68Ga-OncoFAP-targeted PET/MRI for endometriosis assessment – initial results

This retrospective study evaluated the feasibility of integrated 68Ga-OncoFAP–targeted PET/MRI for endometriosis detection in nine premenopausal women with confirmed endometriosis and nine premenopausal women without known disease, using semi-quantitative assessment and modified #ENZIAN segmentation with clinical assessment or laparoscopy as the reference standard. PET/MRI identified more likely endometriotic findings than MRI alone, with 45/91 segments (49.5%) vs 17/91 segments (18.7%) flagged as likely endometriotic, and PET/CT or PET/MRI showed focal tracer uptake in 44/108 segments (40.7%) in the endometriosis group versus 14/108 (13.0%) in controls (p<0.01). The authors note an important limitation of the small sample size and that reference standards were not uniformly available for all participants. This paper is centrally about endometriosis — it tests 68Ga-OncoFAP PET/MRI to improve noninvasive detection, especially in anatomically challenging regions.

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