Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Immunity, Inflammation and Disease This is a preprint and has not been peer reviewed. Data may be preliminary. 14 July 2025 V1 Latest version Share on Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India Author : Abrar Ahmad Zargar 0000-0003-4649-2891 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175248757.74776152/v1 302 views 132 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chandipura virus (CHPV), an arbovirus belonging to genus Vesiculovirus in the family Rhabdoviridae has gained global attention as an encephalitis causing virus after the 2003-2004 outbreaks in central India. Transmitted by sandflies, particularly the female phlebotomine sandfly, CHPV is closely related to the Vesicular Stomatitis Virus but is distinguished by its ability to infect humans. The virus was first discovered in 1966 by researchers at the Virus Research Centre in Pune, India, during an investigation of febrile illnesses suspected to be caused by dengue or chikungunya viruses. However, CHPV’s public health importance was underscored only after a major outbreak of encephalitis with high case fatality rates among children in 2003. Clinically, CHPV infection manifests as a rapid-onset, severe illness characterized by high fever, abnormal sensory perception, and seizures, with an incubation period of just 24 to 48 hours. The virus’s ability to cause such severe symptoms and the speed of disease progression pose significant challenges for diagnosis and treatment. This review explores the origin, evolution, and transmission dynamics of CHPV, highlighting the role of sandflies as vectors and the impact of the virus on public health. The review also discusses the epidemiology of CHPV, including notable outbreaks, and the current understanding of its pathology and clinical manifestations. Given the ongoing threat posed by CHPV, there is a pressing need for enhanced surveillance, improved diagnostic methods, and the development of effective vaccines and treatment strategies to mitigate the impact of this emerging viral threat. Supplementary Material File (chandipura virus.docx) Download 4.52 MB Information & Authors Information Version history V1 Version 1 14 July 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Immunity, Inflammation and Disease Authors Affiliations Abrar Ahmad Zargar 0000-0003-4649-2891 [email protected] ISF College of Pharmacy View all articles by this author Metrics & Citations Metrics Article Usage 302 views 132 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Abrar Ahmad Zargar. 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