Screening and Quantification of Antiquorum-Sensing Activity of Actinobacteria Isolates Against Gram-Positive and Gram-Negative Biofilm Associated Bacteria

Screening and Quantification of Antiquorum-Sensing Activity of Actinobacteria Isolates Against Gram-Positive and Gram-Negative Biofilm Associated Bacteria | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Research note Screening and Quantification of Antiquorum-Sensing Activity of Actinobacteria Isolates Against Gram-Positive and Gram-Negative Biofilm Associated Bacteria Marco Wijaya, Dea Delicia, Diana Elizabeth Waturangi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.24412/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objectives: The purpose of the study is to screen antiquorum sensing activity compound from actinobacteria using Chromobacterium violaceum as indicator and quantify the antibiofilm activity against several biofilm-forming pathogenic bacteria, such as Staphylococcus aureus ATCC 29213, Bacillus cereus ATCC 14579, Enterococcus faecalis ATCC 33186, Vibrio cholerae , Salmonella typhimurium , Pseudomonas aeruginosa ATCC 27853. Results: Crude extracts from marine actinobacteria isolated from Indonesia were promising for treating biofilm-related diseases. Out of 40 isolates 10 were found to have great quorum quenching activity against C. violaceum. Moreover, these isolates were able to inhibit biofim formation by Gram positive and Gram negative pathogenic bacteria. Quorum quenching agents in extracts of 1AC, 14PM, 16PM, 18PM, and CW17 isolates were predicted as proteins or enzymes. Bacteriology Actinobacteria Antibiofilm Chromobacterium violaceum Quorum sensing Quorum quenching Figures Figure 1 Introduction Bacteria can communicate with each other using unique chemical compounds called autoinducer. Communication activity of bacteria is known as quorum sensing. This mechanism is referring to the capacity of bacteria to monitor their cell density. Quorum sensing also affects the genes expression which influences microbial behaviors, such as regulating virulence factors and biofilm formation [ 1 ,2]. Biofilm formation is a process when flocked bacteria develop extracellular matrix that facilitate attachment. It gives rise to serious problems for public health because biofilm-associated organisms are more resistant to chemical agents and physical treatments. In this case, the probability of successful infections will increase [ 2 ]. Every activity to inhibit bacterial quorum sensing is known as quorum quenching. It has been proposed as novel therapeutics for treating biofilm-based diseases. The biofilm-based diseases are usually treated by antibiotics. However, the use of antibiotics is not an effective solution and might lead to antibiotic resistance. Actinobacteria are fungi-like Gram-positive bacteria, well known as a supreme producer of secondary metabolite compounds [ 3 ], but research around antiquorum sensing and antibiofilm from these bacteria yet have not been much explored. The objectives of this research are to screen antiquorum sensing activity compound from actinobacteria using C. violaceum as indicator and quantify the antibiofilm activity against several biofilm-forming pathogenic bacteria. Methods Bacterial Cultivation Fourty actinobacteria isolates used in this research were obtained from the previous study [4,5] that isolated from aquatic environments in Indonesia . Actinobacteria were cultured onto Yeast Malt Extract Agar (YMEA) incubated at 28°C for 7 days. Indicator strains of quorum sensing activity were C. violaceum wild type and C. violaceum CV026 cultivated onto Luria Agar (LA) and incubated at 28°C for 24 h. While six pathogenic bacteria which were B. cereus ATCC 14579 , S. aureus ATCC 29213 , and E. faecalis ATCC 33186, P . aeruginosa ATCC 27853, S . typhimurium , V . cholerae cultivated onto LA and incubated at 37°C for 24 h. Primary Screening of Antiquorum Sensing Activity The assay was conducted using the overlay agar method [6] with modification. Actinobacteria isolates were inoculated into YMEA then incubated at 28°C for 3 days. C. vi olaceum were grown separately in Luria Broth (LB) and incubated at 28°C for 24 h. The indicator strain diluted within semisolid agar (0.75% LA) until OD 600 =0.132 and poured onto YMEA plates. These plates were incubated at 28°C for 24 h. Positive result indicating antiquorum sensing can be seen through the absence of violacein pigment production around actinobacteria isolates. Preparation of Crude Extract Each isolate was inoculated into Tryptic Soy Broth (TSB) supplemented with glucose (1% w/v). The culture was incubated at 28°C for 7 days at 125 rpm then centrifuged at 7,800xg for 15 minutes. The supernatant was mixed with ethyl acetate in a 1:1 ratio and shaken at 150 rpm overnight. The solvent phase was evaporated using rotary evaporator then dried using vacuum oven and resuspended in Dimethyl Sulphoxide (DMSO). Crude extracts were stored at -20°C for a month [7,8,9] Antimicrobial Assay Assay is conducted using agar well diffusion method [10]. Tested bacteria (OD 600 =0.132) were streaked onto Brain Heart Infusion Agar (BHIA). The crude extract (50 µL) of actinobacteria with various concentration (10 and 20 mg/mL) was added. DMSO (1% v/v) was used as the negative control, while streptomycin (10 mg/mL) was used as the positive control. The plates were incubated at 37°C for 24 h. Detection of Antiquorum Sensing Activity This assay was conducted based on [11] with modification. C. violaceum (OD 600 =0.132) used as indicator strain streaked onto BHIA. The crude extract (50µL) of actinobacteria with various concentration (10 and 20 mg/mL) was added. DMSO (1% v/v) was used as a control. The plates were incubated at 28°C for 24 h. Antiquorum sensing activity was determined qualitatively through the inhibition of violacein production around the wells [12] Quantification of Antibiofilm Activity Quantification of antibiofilm activity was conducted based [8] with modification. The antibiofilm activity was divided into inhibition and destruction activity. For inhibition activity assay, each pathogen was inoculated into Brain Heart Infusion Broth (BHIB) supplemented with glucose (2% w/v) and incubated at 37°C, 150 rpm for 24 h. Then 100 µL of bacterial culture (OD 600 =0.132) and 100 µL of crude extract was transferred to the 96-wells microplate to quantify the biofilm inhibition activity. For destruction activity assay, another 96-wells plate was filled with diluted culture and re-incubated at 37°C for 24 h until mature biofilm attached to the well. Crude extract (100 µL) was added to each well to quantify the biofilm destruction activity. Overnight culture of pathogens without any treatment was used as a positive control, while sterile BHIB was used as the negative control. After incubation, planktonic cells and media were discarded. Adherent cells were rinsed twice with sterile water and stained using crystal violet (0.4% w/v) for 30 minutes. 