Retinal Proteome in Neurodegenerative Disorders

Retinal Proteome in Neurodegenerative Disorders | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 12 February 2025 V1 Latest version Share on Retinal Proteome in Neurodegenerative Disorders Authors : Shahab Mirshahvaladi 0000-0002-9145-6155 , Bhakta Prasad Gaire , Sara Assar Kashani , Aparajeeta Guha , Yosef Koronyo , Dieu-Trang Fuchs , Yuyi You , … Show All … , Keith L Black , Joao Paulo 0000-0002-4291-413X , Stuart Graham , Vivek Gupta , Mehdi Mirzaei 0000-0001-8727-4984 , and Maya Koronyo-Hamaoui [email protected] Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.173937806.64509959/v1 376 views 147 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Dysregulated proteostasis in the retina represents a promising avenue for discovering novel therapeutic targets and diagnostic biomarkers for neurodegenerative diseases with ocular manifestations. Advanced mass spectrometry-based proteomics techniques have shown considerable potential in investigating the retinal proteome in diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, as well as Alzheimer’s disease (AD), amyotrophic lateral sclerosis, and Parkinson’s disease. Recent proteomics innovations are overcoming challenges such as limited sample size and protein coverage that previously hindered comprehensive retinal proteome analysis. Notably, the incorporation of artificial intelligence (AI)-driven computational pipelines, including GPU-accelerated deep learning architectures, has markedly enhanced the precision and effectiveness of retinal proteomics. These advances facilitate high-resolution identification of novel protein signatures within large-scale multi-omics datasets. Furthermore, the integration of advanced AI with state-of-the-art big data infrastructures supports the early detection of biomarkers in neurodegenerative diseases with ocular involvement, offering unprecedented disease specificity and sensitivity. In addition to these computational strides, emerging complementary and alternative technologies continue to provide valuable tools for retinal analysis, expanding the potential for biomarker discovery in both ophthalmic and neurodegenerative disorders. The development of novel proteomic workflows is expected to play a critical role in advancing biomarker discovery, not only for ophthalmic conditions but also for other neurodegenerative diseases, including AD. This review summarizes recent advancements in retinal proteomics, with a particular focus on neurodegenerative and ocular diseases. Supplementary Material File (retina nd proteomics_final.docx) Download 6.24 MB Information & Authors Information Version history V1 Version 1 12 February 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords age-related macular degeneration biomarker discovery diabetic r glaucoma mechanism of disease neurodegeneration proteomics Authors Affiliations Shahab Mirshahvaladi 0000-0002-9145-6155 Macquarie University View all articles by this author Bhakta Prasad Gaire Cedars-Sinai Medical Center Department of Neurosurgery View all articles by this author Sara Assar Kashani View all articles by this author Aparajeeta Guha View all articles by this author Yosef Koronyo View all articles by this author Dieu-Trang Fuchs View all articles by this author Yuyi You Macquarie University View all articles by this author Keith L Black View all articles by this author Joao Paulo 0000-0002-4291-413X Harvard Medical School View all articles by this author Stuart Graham Macquarie University View all articles by this author Vivek Gupta Macquarie University View all articles by this author Mehdi Mirzaei 0000-0001-8727-4984 Macquarie University View all articles by this author Maya Koronyo-Hamaoui [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 376 views 147 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Shahab Mirshahvaladi, Bhakta Prasad Gaire, Sara Assar Kashani, et al. Retinal Proteome in Neurodegenerative Disorders. Authorea . 12 February 2025. DOI: https://doi.org/10.22541/au.173937806.64509959/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! 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