Bardet-biedl Syndrome With Ttc8 Mutation in a Kenyan Adolescent: A Case Report From a Rural Public Hospital

Bardet-biedl Syndrome With Ttc8 Mutation in a Kenyan Adolescent: A Case Report From a Rural Public Hospital | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Bardet-biedl Syndrome With Ttc8 Mutation in a Kenyan Adolescent: A Case Report From a Rural Public Hospital Phoebe Wamalwa, Joan Kwamboka, Rebecca Oenga This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7493665/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 5 You are reading this latest preprint version Abstract Bardet-Biedl syndrome (BBS) is a rare inherited disorder of ciliopathy characterized by dysfunction of primary cilia resulting in a myriad of manifestations in various organ systems. These manifestations include progressive retinal dystrophy, central obesity, polydactyly, mental retardation, hypogonadism, and renal dysfunction. Additional manifestations include, but are not limited to, hypertension, diabetes mellitus, congenital heart disease, hepatic fibrosis, asthma and neurological features, illustrating the complexity of its clinical spectrum. The clinical features of BBS patients are widely shared with those of patients suffering from other ciliopathies, especially autosomal recessive syndromic disorders. Moreover, mutations in cilia-related genes can cause different ciliopathies. Herein, we report a case of a 14-year-old boy with progressive vision loss, mental retardation, delayed puberty as well as toe and finger abnormalities. Genetic tests confirmed Bardet-Biedl syndrome. The caregiver was offered genetic counselling and the boy was started on supportive management, including puberty induction. Bardet-Biedl syndrome ciliopathy vision loss retardation obesity delayed puberty mutation Figures Figure 1 Figure 2 Figure 3 Figure 4 INTRODUCTION Bardet-Biedl syndrome (BBS) is an inherited disorder affecting multiple organs and systems. Its mode of inheritance is autosomal recessive. However, it is common to have non affected parents. [ 1 ] It is a rare condition with a wide geographical variation. In North America and Europe, for instance, it ranges between 1:120.000 and 1:160.000 individuals [ 1 ] while in certain communities, due to the high prevalence of consanguineous marriages, the frequency is much higher, varying between: 1:3700 and 1;36,000. [ 2 – 3 ]. BBS arises from a defect in the BBS genes that code for several ciliary-related proteins. Therefore, it is categorized as a ciliopathy disorder that occurs because of ciliary dysgenesis and dysfunction [ 4 ] Normally, there is an interaction between BBS proteins, which include BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP1, and the primary cilia, with the help of chaperonin-like proteins, BBS6, BBS10 and BBS12 to form a BBSome complex. Primary cilia play a significant role in several signalling pathways that regulate pivotal cellular functions, including cell division of cells, cellular polarity, and metabolism [ 4 ]. The formed BBsomes complex links to the BBS3 GTPase protein, allowing intraflagellar transport. In contrast the link to BBS17 maintains the BBSome at the basal body level. Various complexes, including IFT-A and IFT-B (which includes BBS19 and BBS20) mediate retrograde trafficking and anterograde trafficking of cilia, respectively. BBS11, on the other hand favors protein ubiquitination [ 4 ]. The diagnosis of BBS is based on clinical criteria recommended by Beales et al [ 5 ]. It requires the presence of at least four primary diagnostic features or three primary features and two secondary features. Primary diagnostic features include, retinal degeneration, obesity, postaxial polydactyly, renal abnormalities, learning disabilities, hypogonadism and genitourinary abnormalities. Secondary features include, strabismus, cataracts, and astigmatism, metabolic/endocrine abnormalities, brachydactyly/syndactyly, anosmia/olfactory dysfunction, neurodevelopmental abnormalities, liver and other gastrointestinal diseases, cardiovascular and thoraco-abdominal abnormalities. Described BBS features not included in the diagnostic criteria include, cutaneous dermatoses, hearing loss, asthma, dysregulated immune and hematopoietic systems, and musculoskeletal abnormalities [ 6 ]. Negative family history for BBS is common, as shown in other autosomal recessive disorders. Furthermore, early diagnosis is hard, because of the progressive onset of all clinical signs over time. Beales et al. showed that the average age at diagnosis was 9 years, while the mean age at symptoms onset was 3 years (6). In this case we shall discuss the report of a 14-year-old boy who presented with progressive visual loss, delayed puberty, digit abnormalities and obesity among other organ abnormalities. CASE REPORT Herein, we report a case of a 14-year-old Somali boy born to consanguineous parents (first cousins). He was referred to the ophthalmologist after a teacher noticed learning difficulties and frequent bumping into objects for four years prior to review. Examination revealed obesity, polydactyly, syndactyly, and poor vision with retinal changes consistent with retinitis pigmentosa, raising