96-wells were rinsed twice and air-dried for 5 minutes. About 200 µL of ethanol was added and resuspended. Absorbance was determined at 595 nm with a microplate reader (TECAN M200 PRO). This assay was performed in triplicates. Percentage of inhibition or destruction activity was calculated by the equation below: Validation of Quorum sensing inhibition Validation assay was conducted based on [11]. The culture of C. violaceum CV026 (OD 600 =0.132) was mixed with 100 µL of the crude extract and 1 µmol/mL of Hexanoyl-L-Homoserine-Lactone (HHL). The culture was incubated at 28°C for 24 h. Positive control contained culture and 1 µmol/mL of HHL without crude extract. The tested tubes were centrifuged at 1000rpm for 15 minutes. About 1 mL of DMSO (1% v/v) mixed and centrifuged. The absorbance of the supernatant was measured at 540 nm. Furthermore, the determination of protein compounds in the crude extract was performed. Each crude extract was treated with proteinase-K (100 µg/mL) for 2 h incubation in 37°C and heat loss method with 95°C for 1 h. The treated crude extract was used to do the validation assay. Total violacein produced by C. violaceum CV026 was compared [13] Examination of Biofilm formation by Scanning Electron Microscope (SEM) The effect of crude extract was investigated using SEM at Dexa Laboratory of Biomolecular and Science (DLBS), Cikarang, Indonesia. B. cereus and S. typhimurium were grown in BHIB supplemented with glucose (2% w/v) and incubated at 37ºC for 24 h. Bacterial culture (100 µL) were spotted to sterile cover glass kept in sterile petri dish and incubated at 37ºC for 24 h to form a mature biofilm. After the incubation period, 100 µL of crude extract with the highest destruction activity was added into the formed biofilm and incubated at 37°C for 24 h. Mature biofilm without crude extract was used as control [14]. Statistical Analysis Statistical analysis was conducted by using IBM SPSS Statistics 23. The results were analyzed using the analysis of variances (ANOVA) and the Tukey test for significant difference were determined at P <0.05 and standard error was determined using Microsoft Excel 2016. Results Bacterial Characteristic Actinobacteria isolates have specific characteristics, such as calcareous-like, opaque big colonies, embedded or strongly attached to the agar medium, and produce earthy odor compounds called geosmin. Screening for Antiquorum Sensing Activity Inhibition of violacein pigment was determined as a positive result. According to this assay, The results showed that 10 out of 40 actinobacteria isolates had antiquorum sensing activity without inhibiting C.violaceum growth. Antibacterial Activity Assay There were found 3 out of the 10 actinobacteria crude extracts showed antibacterial activity against V. cholerae and non-antibacterial activity against other pathogens, while positive control inhibited the growth of tested pathogens. Detection of Antiquorum Sensing Activity All 10 isolates also performed great quorum quenching activity against C. violaceum shown with absence of violacein pigment observed around the wells . Presence of quorum quenching activity would inhibit violacein production. Validation Test Antiquorum Sensing Activity and Protein Characterization The results shown in Table 1 indicate that all 10 isolates showed quorum quenching activity compared with the control. Quorum quenching agents in extracts 1AC, 14PM, 16PM, 18PM, and CW17 showed a significant increase in absorbance value after Proteinase-K treatment, while extracts from 11AC, 15PM, 20PM, CW01, CW17, and TB12 showed lower absorbance value (Table 1). Biofilm Inhibition and Destruction Assay From this assay, all crude extracts were capable of inhibiting and destructing biofilm formation (Table 2). Antibiofilm activity performed were broad spectrum. Antibiofilm against Gram positive bacteria was correlated with the concentration while results against Gram negative bacteria was varied. Microscopic Observation using Scanning Electron Microscope Figure 1a and 1b showed the topographical biofilm formation of B. cereus before and after treated with crude extract of 20PM isolate. While Figure 1c and 1d showed biofilm of S. typhimurium. Drastic morphological change observed after treatment of actinobacteria crude extract. Discussion Actinobacteria live in an environment that leads them to do some kind of competitions for combating other microorganisms in various situations. Actinobacteria produce several metabolites such as antimicrobial, antiquorum sensing, antibiofilm, and several other supporting compounds. From the first screening of antiquorum sensing activity, only 10 out of 40 actinobacteria isolates showed antiquorum sensing activity. Screening of antimicrobial activity is needed because it might lead to false-positive result in further assays. There was no clear zone observed, except in V. cholerae . Isolates showing quorum quenching activity are validated. All 10 isolates showed great activity in inhibiting C. violaceum quorum sensing activity as seen from lower pigment production. Quorum quenching agents in extracts of 1AC, 14PM, 16PM, 18PM, and CW17 isolates were predicted as proteins or enzymes because they showed a significant increase in absorbance value after proteinase-K treatment. The treatment might affect protein-based antiquorum sensing compounds produced by actinobacteria, such as AHL lactonase, acylase, decarboxylase, oxidoreductase, and deaminase [ 15 ]. Those enzymes were degraded by the treatment. In the absence of antiquorum sensing compounds, HHL (C6) signal will diffuse into bacterial cells and binds with LuxR receptor formed a protein-ligand complex. This complex will activate violacein production. The more violacein produced, the higher absorbance will be detected [ 16 ]. Crude extract from isolate 15PM, 20PM, CW01, and TB12 treated with proteinase-K showed better activity. It might indicate that proteinase-K degrades the competitive proteins which share similar receptor or degrades proteins that can inhibit the quorum quenching activity [ 17 ]. Other probabilities, the antiquorum sensing compounds were produced in inactive form hence reaction with Proteinase-K will activate the antiquorum sensing compound [ 18 ]. Antibiofilm activity usually correlates with concentration, but few isolates did not show any significant difference. It might be caused by several factors. For instance, lower concentration of crude extracts might degrade all the ECM. Crude extracts might also contain some inhibitors or analog components that match competitively to the receptor. According to [ 19 ] undesirable component might affect the effectiveness of the crude extracts. Some components in the crude extracts might work antagonistically or synergistically that can decrease or increase the activity [ 18 , 20 ]. Topographical observation using SEM showed the presence of biofilm. S. typhimurium biofilm before treated with crude extracts showed a rough surface, which means there is a presence of ECM. After the treatment, Fig. 1 d showed the crude extracts contained matrix-degrading enzymes due to the depletion and erosion across the surfaces. On the other head, B. cereus showed thick biofilm formation. Treatment with crude extract of 20PM isolate is competent to degrade ECM and Biofilm formation [ 2 1]. Conclusion There were 10 isolates performed great quorum quenching and antibiofilm both destruction and inhibition activity against P . aeruginosa ATCC 27853, S . typhimurium , V . cholerae, B. cereus ATCC 14579 , S. aureus ATCC 29213 , and E. faecalis ATCC 33186. Quorum quenching compound in extracts 1AC, 14PM, 16PM, 18PM, and CW17 were predicted as proteins. Further research is required to purify the bioactive compounds, characterize the bioactive compounds in each crude extract, and identify the potential isolates. Limitation This research did not comprehend the specific compound in the crude extract that competent to perform antibiofilm and antiquorum sensing activity. species of actinobacteria have not identified, characterization of crude extract limited to protein compounds, and the specific mechanism of the quorum quenching activity of each isolate did not determine. Abbreviations HHL: Hexanoyl-L-Homoserine-Lactone AI: Autoinducer AHL: Acyl Homoserine Lactone SEM: Scanning Electron Microscope ECM: Extracellular Matrix Declarations Ethics approval and consent to participate. Not applicable Consent for publication. Not applicable Availability of data and materials. The data of this study is available with the corresponding author up on request. Competing interests. The authors declare that they have no competing interests Funding. This research had funded by Ministry of Research, Technology and Higher Education of the Republic of Indonesia 2019 and Faculty of Biotecnology, Atma Jaya Catholic University of Indonesia 2019. The funder has no contribution in design, collection, writting, and interpreting data in this research. Authors’ Contribution. MW and DD: Proposal Writting, Conducted research, Data Analysis, and manuscript under advisory of DEW. DEW: Provide the materials, methods and proposal design, and bacteria used in this research. being a final investigator in this research. Acknowledgement. The authors thankfully acknowledge the microscopy facility that provided by the PT Dexa Laboratories of Biomolecular Sciences (DLBS) Author details. 