative morbidity and mortality in RHD patients. There are only few studies that showed the magnitude of pulmonary hypertension in RHD patients. This study was done to know the magnitude and predictors of PH in RHD patients so that early identification and intervention can be done for those at risk to develop PH. Methods An institution-based retrospective study was conducted by reviewing medical records of patients at adult echocardiographic unit from September, 2018 to September, 2023. Systolic PAP > 35mmHg using 2D echocardiography was used to diagnose pulmonary hypertension. Bi-variable logistic regression analysis followed by multivariable logistic regression analysis was done using SPSS statistics 25. P value < 0.05 and 95% CI was used to determine significant association. Result A total of 230 RHD patients were included during the study period between September 2018 and September 2023. Most patients were young below the age of 35 years (68.3%) with median age of 28 years and interquartile range of 21 to 38 years. Among the study participants 72.2% were females and 67% of them were rural residents. PH prevalence among RHD patients was found to be 77.4% (95% CI: 71.4%, 82.6%). Most patients (51.3%) had severe PH (≥ 60mmHg), whereas Mild PH (36–44mmHg) was 7.4% and moderate PH (45-59mmHg) was 18.7%. PH was found to have significant association with severe MS (AOR = 5.31, 95%CI: 1.87, 15.06), moderate to severe MR (AOR = 2.68, 95% CI: 1.05, 6.84), NYHA functional class III and IV (AOR = 2.60, 95% CI: 1.01, 6.68) and Diuretics use (AOR = 4.43, 95% CI: 1.33, 14.70). Conclusion The prevalence of PH among rheumatic heart disease patients in this study was high. Moderate to severe MR, severe MS, NYHA class III and IV, and diuretics use were significantly associated with PH. Expanding surgical intervention to address this patients is needed to decrease PH prevalence and morbidity and mortality associated with it. Rheumatic heart disease valvular heart disease Pulmonary hypertension Factors Prevalence Ethiopia Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 18 Mar, 2025 Read the published version in BMC Cardiovascular Disorders → Version 1 posted Editorial decision: Revision requested 18 Jun, 2024 Editor assigned by journal 18 Jun, 2024 Submission checks completed at journal 18 Jun, 2024 First submitted to journal 28 May, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4492463","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":316053994,"identity":"4582f992-123b-4997-91b1-871eaaab7eca","order_by":0,"name":"Fikadu Alemiye 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Disorders](http://bmccardiovascdisord.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcar/default.aspx","title":"BMC Cardiovascular Disorders","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Rheumatic heart disease, valvular heart disease, Pulmonary hypertension, Factors, Prevalence, Ethiopia","lastPublishedDoi":"10.21203/rs.3.rs-4492463/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4492463/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eIntroduction:\u003c/h2\u003e \u003cp\u003eMost Rheumatic heart disease patients present with advanced disease and complications, pulmonary hypertension being one of the main complications. The presence of pulmonary hypertension is independently associated with increased pre-operative and perioperative morbidity and mortality in RHD patients. There are only few studies that showed the magnitude of pulmonary hypertension in RHD patients. This study was done to know the magnitude and predictors of PH in RHD patients so that early identification and intervention can be done for those at risk to develop PH.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eAn institution-based retrospective study was conducted by reviewing medical records of patients at adult echocardiographic unit from September, 2018 to September, 2023. Systolic PAP\u0026thinsp;\u0026gt;\u0026thinsp;35mmHg using 2D echocardiography was used to diagnose pulmonary hypertension. Bi-variable logistic regression analysis followed by multivariable logistic regression analysis was done using SPSS statistics 25. P value\u0026thinsp;\u0026lt;\u0026thinsp;0.05 and 95% CI was used to determine significant association.\u003c/p\u003e\u003ch2\u003eResult\u003c/h2\u003e \u003cp\u003eA total of 230 RHD patients were included during the study period between September 2018 and September 2023. Most patients were young below the age of 35 years (68.3%) with median age of 28 years and interquartile range of 21 to 38 years. Among the study participants 72.2% were females and 67% of them were rural residents. PH prevalence among RHD patients was found to be 77.4% (95% CI: 71.4%, 82.6%). Most patients (51.3%) had severe PH (\u0026ge;\u0026thinsp;60mmHg), whereas Mild PH (36\u0026ndash;44mmHg) was 7.4% and moderate PH (45-59mmHg) was 18.7%. PH was found to have significant association with severe MS (AOR\u0026thinsp;=\u0026thinsp;5.31, 95%CI: 1.87, 15.06), moderate to severe MR (AOR\u0026thinsp;=\u0026thinsp;2.68, 95% CI: 1.05, 6.84), NYHA functional class III and IV (AOR\u0026thinsp;=\u0026thinsp;2.60, 95% CI: 1.01, 6.68) and Diuretics use (AOR\u0026thinsp;=\u0026thinsp;4.43, 95% CI: 1.33, 14.70).\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eThe prevalence of PH among rheumatic heart disease patients in this study was high. Moderate to severe MR, severe MS, NYHA class III and IV, and diuretics use were significantly associated with PH. Expanding surgical intervention to address this patients is needed to decrease PH prevalence and morbidity and mortality associated with it.\u003c/p\u003e","manuscriptTitle":"Prevalence And Determinants Of Pulmonary Hypertension In Rheumatic Heart Disease Patients At University Of Gondar Comprehensive Specialized Hospital: A Retrospective study From 2018 to 2023.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-07-04 16:47:35","doi":"10.21203/rs.3.rs-4492463/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-06-18T18:01:40+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-06-18T14:52:54+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-06-18T14:52:51+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Cardiovascular Disorders","date":"2024-05-28T17:20:19+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cardiovascular-disorders","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcar","sideBox":"Learn more about [BMC Cardiovascular Disorders](http://bmccardiovascdisord.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcar/default.aspx","title":"BMC Cardiovascular Disorders","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2beee450-8dad-4e26-8096-2017d58926a8","owner":[],"postedDate":"July 4th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-03-24T16:02:14+00:00","versionOfRecord":{"articleIdentity":"rs-4492463","link":"https://doi.org/10.1186/s12872-025-04648-1","journal":{"identity":"bmc-cardiovascular-disorders","isVorOnly":false,"title":"BMC Cardiovascular Disorders"},"publishedOn":"2025-03-18 15:57:50","publishedOnDateReadable":"March 18th, 2025"},"versionCreatedAt":"2024-07-04 16:47:35","video":"","vorDoi":"10.1186/s12872-025-04648-1","vorDoiUrl":"https://doi.org/10.1186/s12872-025-04648-1","workflowStages":[]},"version":"v1","identity":"rs-4492463","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4492463","identity":"rs-4492463","version":["v1"]},"buildId":"-HB7Z8yhvgn0wM9Nzuekk","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}