Danazol has potential to cause PKC translocation, cell cycle dysregulation, and apoptosis in breast cancer cells

Suman Jyoti Deka, Ashalata Roy, Vibin Ramakrishnan, Debasis Manna, Vishal Trivedi
In: Chemical Biology & Drug Design · 2016 · vol. 89(6) , pp. 953–963 · doi:10.1111/cbdd.12921 · PMID:27933735 · W2559837447
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-07, 2026-07-25 ⓘ

Danazol induces apoptosis in breast cancer cells by causing DNA fragmentation, affecting mitochondrial membrane potential, and releasing cytochrome-C, potentially requiring treatment strategy optimization.

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Abstract

of 31 ± 2.63 and 65 ± 4.27 μg/ml, respectively. DNA fragmentation and flow cytometry experiments revealed that the cell death follows the apoptotic pathway. It affects mitochondrial membrane potentials and releases cytochrome-C from mitochondria to induce downstream apoptosis in breast cancer cells. Hence, the current study may help clinicians to re-design their treatment strategy to optimize therapeutic potentials of the molecule.

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chemicals 4
danazol danazol danazol danazol

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