1 Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia. Jenderal Sudirman 51 Street, South Jakarta, DKI Jakarta, 12930, Indonesia. References 1. Das S, Dash HR. Microbial-biotechnology: a laboratory manual for bacterial systems. New Delhi: Springer, 2015. p203 Rabin N, Zheng Y, Opoku TC, Du Y, Bonsu E, Sintim HO. Biofilm formation mechanisms and targets for developing antibiofilm agents. Future Med. Chem. 2015; doi: 10.4155/FMC.15.6. Li Q, Chen X, Jiang Y, Jiang C. 2016. Actinobacteria - Basics and Biotechnological Applications. doi:10.5772/61461 Screening of actinomycetes from marine sediments to inhibit Vibrio cholerae biofilm formation. Biotechnology, Honours [Thesis]. Jakarta (ID): Atma Jaya Catholic University of Indonesia; 2011. Vidyawan V. Screening of actinomycetes from various environment sediments to inhibit biofilm formation of Vibrio cholerae . Biotechnology, Honours [Thesis]. Jakarta (ID): Atma Jaya Catholic University of Indonesia; 2013. Abudoleh SM, Mahasneh AM. Anti-quorum sensing activity of substance isolated from wild berry associated bacteria. Avicenna J Medical Biotechnol. 2017;9(1):1-8. Rajivgandhi G, Senthil R, Ramachandran G, Manoharan N. Antibiofilm activity of marine endophytic actinomycetes compound isolated from mangrove plant Rhizophora mucronata , Muthupet Mangrove Region, Tamil Nadu, India. J Terr Mar Res. 2018; 2(4):1-7. Waturangi DE, Rahayu BS, Lalu KY, Michael, Mulyono N. Characterization of bioactive compound from actinomycetes from antibiofilm activity against Gram-negative and Gram-positive bacteria. Malays J Microbiol. 2016; doi :10.21161/mjm.80915 . Nithya C, Aravindraja C and Pandian SK. 2010. Bacillus pumilus of Palk Bay origin inhibits quorum-sensing-mediated virulence factors in Gram-negative bacteria. Res. Microbiol. 2010; 161 293–304. Nathan P, Law EJ, Murphy DF. A laboratory method for the selection of topical antimicrobial agents to treat infected burn wounds. Burn. 1978; 4.177-17. Rajivgandhi G, Vijayan R, Maruthupandy M, Vaseeharan B, Manoharan N. Antibiofilm effect of Nocardiopsis GRG 1 (KT235640) compound against biofilm-forming Gram-negative bacteria on UTIs. Microbial Pathogenis. 2018; doi: 10.1016/j.micpath.2018.03.011 Khan MSA, Zahin M, Hasan S, Husain FM, Ahmad I. Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil. Lett Appl Microbiol. 2009; doi:10.1111/j.1472-765x.2009.02666.x. Thenmozhi, R. P., Nithya, J. R. & Pandian, S. K. Antibiofilm activity of coral-associated bacteria against different clinical M serotypes of Streptococcus pyogenes . FEMS Immunol Med Microbiol. 57, 284-294 (2009). Luo J, Dong B, Wang K, Cai S, Liu T, Cheng X, Lei D, Chen Y, Kong J, Chen Y. Baicalin 263 inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances 264 Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. PLoS 265 ONE. 2017;12(4): e0176883. Chen F, Gao Y, Chen X, Yu Z, Li X. Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection. Intl. J. Mol. Sci. 2013; doi:10.3990/IJMS140917477 Stauff DL, Bassler BL. Quorum Sensing in Chromobacterium violaceum : DNA Recognition and Gene Regulation by the CviR Receptor. J Bacteriol. 2011; doi:10.1128/jb.05125-11. Omran R, Kadhem MF. Production, purification, characterization of bioactive metabolites produced from rare Actinobacteria psudonocardia Asian J Pharm Clin res. 2016; 9(3):264-272. LaSarre B, Federle MJ. Exploiting quorum sensing to confuse bacterial pathogens. 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Tables Table 1 Absorbances of total violacein produced by C. violaceum CV026 Isolate CV026 + Extract CV026 + Extract + proteinase-K + 95 o C 1AC 0.9770±0.0092 1.0310±0.0035 11AC 1.0460±0.0029 1.0260±0.0069 14PM 0.8050±0.046 1.0300±0.0029 15PM 0.8565±0.0020 0.7505±0.0234 16PM 0.8625±0.0026 1.1090±0.0012 18PM 0.9190±0.0058 1.1320±0.0035 20PM 1.1760±0.0003 0.8650±0.0115 CW01 1.1230±0.0012 0.8865±0.0009 CW17 0.6945±0.0430 0.9070±0.0046 TB12 1.1690±0.0018 1.0945±0.0141 Control 1.18515±0.0031 1.1845±0.0032 CV026 = C. violaceum CV026 Table 2 Antibiofilm activity of actinobacteria crude extracts against pathogenic biofilm associated bacteria Pathogen Antibiofilm Activity Crude Extract (%) % Activity 1AC 11AC 14PM 15PM 16PM 18PM 20PM CW01 CW17 TB12 SA 5 65 87* 78 43 64 46 55 76 74 44 10 90* 90* 79 66 75 74 76 77 75 62 BC 5 89* 85 76 78 84 57 86 84 85 81 10 90* 87 76 83 87 69 88 87 85 84 EF 5 49 70 12 36 43 15 27 76 83* 33 Inhibition 10 82 71 34 71 77 40 50 83 84* 81 VC 5 93 89 90 X 93 X X 9 92 94* 10 76 79 84* X 82 X X 83 70 58 ST 5 76 83 84 80 81 81 85* 80 81 81 10 56 63 50 54 27 76* 59 63 66 25 PA 5 29 70 49 38 50 39 37 47 54* 42 10 83 82 86 91 85 81 89 93* 87 37 SA 5 62* 32 41 38 40 38 42 45 50 37 10 77* 49 54 74 59 65 62 60 59 61 BC 5 61 67 64 67 65 67 75* 72 73 67 10 84 80 78 68 84 75 85* 83 74 79 EF 5 43 44 50 47 47 45 46 50 52* 43 Destruction 10 58 63 55 70 72* 70 65 52 63 45 VC 5 - 52 - X 71 X X 73* 71 70 10 11 48 62* X 13 X X 43 52 43 ST 5 57 43 54 34 29 58 51 66 73* 64 10 56 20 72 54 47 82* 64 79 78 42 PA 5 11 53 29 54 63* 17 59 38 26 58 10 43 45 41 57 42 50 55* 50 55* 50 Staphylococcus aureus ATCC 29213; Bacillus cereus ATCC 14579; Enterococcus faecalis ATCC 33186, Vibrio cholerae , Salmonella typhimurium , Pseudomonas aeruginosa ATCC 27853. *Highest activity, X Have antimicrobial activity, - No activity Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-14971","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research note","associatedPublications":[],"authors":[{"id":366637,"identity":"b9e1195d-3c52-49f5-b45d-8390d3e7e397","order_by":1,"name":"Marco Wijaya","email":"","orcid":"","institution":"Universitas Katolik Indonesia Atma Jaya","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Marco","middleName":"","lastName":"Wijaya","suffix":""},{"id":366638,"identity":"d9829c1a-074a-4479-aef5-b3f1b8591218","order_by":2,"name":"Dea Delicia","email":"","orcid":"","institution":"Universitas Katolik Indonesia Atma Jaya","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dea","middleName":"","lastName":"Delicia","suffix":""},{"id":366639,"identity":"a08bb18b-83d0-49e9-b173-a36da95ba1ea","order_by":3,"name":"Diana Elizabeth Waturangi","email":"data:image/png;base64,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","orcid":"","institution":"Universitas Katolik Indonesia Atma Jaya","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Diana","middleName":"Elizabeth","lastName":"Waturangi","suffix":""}],"badges":[],"createdAt":"2020-02-22 11:26:23","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.24412/v1","doiUrl":"https://doi.org/10.21203/rs.2.24412/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":544568,"identity":"b0a0ddbb-8a7c-4503-8ef0-64b5f672f01f","added_by":"auto","created_at":"2020-02-25 16:52:36","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":2099258,"visible":true,"origin":"","legend":"Biofilm of B. cereus ATCC 14579. (a) without treatment (b) with addition crude extract of 20PM isolate. Biofilm of S. typhimurium. (c) without treatment (d) with addition crude extract of CW01 isolate","description":"","filename":"SEMMERGED.jpg","url":"https://assets-eu.researchsquare.com/files/99d4f7b1-70f5-4999-9a95-4511347d9b56/v1/SEM MERGED.jpg"},{"id":13491252,"identity":"754ee251-605c-4147-afc0-71d2d9570412","added_by":"auto","created_at":"2021-09-16 22:26:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":714447,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-14971/v1/9335ec92-2c4c-4c82-abe3-8723317947f1.pdf"}],"financialInterests":"","formattedTitle":"Screening and Quantification of Antiquorum-Sensing Activity of Actinobacteria Isolates Against Gram-Positive and Gram-Negative Biofilm Associated Bacteria","fulltext":[{"header":"Introduction","content":" \u003cp\u003eBacteria can communicate with each other using unique chemical compounds called autoinducer. Communication activity of bacteria is known as quorum sensing. This mechanism is referring to the capacity of bacteria to monitor their cell density. Quorum sensing also affects the genes expression which influences microbial behaviors, such as regulating virulence factors and biofilm formation [\u003csup\u003e1\u003c/sup\u003e,2].