Comparison of sperm activity indices in the experimental model of healthy male BALB/C mice and subacute bisphenol A (Bpa) poisoning

Comparison of sperm activity indices in the experimental model of healthy male BALB/C mice and subacute bisphenol A (Bpa) poisoning | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Comparison of sperm activity indices in the experimental model of healthy male BALB/C mice and subacute bisphenol A (Bpa) poisoning Homayoun Ganjavar, Majid Mohammadsadegh, Saber Almousavi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5617985/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Endocrine disrupting chemicals or xenoestrogens are natural or synthetic compounds that have the ability to disrupt the endocrine system by mimicking or blocking endogenous hormones. Therefore, the aim of the present study was to compare sperm activity indices in the experimental model of healthy male BALB/C mice and subacute bisphenol A (Bpa) poisoning. For this purpose, 30 mice were purchased and divided into 5 groups of 6 for testing. The rats in the first group were negative control , second group received propylene glycol as vehicle control and in the following groups received different doses of bisphenol A (from 50 mg/kg/daily to 600 mg/kg/daily) . Then, the sperms were sampled and the quality indicators of the sperms such as percentage of motility, viability, etc. were evaluated. Finally, using statistical methods, the results obtained in the present study were statistically analyzed. The average indices of concentration (p=0.001), motility and amount of progressive sperm (p=0.003), amount of motile sperm (p=0.001), live sperm (p=0.0001) and sperm with normal morphology (p=0.003) in the receiving groups Bisphenol A was significantly reduced. The study shows that , the chemical bisphenol A has a very destructive effect on sperm and effectively causes infertility. Bisphenol A Sperm infertility toxicity Full Text Additional Declarations No competing interests reported. Supplementary Files CASAResult.rar Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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