Cell-Imaging Studies of Highly Substituted Oxazole Derivatives as Organelle Targeting Fluorophores (OTFPs)

The field of biomedical science had progressed enormously in the past decade. With the advent of newer diagnostic tools for imaging, detection and identification root cause of a disease has become remarkably accurate and specific. Small organic fluorophores in these connections are in great demand currently for cellular organelle sensing and detecting, due to their non-invasiveness, excellent accuracy and bio-sensitivity. Small molecule fluorescence probes offer most potent area for biological sensing with diagnostic imaging ability in the laboratory, these organelle targetable fluorescent probes (OTFPs) can be tuned through synthetic manipulations to produce desired, decent fluorescence properties. When a suitable organelle specific targetable group is installed within these highly fluorescent scaffolds, then these molecules may act as lysotracker, mitotracker and cytoplasm-stainer in mammalian cells with high efficiencies (high Pearson co-efficient factors). The present work demonstrated an environmentally benign (green) one-pot, C (sp 3 ) − H functionalization of highly substituted oxazole derivatives with excellent photophysical properties. These molecules were further modified by installing organelle specific targetable groups (sensors/detectors) which selectively localize in specific intra-cellular organelles.