\u003c/p\u003e \u003cp\u003eBiofilm formation is a process when flocked bacteria develop extracellular matrix that facilitate attachment. It gives rise to serious problems for public health because biofilm-associated organisms are more resistant to chemical agents and physical treatments. In this case, the probability of successful infections will increase [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Every activity to inhibit bacterial quorum sensing is known as quorum quenching. It has been proposed as novel therapeutics for treating biofilm-based diseases.\u003c/p\u003e \u003cp\u003eThe biofilm-based diseases are usually treated by antibiotics. However, the use of antibiotics is not an effective solution and might lead to antibiotic resistance. Actinobacteria are fungi-like Gram-positive bacteria, well known as a supreme producer of secondary metabolite compounds [\u003csup\u003e3\u003c/sup\u003e], but research around antiquorum sensing and antibiofilm from these bacteria yet have not been much explored. The objectives of this research are to screen antiquorum sensing activity compound from actinobacteria using \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eC. violaceum\u003c/span\u003e as indicator and quantify the antibiofilm activity against several biofilm-forming pathogenic bacteria.\u003c/p\u003e "},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eBacterial Cultivation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFourty actinobacteria isolates used in this research were obtained from the previous study [4,5] that isolated from aquatic environments in Indonesia\u003cem\u003e. \u003c/em\u003eActinobacteria were cultured onto Yeast Malt Extract Agar (YMEA) incubated at 28\u0026deg;C for 7 days. Indicator strains of quorum sensing activity were\u003cem\u003e C. violaceum \u003c/em\u003ewild type and \u003cem\u003eC. violaceum\u003c/em\u003e CV026 cultivated onto Luria Agar (LA) and incubated at 28\u0026deg;C for 24 h. While six pathogenic bacteria which were \u003cem\u003eB. cereus \u003c/em\u003eATCC 14579\u003cem\u003e, S. aureus \u003c/em\u003eATCC 29213\u003cem\u003e, and E. faecalis \u003c/em\u003eATCC 33186, \u003cem\u003eP\u003c/em\u003e.\u003cem\u003e aeruginosa\u003c/em\u003e ATCC 27853, \u003cem\u003eS\u003c/em\u003e.\u003cem\u003e typhimurium\u003c/em\u003e, \u003cem\u003eV\u003c/em\u003e.\u003cem\u003e cholerae\u003c/em\u003e cultivated onto LA and incubated at 37\u0026deg;C for 24 h.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrimary Screening of Antiquorum Sensing Activity\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe assay was conducted using the overlay agar method [6] with modification. Actinobacteria isolates were inoculated into YMEA then incubated at 28\u0026deg;C for 3 days. C. vi\u003cem\u003eolaceum\u003c/em\u003e were grown separately in Luria Broth (LB) and incubated at 28\u0026deg;C for 24 h. The indicator strain diluted within semisolid agar (0.75% LA) until OD\u003csub\u003e600\u003c/sub\u003e=0.132 and poured onto YMEA plates. These plates were incubated at 28\u0026deg;C for 24 h. Positive result indicating antiquorum sensing can be seen through the absence of violacein pigment production around actinobacteria isolates.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePreparation of Crude Extract\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEach isolate was inoculated into Tryptic Soy Broth (TSB) supplemented with glucose (1% w/v). The culture was incubated at 28\u0026deg;C for 7 days at 125 rpm then centrifuged at 7,800xg for 15 minutes. The supernatant was mixed with ethyl acetate in a 1:1 ratio and shaken at 150 rpm overnight. The solvent phase was evaporated using rotary evaporator then dried using vacuum oven and resuspended in Dimethyl Sulphoxide (DMSO). Crude extracts were stored at -20\u0026deg;C for a month [7,8,9]\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntimicrobial Assay\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAssay is conducted using agar well diffusion method [10]. Tested bacteria (OD\u003csub\u003e600\u003c/sub\u003e=0.132) were streaked onto Brain Heart Infusion Agar (BHIA). The crude extract (50 \u0026micro;L) of actinobacteria\u0026nbsp; with various concentration (10 and 20 mg/mL) was added. DMSO (1% v/v) was used as the negative control, while streptomycin (10 mg/mL) was used as the positive control. The plates were incubated at 37\u0026deg;C for 24 h.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetection of Antiquorum Sensing Activity\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis assay was conducted based on [11] with modification. \u003cem\u003eC. violaceum \u003c/em\u003e(OD\u003csub\u003e600\u003c/sub\u003e=0.132) used as indicator strain streaked onto BHIA. The crude extract (50\u0026micro;L) of actinobacteria with various concentration (10 and 20 mg/mL) was added. DMSO (1% v/v) was used as a control. The plates were incubated at 28\u0026deg;C for 24 h. Antiquorum sensing activity was determined qualitatively through the inhibition of violacein production around the wells [12]\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuantification of Antibiofilm Activity\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eQuantification of antibiofilm activity was conducted based [8] with modification. The antibiofilm activity was divided into inhibition and destruction activity. For inhibition activity assay, each pathogen was inoculated into Brain Heart Infusion Broth (BHIB) supplemented with glucose (2% w/v) and incubated at 37\u0026deg;C, 150 rpm for 24 h. Then 100 \u0026micro;L of bacterial culture (OD\u003csub\u003e600\u003c/sub\u003e=0.132) and 100 \u0026micro;L of crude extract was transferred to the 96-wells microplate to quantify the biofilm inhibition activity. For destruction activity assay, another 96-wells plate was filled with diluted culture and re-incubated at 37\u0026deg;C for 24 h until mature biofilm attached to the well. Crude extract (100 \u0026micro;L) was added to each well to quantify the biofilm destruction activity. Overnight culture of pathogens without any treatment was used as a positive control, while sterile BHIB was used as the negative control.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAfter incubation, planktonic cells and media were discarded. Adherent cells were rinsed twice with sterile water and stained using crystal violet (0.4% w/v) for 30 minutes. 