Mechanism of pain generation for endometriosis-associated pelvic pain

Purpose Endometriosis-associated pelvic pain appears due to persistent nociceptive stimulation, but the precise mechanisms remain poorly understood.

A search was conducted to screen and select articles from PubMed. Main results Neurotrophins (NTs), a family of neuronal growth factors, are overexpressed in endometriosis and encompass NGF, BDNF and NT-3 and NT-4/5. NT receptors, TrkA and p75NTR, and NT receptor-interacting proteins, MAGE and NDN, were also expressed. NTs and their receptors play a role in the development and maintenance of neural tissues in non-neuronal cell types such as endometriosis. Nerve fibers contain unmyelinated sensory C, myelinated sensory Adelta and adrenergic nerve fibers that innervate abnormal cell growths. An increased release of proinflammatory cytokines from endometriotic lesions is responsible for the excessive sensory innervation and development of chronic pelvic pain.

The preponderance of the inflammatory milieu and subsequent hyperinnervation might be involved in the pathophysiology of pain generation in women with endometriosis. Similar content being viewed by others

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Baillieres Clin Obstet Gynaecol 9:769–774 Acknowledgments The present review was supported by grant-in-aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan to the Department of Obstetrics and Gynecology, Nara Medical University (to H.K.). Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Kobayashi, H., Yamada, Y., Morioka, S. et al. Mechanism of pain generation for endometriosis-associated pelvic pain. Arch Gynecol Obstet 289, 13–21 (2014). https://doi.org/10.1007/s00404-013-3049-8 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-013-3049-8