Genistein aglycone: A new therapeutic approach to reduce endometrial hyperplasia

Alessandra Bitto, Roberta Granese, Onofrio Triolo, Daniela Villari, D Maisano, Domenico Giordano, Domenica Altavilla, Herbert Marini, Elena Bianca Adamo, Piero Antonio Nicòtina, Rosario D’Anna, Francesco Squadrito
In: Phytomedicine · 2010 · vol. 17(11) , pp. 844–850 · doi:10.1016/j.phymed.2010.03.024 · PMID:20570122 · W1999262270
article OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-01 ⓘ

Genistein aglycone reduced endometrial hyperplasia symptoms and thickness, showing decreased ER-alpha and PR and increased ER-beta1 staining, comparable to progestin treatment.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveEndometrial hyperplasia without cytological atypia is commonly treated with progestins, but other treatment regimes may be available with equivalent efficacy and low side effects.DesignA randomized double-blind, placebo and progesterone-controlled clinical trial to evaluate the effects of genistein aglycone in reducing endometrial hyperplasia.PatientsA group of 56 premenopausal women with non-atypical endometrial hyperplasia were enrolled and received: genistein aglycone (n=19; 54 mg/day); norethisterone acetate (n=19; 10 mg/day on days 16-25 of the menstrual cycle) or placebo (n=18) for 6 months.MeasurementsHysteroscopy was performed with biopsies and symptomology assessed at baseline, 3 and 6 months of administration. The effect on estrogen (ER) and progesterone receptors (PR) expression in uterine biopsies were assessed after 3 and 6 months. For each treatment follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), sex hormone-binding globulin (SHBG) and progesterone (PG) levels were also evaluated.ResultsAfter 6 months, 42% of genistein aglycone-administered subjects had a significant improvement of symptoms (histologically confirmed in the 29%) compared to 47% of norethisterone acetate subjects (histologically confirmed in the 31%), but only 12% in the placebo group with 19% exhibiting worsening symptoms and increased endometrial thickness. No significant differences were noted for hormone levels for any treatment, but immunohistochemical analysis revealed significantly reduced staining for ER-alpha and PR and enhanced ER-beta1 staining in genistein-administered subjects associated with a complete regression of bleeding.ConclusionsThese results suggest that genistein aglycone might be useful for the management of endometrial hyperplasia without atypia in women that cannot be treated with progestin.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Cited by (1)

References (61)

Cited by (1)

Source provenance

openalex
last seen: 2026-05-11T06:40:38.933960+00:00
unpaywall
last seen: 2026-09-12T07:21:10.926195+00:00
License: CC0 · commercial use OK