The therapeutic effects of mifepristone on endometriosis compared with danazol

Objective To investigate the therapeutic effects and side effects of mifepristone on endometriosis.Methods Ninty patients suffering from endometriosis were selected and divided non-randomly into A and B groups.Group A was administered tablets of mifepristone 25 mg q.d,whereas Group B was administered tablets of danazol 200 mg,bid or tid,for 6 months and followed up for 6~30months.Results For group A the remossion rate of symptoms was 95.6%,remission rate of physical signs was 75.6%,the pregnancy rate was 69.2%,and the recurrence rate was 31.8%.The group B was 97.5%,80.0%,71.4%,42.6%respectively.The differences in therapeutic effects and recurrence rate between the two groups did not have any statistic significance.The weight gain rate and abnormal rate of ALT of group A were 6.6% and 2.2% separately,and group B was 95.6% and 42.2% respectively.The differences in the two groups had obvious statistic significance.Conclusion Mifepristone was similar to danazol in the therapeutic effects on endomatriosis,but mifepristone has fewer side effects and was widely applied in clinical treatment.