Effectiveness of the air-filled technique to reduce the dead space in syringes and needles during ChAdox1-n CoV vaccine administration

In the current study, we calculated the vaccine volume and amount of dead space in a syringe and needle during ChAdox1-n CoV vaccine administration using the air-filled technique, to reduce dead space in syringe and needle that administer up to 12 doses per vial. The hypothetical situation uses a vial with a similar size as the ChAdox1-n CoV vial. We used distilled water (6.5 ml), to fill the same volume as five vials of ChAdox1-n CoV. When 0.48 ml of distilled water is drawn according to the number on the side of the barrel, an additional 0.10 ml of air can be used in the dead space of the distilled water in the syringe and needle for 60 doses, which can be divided into an average of 0.5 ml dose. ChAdox1-n CoV was administered using a 1-mL syringe and 25G needle to administer ChAdox1-n CoV vaccine into 12 doses using this air-filled technique. The volume of the recipient vaccine will be increase by 20% and save the budget of a low dead space syringe (LDS). Graphical Abstract