Brain water interhemispheric balance assessed by fNIRS from frontal lobe provides separation between stroke patients and controls

Brain water interhemispheric balance assessed by fNIRS from frontal lobe provides separation between stroke patients and controls | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Brain water interhemispheric balance assessed by fNIRS from frontal lobe provides separation between stroke patients and controls Hany Ferdinando, Sadegh Moradi, Jari Paunonen, Mikael Fraunberg, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7081520/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Using functional near-infrared spectroscopy (fNIRS) to get stroke biomarkers so far only focuses on the hemodynamic response, which may be limited, while other modalities, e.g., MRI, have started to observe brain water. To the best of our knowledge, this is the first study of using fNIRS that utilised water fluctuation in the brain. In this present study, we investigated the interhemispheric balance of the brain water (including water in blood, brain tissue, and CSF) measured using a novel fNIRS device capable of sensing both water and blood volume dynamics. Measurement was performed from the prefrontal cortex area for 5 minutes while subjects were resting in a sitting position. The analysis relied on correlation between signals from left and right hemispheres in two bands of interest, i.e., respiratory (0.1-0·6 Hz) and cardiac (0.6-5 Hz) bands. This study involved 58 stroke patients (27 females, 67.7 ± 11.9 years old) and 33 controls (22 females, 69.4 ± 8.0 years old). Here, we show that the brain water provides good separation (p-value<0·001) between patients and controls, which may be related to the swelling caused by stroke; it is even better than relying on the hemodynamic response. Health sciences/Biomarkers/Diagnostic markers Health sciences/Medical research/Biomarkers/Diagnostic markers Full Text Additional Declarations There is NO Competing Interest. Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7081520","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":492730512,"identity":"d7adf2d8-3f60-4045-976c-9d966f07f2d7","order_by":0,"name":"Hany 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