A double network composite hydrogel with enhanced transdermal delivery by ultrasound for endometrial injury repair and fertility recovery

Xin Zhang, Shufang Wang, S. Wang, Zeyi Long, Cong Lu, Jianlin Wang, Lijun Yang, Cancan Yao, Bin He, Xihua Chen, Taifeng Zhuang, Xiangbo Xu, Yufeng Zheng
In: Bioactive Materials · 2025 · vol. 50 , pp. 273–286 · doi:10.1016/j.bioactmat.2025.04.007 · PMID:40270550 · W4409431324
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study demonstrates a composite hydrogel and ultrasound treatment effectively promotes endometrial regeneration, reduces fibrosis, and restores fertility in a rat model by enhancing transdermal delivery.

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Abstract

experiments demonstrated that CSMA-RC-Zn-PNS exhibits excellent biosafety, biodegradability, and promotes cell proliferation, migration, and tube formation, along with antioxidant and antibacterial properties. In a rat endometrial injury model, the ultrasound cavitation effect was demonstrated to enhance transdermal delivery efficiency, and the ability of CSMA-RC-Zn-PNS to promote endometrial regeneration, anti-fibrosis and fertility restoration was verified. Overall, this strategy combining CSMA-RC-Zn-PNS hydrogel and ultrasound treatment shows promising applications in endometrial regeneration and female reproductive health.

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last seen: 2026-06-04T00:00:01.174412+00:00
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