96-wells were rinsed twice and air-dried for 5 minutes. About 200 \u0026micro;L of ethanol was added and resuspended. Absorbance was determined at 595 nm with a microplate reader (TECAN M200 PRO). This assay was performed in triplicates. Percentage of inhibition or destruction activity was calculated by the equation below:\u003c/p\u003e\n\u003cp\u003e\u003cimg style=\"width: 232px;\" 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\" alt=\"\" /\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eValidation of Quorum sensing inhibition\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eValidation assay was conducted based on [11]. The culture of \u003cem\u003eC. violaceum \u003c/em\u003eCV026 (OD\u003csub\u003e600\u003c/sub\u003e=0.132) was mixed with 100 \u0026micro;L of the crude extract and 1 \u0026micro;mol/mL of Hexanoyl-L-Homoserine-Lactone (HHL). The culture was incubated at 28\u0026deg;C for 24 h. Positive control contained culture and 1 \u0026micro;mol/mL of HHL without crude extract. The tested tubes were centrifuged at 1000rpm for 15 minutes. About 1 mL of DMSO (1% v/v) mixed and centrifuged. The absorbance of the supernatant was measured at 540 nm. Furthermore, the determination of protein compounds in the crude extract was performed. Each crude extract was treated with proteinase-K (100 \u0026micro;g/mL) for 2 h incubation in 37\u0026deg;C and heat loss method with 95\u0026deg;C for 1 h. The treated crude extract was used to do the validation assay. Total violacein produced by \u003cem\u003eC. violaceum\u003c/em\u003e CV026 was compared [13]\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExamination of Biofilm formation by Scanning Electron Microscope (SEM)\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe effect of crude extract was investigated using SEM at Dexa Laboratory of Biomolecular and Science (DLBS), Cikarang, Indonesia. \u003cem\u003eB. cereus\u003c/em\u003e and \u003cem\u003eS. typhimurium \u003c/em\u003ewere grown in BHIB supplemented with glucose (2% w/v) and incubated at 37\u0026ordm;C for 24 h. Bacterial culture (100 \u0026micro;L)\u0026nbsp; were spotted to sterile cover glass kept in sterile petri dish and incubated at 37\u0026ordm;C for 24 h to form a mature biofilm. After the incubation period, 100 \u0026micro;L of crude extract with the highest destruction activity was added into the formed biofilm and incubated at 37\u0026deg;C for 24 h. Mature biofilm without crude extract was used as control [14].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStatistical analysis was conducted by using IBM SPSS Statistics 23. The results were analyzed using the analysis of variances (ANOVA) and the Tukey test for significant difference were determined at P \u0026lt;0.05 and standard error was determined using Microsoft Excel 2016.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eBacterial Characteristic\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eActinobacteria isolates have specific characteristics, such as calcareous-like, opaque big colonies, embedded or strongly attached to the agar medium, and produce earthy odor compounds called geosmin.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eScreening for Antiquorum Sensing Activity\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInhibition of violacein pigment was determined as a positive result. According to this assay, The results showed that 10 out of 40 actinobacteria isolates had antiquorum sensing activity without inhibiting \u003cem\u003eC.violaceum\u003c/em\u003e growth.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntibacterial Activity Assay\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere were found 3 out of the 10 actinobacteria crude extracts showed antibacterial activity against \u003cem\u003eV. cholerae\u003c/em\u003e and non-antibacterial activity against other pathogens, while positive control inhibited the growth of tested pathogens.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetection of Antiquorum Sensing Activity\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll 10 isolates also performed great quorum quenching activity against \u003cem\u003eC. violaceum \u003c/em\u003eshown with absence of violacein pigment observed around the wells\u003cem\u003e. \u003c/em\u003ePresence of quorum quenching activity would inhibit violacein production.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eValidation Test Antiquorum Sensing Activity and Protein Characterization\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe results shown in Table 1 indicate that all 10 isolates showed quorum quenching activity compared with the control. Quorum quenching agents in extracts 1AC, 14PM, 16PM, 18PM, and CW17 showed a significant increase in absorbance value after Proteinase-K treatment, while extracts from 11AC, 15PM, 20PM, CW01, CW17, and TB12 showed lower absorbance value (Table 1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiofilm Inhibition and Destruction Assay\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFrom this assay, all crude extracts were capable of inhibiting and destructing biofilm formation (Table 2). Antibiofilm activity performed were broad spectrum. Antibiofilm against Gram positive bacteria was correlated with the concentration while results against Gram negative bacteria was varied.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicroscopic Observation using Scanning Electron Microscope\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFigure 1a and 1b showed the topographical biofilm formation of \u003cem\u003eB. cereus\u003c/em\u003e before and after treated with crude extract of 20PM isolate. While Figure 1c and 1d showed biofilm of \u003cem\u003eS. typhimurium. \u003c/em\u003eDrastic morphological change observed after treatment of actinobacteria crude extract.\u003c/p\u003e"},{"header":"Discussion","content":" \u003cp\u003eActinobacteria live in an environment that leads them to do some kind of competitions for combating other microorganisms in various situations. Actinobacteria produce several metabolites such as antimicrobial, antiquorum sensing, antibiofilm, and several other supporting compounds.\u003c/p\u003e \u003cp\u003eFrom the first screening of antiquorum sensing activity, only 10 out of 40 actinobacteria isolates showed antiquorum sensing activity. Screening of antimicrobial activity is needed because it might lead to false-positive result in further assays. There was no clear zone observed, except in \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eV. cholerae\u003c/span\u003e. Isolates showing quorum quenching activity are validated. All 10 isolates showed great activity in inhibiting \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eC. violaceum\u003c/span\u003e quorum sensing activity as seen from lower pigment production.\u003c/p\u003e \u003cp\u003eQuorum quenching agents in extracts of 1AC, 14PM, 16PM, 18PM, and CW17 isolates were predicted as proteins or enzymes because they showed a significant increase in absorbance value after proteinase-K treatment. The treatment might affect protein-based antiquorum sensing compounds produced by actinobacteria, such as AHL lactonase, acylase, decarboxylase, oxidoreductase, and deaminase [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. Those enzymes were degraded by the treatment. In the absence of antiquorum sensing compounds, HHL (C6) signal will diffuse into bacterial cells and binds with LuxR receptor formed a protein-ligand complex. This complex will activate violacein production. The more violacein produced, the higher absorbance will be detected [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eCrude extract from isolate 15PM, 20PM, CW01, and TB12 treated with proteinase-K showed better activity. It might indicate that proteinase-K degrades the competitive proteins which share similar receptor or degrades proteins that can inhibit the quorum quenching activity [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. Other probabilities, the antiquorum sensing compounds were produced in inactive form hence reaction with Proteinase-K will activate the antiquorum sensing compound [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eAntibiofilm activity usually correlates with concentration, but few isolates did not show any significant difference. It might be caused by several factors. For instance, lower concentration of crude extracts might degrade all the ECM. Crude extracts might also contain some inhibitors or analog components that match competitively to the receptor. According to [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e] undesirable component might affect the effectiveness of the crude extracts. Some components in the crude extracts might work antagonistically or synergistically that can decrease or increase the activity [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eTopographical observation using SEM showed the presence of biofilm. \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eS. typhimurium\u003c/span\u003e biofilm before treated with crude extracts showed a rough surface, which means there is a presence of ECM. After the treatment, Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003ed showed the crude extracts contained matrix-degrading enzymes due to the depletion and erosion across the surfaces. On the other head, \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eB. cereus\u003c/span\u003eshowed thick biofilm formation. Treatment with crude extract of 20PM isolate is competent to degrade ECM and Biofilm formation [\u003csup\u003e2\u003c/sup\u003e1].