In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

2020 · doi:10.26434/chemrxiv.12994004.v1
preprint OA: closed CC-BY-NC-ND-4.0
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Abstract

This work describes the in vitro binding of CB[8] and Me4CB[8] toward a panel of 10 drugs of abuse, and in vitro and in vivo assays to demonstrate the biocompatibility of Me4CB[8]. In vivo efficacy studies show that Me4CB[8] can control the hyper locomotion of animals treated with PCP.

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License: CC-BY-NC-ND-4.0