Skilled lipreaders read and listen to lips

ABSTRACT Only a few of us are skilled lipreaders while most struggle at the task. To illuminate the poorly understood neural substrate of this variability, we estimated the similarity of brain activity during lipreading, listening, and reading of the same 8-min narrative with subjects whose lipreading skill varied extensively. The similarity of brain activity was estimated by voxel-wise comparison of the BOLD signal time courses. Inter-subject correlation of the time courses revealed that lipreading and listening are supported by the same brain areas in temporal, parietal and frontal cortices, precuneus and cerebellum. However, lipreading activated only a small part of the neural network that is active during listening/reading the narrative, demonstrating that neural processing during lipreading vs. listening/reading differs substantially. Importantly, skilled lipreading was specifically associated with bilateral activity in the superior and middle temporal cortex, which also encode auditory speech. Our novel results both confirm previous results from few previous studies using isolated speech segments as stimuli but also extend in an important way understanding of neural mechanisms of lipreading.