\u003c/p\u003e "},{"header":"Conclusion","content":"\u003cp\u003eThere were 10 isolates performed great quorum quenching and antibiofilm both destruction and inhibition activity against \u003cem\u003eP\u003c/em\u003e.\u003cem\u003e aeruginosa\u003c/em\u003e ATCC 27853, \u003cem\u003eS\u003c/em\u003e.\u003cem\u003e typhimurium\u003c/em\u003e, \u003cem\u003eV\u003c/em\u003e.\u003cem\u003e cholerae, B. cereus \u003c/em\u003eATCC 14579\u003cem\u003e, S. aureus \u003c/em\u003eATCC 29213\u003cem\u003e, and E. faecalis \u003c/em\u003eATCC 33186. Quorum quenching compound in extracts 1AC, 14PM, 16PM, 18PM, and CW17 were predicted as proteins. Further research is required to purify the bioactive compounds, characterize the bioactive compounds in each crude extract, and identify the potential isolates.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLimitation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis research did not comprehend the specific compound in the crude extract \u0026nbsp;that competent to perform antibiofilm and antiquorum sensing activity. species of actinobacteria have not identified, characterization of crude extract limited to protein compounds, and the specific mechanism of the quorum quenching activity of each isolate did not determine.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eHHL: Hexanoyl-L-Homoserine-Lactone\u003c/p\u003e\n\u003cp\u003eAI: Autoinducer\u003c/p\u003e\n\u003cp\u003eAHL: Acyl Homoserine Lactone\u003c/p\u003e\n\u003cp\u003eSEM: Scanning Electron Microscope\u003c/p\u003e\n\u003cp\u003eECM: Extracellular Matrix\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate.\u003c/strong\u003e Not applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication.\u003c/strong\u003e Not applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials.\u003c/strong\u003e The data of this study is available with the corresponding author up on request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests.\u003c/strong\u003e The authors declare that they have no competing interests\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding.\u003c/strong\u003e This research had funded by Ministry of Research, Technology and Higher Education of the Republic of Indonesia 2019 and Faculty of Biotecnology, Atma Jaya Catholic University of Indonesia 2019. The funder has no contribution in design, collection, writting, and interpreting data in this research.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; Contribution.\u003c/strong\u003e MW and DD: Proposal Writting, Conducted research, Data Analysis, and manuscript under advisory of DEW. DEW: Provide the materials, methods and proposal design, and bacteria used in this research. being a final investigator in this research.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgement.\u003c/strong\u003e The authors thankfully acknowledge the microscopy facility that provided by the PT Dexa Laboratories of Biomolecular Sciences (DLBS)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor details.\u003c/strong\u003e \u003csup\u003e1\u003c/sup\u003eFaculty of Biotechnology, Atma Jaya Catholic University of Indonesia. Jenderal Sudirman 51 Street, South Jakarta, DKI Jakarta, 12930, Indonesia.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003e1. Das S, Dash HR. Microbial-biotechnology: a laboratory manual for bacterial systems. New Delhi: Springer, 2015. p203\u003c/li\u003e\n\u003cli\u003eRabin N, Zheng Y, Opoku TC, Du Y, Bonsu E, Sintim HO. Biofilm formation mechanisms and targets for developing antibiofilm agents. Future Med. Chem. 2015; doi: 10.4155/FMC.15.6.\u003c/li\u003e\n\u003cli\u003eLi Q, Chen X, Jiang Y, Jiang C. 2016. \u003cem\u003eActinobacteria\u003c/em\u003e - Basics and Biotechnological Applications. doi:10.5772/61461\u003c/li\u003e\n\u003cli\u003eScreening of actinomycetes from marine sediments to inhibit \u003cem\u003eVibrio cholerae \u003c/em\u003ebiofilm formation. Biotechnology, Honours [Thesis]. Jakarta (ID): Atma Jaya Catholic University of Indonesia; 2011.\u003c/li\u003e\n\u003cli\u003eVidyawan V. Screening of actinomycetes from various environment sediments to inhibit biofilm formation of \u003cem\u003eVibrio cholerae\u003c/em\u003e. Biotechnology, Honours [Thesis]. Jakarta (ID): Atma Jaya Catholic University of Indonesia; 2013.\u003c/li\u003e\n\u003cli\u003eAbudoleh SM, Mahasneh AM. Anti-quorum sensing activity of substance isolated from wild berry associated bacteria. Avicenna J Medical Biotechnol. 2017;9(1):1-8.\u003c/li\u003e\n\u003cli\u003eRajivgandhi G, Senthil R, Ramachandran G, Manoharan N. Antibiofilm activity of marine endophytic actinomycetes compound isolated from mangrove plant \u003cem\u003eRhizophora mucronata\u003c/em\u003e, Muthupet Mangrove Region, Tamil Nadu, India. J Terr Mar Res. 2018; 2(4):1-7.\u003c/li\u003e\n\u003cli\u003eWaturangi DE, Rahayu BS, Lalu KY, Michael, Mulyono N. Characterization of bioactive compound from actinomycetes from antibiofilm activity against Gram-negative and Gram-positive bacteria. Malays J Microbiol. 2016; doi \u003ca href=\"http://dx.doi.org/10.21161/mjm.80915\"\u003e:10.21161/mjm.80915\u003c/a\u003e.\u003c/li\u003e\n\u003c/ol\u003e\n\u003col start=\"9\"\u003e\n\u003cli\u003eNithya C, Aravindraja C and Pandian SK. 2010. \u003cem\u003eBacillus pumilus\u003c/em\u003e of Palk Bay origin inhibits quorum-sensing-mediated virulence factors in Gram-negative bacteria. Res. Microbiol. 2010; 161 293\u0026ndash;304.\u003c/li\u003e\n\u003cli\u003eNathan P, Law EJ, Murphy DF. A laboratory method for the selection of topical antimicrobial agents to treat infected burn wounds. Burn. 1978; 4.177-17.\u003c/li\u003e\n\u003cli\u003eRajivgandhi G, Vijayan R, Maruthupandy M, Vaseeharan B, Manoharan N. Antibiofilm effect of \u003cem\u003eNocardiopsis\u003c/em\u003e GRG 1 (KT235640) compound against biofilm-forming Gram-negative bacteria on UTIs. Microbial Pathogenis. 2018; \u003ca href=\"https://doi.org/10.1016/j.micpath.2018.03.011\"\u003edoi: 10.1016/j.micpath.2018.03.011\u003c/a\u003e\u003c/li\u003e\n\u003cli\u003eKhan MSA, Zahin M, Hasan S, Husain FM, Ahmad I. Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil. Lett Appl Microbiol. 2009; doi:10.1111/j.1472-765x.2009.02666.x.\u003c/li\u003e\n\u003cli\u003eThenmozhi, R. P., Nithya, J. R. \u0026amp; Pandian, S. K. Antibiofilm activity of coral-associated bacteria against different clinical M serotypes of \u003cem\u003eStreptococcus pyogenes\u003c/em\u003e. FEMS Immunol Med Microbiol. 57, 284-294 (2009).\u003c/li\u003e\n\u003cli\u003eLuo J, Dong B, Wang K, Cai S, Liu T, Cheng X, Lei D, Chen Y, Kong J, Chen Y. Baicalin 263 inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances 264 Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. PLoS 265 ONE. 2017;12(4): e0176883.\u003c/li\u003e\n\u003cli\u003eChen F, Gao Y, Chen X, Yu Z, Li X. Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection. Intl. J. Mol. Sci. 2013; doi:10.3990/IJMS140917477\u003c/li\u003e\n\u003cli\u003eStauff DL, Bassler BL. Quorum Sensing in \u003cem\u003eChromobacterium violaceum\u003c/em\u003e: DNA Recognition and Gene Regulation by the CviR Receptor. J Bacteriol. 2011; doi:10.1128/jb.05125-11.\u003c/li\u003e\n\u003cli\u003eOmran R, Kadhem MF. Production, purification, characterization of bioactive metabolites produced from rare \u003cem\u003eActinobacteria psudonocardia \u003c/em\u003e Asian J Pharm Clin res. 2016; 9(3):264-272.\u003c/li\u003e\n\u003cli\u003eLaSarre B, Federle MJ. Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev. 2013; doi:10.1128/mmbr.00046-12.\u003c/li\u003e\n\u003cli\u003eRodriguez-Saona LE, MM. Giusti, W.D. Robert and W.E. Ronald. Development and process optimization of red radish concentration extract as potential natural red colorant. J Food Process Preserv. 2001; 25: 165\u0026ndash;182.\u003c/li\u003e\n\u003cli\u003eGigu\u0026egrave;re, S, Lee EA, Guldbech KM, Berghaus LJ. \u003cem\u003eIn vitro\u003c/em\u003e synergy, pharmacodynamics, and postantibiotic effect of 11 antimicrobial agents against \u003cem\u003eRhodococcus equi\u003c/em\u003e. Vet Microbiol. 2012; 160(1-2): 207-213.\u003c/li\u003e\n\u003cli\u003eLi, X. H. \u0026amp; Lee, J. H. Antibiofilm agents: a new perspective for antimicrobial strategy. J Microbiol; 10.1007/s12275-017-7274-x (2017).\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"font-size: 11px; line-height: 32px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1 \u0026nbsp;Absorbances of total violacein produced by \u003cem\u003eC. violaceum\u003c/em\u003e CV026\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left: 0.4pt;border-collapse: collapse;\" width=\"624\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5pt;height: 2.7pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eIsolate\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5pt;height: 2.7pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eCV026 + Extract\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5pt;height: 2.7pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eCV026 + Extract + proteinase-K + 95 \u003csup\u003eo\u003c/sup\u003eC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 14pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1AC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 14pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.9770±0.0092\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 14pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.0310±0.0035\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e11AC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.0460±0.0029\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.0260±0.0069\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e14PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.8050±0.046\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.0300±0.0029\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e15PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.8565±0.0020\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.7505±0.0234\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e16PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.8625±0.0026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.1090±0.0012\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e18PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.9190±0.0058\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.1320±0.0035\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e20PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.1760±0.0003\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.8650±0.0115\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eCW01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.1230±0.0012\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.8865±0.0009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eCW17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.6945±0.0430\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e0.9070±0.0046\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eTB12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.1690±0.0018\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.0945±0.0141\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 83.3pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"17.78846153846154%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003eControl\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 134.7pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"28.846153846153847%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.18515±0.0031\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 250pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5pt;height: 13pt;vertical-align: top;\" valign=\"top\" width=\"53.36538461538461%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e1.1845±0.0032\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eCV026 = \u003cem\u003eC. violaceum\u003c/em\u003e CV026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 18.399999618530273px;\"\u003eTable 2 \u0026nbsp; Antibiofilm activity of actinobacteria crude extracts against pathogenic biofilm\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 16.866666793823242px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;text-indent: 0.5in;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 18.399999618530273px;\"\u003e\u0026nbsp; \u0026nbsp;associated bacteria \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\"\u003e\n \u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"width: 491.9pt;border-collapse: collapse;border: none;\" width=\"656\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003ePathogen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eAntibiofilm\n \u003cbr\u003eActivity\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 76.7pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eCrude Extract (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"10\" style=\"width: 297pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e% Activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 11.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e1AC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e11AC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e14PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e15PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e16PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e18PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e20PM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eCW01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eCW17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eTB12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eSA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border-style: solid none none;border-top-width: 1pt;border-top-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e87*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e90*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e90*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n 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26.666664123535156px;\"\u003e77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eBC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n 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26.666664123535156px;\"\u003e85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e90*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e87\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e87\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n 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26.666664123535156px;\"\u003e85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eEF\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e83*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin-right: 0in;margin-bottom: 0.0001pt;margin-left: 