Clinic curative effects of low-dose mifepristone in treating recurrent endometriosis and changes in ovarian function and serum cortisol level

Objective To investigate the clinic curative effects,serum cortisol and ovarian function after treated with low-dose mifepristone following conservative surgery in recurrent endometriosis.Methods One hundred twenty-six patients with recurrent endometriosis after abdominoscope diagnosis were divided into M and D groups,the patients in group M (n=72)were treated orally with mifepristone and group D(n=54) with danazol,the symptoms,signs,ovarian function and changes in blood cortisol 3 months after treatment were observed. Results The differences of remission rates after treatment on symptoms, dysmenorrhea,hypogastralgia during non menstrual period,sexual intercourse pain,pelvic cavity tenderness,rear excavation tuberosity,womb movement restriction,aberrant ovary cyst size between two groups were not significant (P0.05).After treatment,blood serum E2 level in group M was (74.18±22.32) pmol·L-1,whereas that in group D was (24.96±3.94)pmol·L-1,there was significant difference(P0.01).The differences of blood serum cortisol level between two groups had no significant difference (P0.05).Conclusion Clinical symptoms of patients with recurrent endometriosis in two groups are improved.Serum E2 level in group M remains in the follicular phase,but group D declines to postmenopausal range.Mifepristone does not result in lack of estrogen,ovulation recovers rapidly after treatment in group M compared with group D.Mifepristone and danazol have not obvious impact on blood serum cortisol.