The effect of a synthetic GnRH analogue on catamenial epilepsy: a study in ten patients

Summary Ten female patients suffering from catamenial epilepsy were treated with a synthetic analogue of the gonadotrophin releasing hormone (GnRH) in additon to antiepileptic drugs. Three of the patients became seizure free, in four patients seizure frequency decreased and in one patient seizures were of shorter duration. In only two of the patients was there no therapeutic effect. Adverse effects, including hot flushes, headache and increase in weight, were noticed in eight patients. These results support the hypothesis that treatment with a synthetic GnRH analogue might be helpful in patients with intractable catamenial epilepsies. Similar content being viewed by others References Almquist R (1955) The rhythm of epileptic attacks and its relationship to the menstrual cycle. Munksgaard, Kopenhagen Ansell B, Clarke E (1956) Epilepsy and menstruation, the role of water retention. 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