Human Reproduction vol.1 no.5 pp.291-293, 1986 Early luteal function following danazol therapy for endometriosis

'To whom reprint requests should be sent The luteal phase of 20 infertile women with endometriosis who were treated with danazol (600 mg daily for 6 months) was studied by basal body temperature, plasma progesterone (P), oestradiol (Ej) and prolactin (PRL) determination, and en-dometrial biopsy, in any one of the first three cycles after discontinuation of danazol. All endometrial specimens were noted to be fundal samples and were clearly progestational after danazol therapy. Abnormal secretory phases were detected in three patients, as in the pre-danazoJ control cycles. Moreover, plasma levels of P, Ej and PRL in post-danazol cycles were similar to those found in control cycles and fell within the normal range in all cases except for one patient having hyperprolactinaemia. In conclusion, our study shows that endometrial inadequacy is not the cause of the increas-ed fetal wastage previously reported among proximally con-ceived pregnancies after danazol therapy for endometriosis.