0in;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eInhibition\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e84*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eVC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e90\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e94*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e84*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n 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26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eST\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e80\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n 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26.666664123535156px;\"\u003e85*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e80\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e76*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n 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26.666664123535156px;\"\u003e66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003ePA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e54*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e91\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e93*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e87\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eSA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e62*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e77*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 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center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eBC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e75*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e80\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e85*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e83\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eEF\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e52*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin-right: 0in;margin-bottom: 0.0001pt;margin-left: 0in;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eDestruction\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e72*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eVC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e-\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e73*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e62*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eX\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003eST\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 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11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e73*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 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center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e82*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003ePA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border: none;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, 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0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e63*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border: none;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: top;\" valign=\"top\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.7pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 24px;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 11.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e55*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e55*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 11.5pt;vertical-align: bottom;\" valign=\"bottom\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 29.333335876464844px;font-size:15px;font-family: Arial, sans-serif;text-align: center;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: none;\" width=\"9.007633587786259%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"10.83969465648855%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"9.465648854961833%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"6.106870229007634%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.022900763358779%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.175572519083969%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.175572519083969%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.175572519083969%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.175572519083969%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.175572519083969%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.480916030534351%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"7.480916030534351%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"3.3587786259541983%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003ctd style=\"border: none;\" width=\"3.3587786259541983%\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\n \u003cbr\u003e\n \u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 22px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 18px;\"\u003eStaphylococcus aureus\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 18px;\"\u003e\u0026nbsp;ATCC 29213; \u003cem\u003eBacillus cereus\u003c/em\u003e ATCC 14579; \u003cem\u003eEnterococcus faecalis\u003c/em\u003e ATCC 33186, \u003cem\u003eVibrio cholerae\u003c/em\u003e, \u003cem\u003eSalmonella typhimurium\u003c/em\u003e, \u003cem\u003ePseudomonas aeruginosa\u0026nbsp;\u003c/em\u003eATCC 27853.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt;line-height: 22px;font-size:15px;font-family: Arial, sans-serif;text-align: justify;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: \n 11px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 18px;\"\u003e*Highest activity, X Have antimicrobial activity,\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 11px; line-height: 18px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003e- No activity\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Actinobacteria, Antibiofilm, Chromobacterium violaceum , Quorum sensing, Quorum quenching","lastPublishedDoi":"10.21203/rs.2.24412/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.24412/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObjectives:\u0026nbsp;The purpose of the study is to screen antiquorum sensing activity compound from actinobacteria using Chromobacterium violaceum as indicator and quantify the antibiofilm activity against several biofilm-forming pathogenic bacteria, such as Staphylococcus aureus\u0026nbsp;ATCC 29213, Bacillus cereus\u0026nbsp;ATCC 14579, Enterococcus faecalis ATCC 33186, Vibrio cholerae , Salmonella typhimurium , Pseudomonas aeruginosa ATCC 27853.\u003c/p\u003e\u003cp\u003eResults: Crude extracts from marine actinobacteria isolated from Indonesia were promising for treating biofilm-related diseases. Out of 40 isolates 10 were found to have great quorum quenching activity against C. violaceum. Moreover, these isolates were able to inhibit biofim formation by Gram positive\u0026nbsp;and Gram\u0026nbsp;negative pathogenic bacteria. Quorum quenching agents in extracts of 1AC, 14PM, 16PM, 18PM, and CW17 isolates were predicted as proteins or enzymes.\u003c/p\u003e","manuscriptTitle":"Screening and Quantification of Antiquorum-Sensing Activity of Actinobacteria Isolates Against Gram-Positive and Gram-Negative Biofilm Associated Bacteria","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-02-25 16:52:36","doi":"10.21203/rs.2.24412/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"d9dc88a0-78f9-4afc-aa98-947467053b2c","owner":[],"postedDate":"February 25th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":62094,"name":"Bacteriology"}],"tags":[],"updatedAt":"2020-05-29T03:01:15+00:00","versionOfRecord":[],"versionCreatedAt":"2020-02-25 16:52:36","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-14971","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-14971","version":["v1"]},"buildId":"omnImTCwR2MFx8CMYfrG7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}