suspicion for syndromic-associated retinitis pigmentosa. He was subsequently referred to the pediatric endocrinologist. He was noted to have learning difficulties based on school performance rather than standardized testing. Appetite was normal, with no history of anosmia or hyposmia. The family’s other main concern was lack of pubertal signs, no pubic hair or genital growth, raising suspicion of delayed puberty. He is the third of four siblings; a younger brother also has learning disabilities, obesity, and visual impairment but was not reviewed as he resides in another country with the parents. On examination, he was in fair general condition, with no pallor, edema, cyanosis, nor jaundice. Vital signs were normal: blood pressure 109/69 mmHg, pulse 78 bpm, and respiratory rate 26/min. He weighed 69 kg (90th–97th percentile), measured 159.5 cm in height (25th percentile), with a BMI of 27.3 (> 95th percentile). Head circumference was 52.2 cm (10th percentile). There were no thoraco-abdominal abnormalities and no organomegaly. Stretched penile length measured 4.5 cm (< P3) with bilaterally prepubertal descended testes (3 mL each), assessed using an orchidometer, and absence of pubic hair. Laboratory tests showed normal complete blood count and renal function, but deranged liver and thyroid function (central hypothyroidism), along with low morning cortisol. Luteinizing and follicle-stimulating hormones with low testosterone indicated hypogonadism, Table 1 . HbA1c was 5.2% with normal fasting blood glucose. Given the likelihood of panhypopituitarism, growth hormone deficiency evaluation would have been appropriate but was not initiated due to financial constraints. Table 1 Laboratory tests Test LH (IU/L) FSH (IU/L) Testosterone (nmol/L) TSH (mIU/L) FT4 (ng/dl) FT3 (pmol/L) 8 am cortisol (nmol/L) Albumin (g/L) ALP (U/L) Total protein (g/dl) Normal ranges 0.57–12.07 0.95-12.0 8–30 0.5- 5.0 0.9–1.7 3.1–6.8 171–536 38–51 80–306 66–87 Result 0.1 2.25 1.06 2.34 0.85 3.77 123.5 29.64 808 44.23 Renal ultrasound was normal. The Bone age showed a delay at 10 years. Echocardiography showed good biventricular systolic and diastolic function with an LVEF of 63%, no regional wall motion abnormalities, and was essentially normal. Brain MRI, including pituitary protocol, was also normal. Ocular examination revealed severely impaired vision, counting fingers at 1 meter in the right eye and hand motion in the left, accompanied by horizontal nystagmus and poor fixation. Fundoscopy demonstrated features of retinitis pigmentosa, including bony spicule pigmentation and areas of atrophy, Fig. 4 . Genetic analysis identified a mutation in the TTC8 gene (NM_144596.4), which encodes the BBS8 protein, a component of the BBSome complex (Table 5 ). Table 5: Genetic analysis report showing TTC8 mutation Based on the clinical findings, our patient met four primary diagnostic criteria for Bardet-Biedl syndrome [ 5 ]: retinal degeneration, obesity, postaxial polydactyly, learning disabilities, and hypogonadism. He also exhibited secondary features, including central obesity, acanthosis nigricans, panhypopituitarism, brachydactyly, syndactyly, ataxia, and deranged liver function tests, as well as additional cutaneous dermatoses not listed in the criteria. No renal, cardiac, or thoracic abnormalities were present. Genetic testing confirmed Bardet-Biedl syndrome through identification of a TTC8 gene (NM_144596.4) mutation encoding the BBS8 protein of the BBSome complex. Management included genetic counseling, a nutritional plan for weight reduction, and psychosocial support for coping with sight loss. Hormone replacement therapy was initiated with hydrocortisone (6–8 mg/kg/day in three divided doses: half at 6:00 am, a quarter at 2:00 pm, and a quarter at 8:00 pm), followed by levothyroxine 50 µg once daily. Subsequently, plans were made for puberty induction with intramuscular testosterone 50 mg monthly and surgical excision of the extra digits. However, the patient was lost to follow-up before these treatments were initiated. Ophthalmological care included low vision assessment, mobility and orientation training, and school placement with plans to introduce Braille education. CASE DISCUSSION Bardet–Biedl syndrome (BBS) is a rare multisystem ciliopathy characterized by a constellation of primary and secondary features. According to Beales et al., diagnosis requires four primary features or three primaries plus two secondary features [ 5 ]. Our patient met five primary criteria, retinal dystrophy, obesity, postaxial polydactyly, learning disabilities, and hypogonadism and several secondary features. This article will discuss selected primary features that our patient presented with. Retinal Dystrophy Retinal dystrophy is the most penetrant manifestation of BBS, affecting nearly all individuals [ 7 ]. The predominant pattern is rod–cone dystrophy with early macular involvement [ 7 , 8 ]. Symptoms usually begin with nyctalopia in early childhood, followed by progressive peripheral vision loss, and eventual decline in color vision and central acuity. Most patients reach legal blindness by the third decade of life [ 9 ]. Fundoscopy typically reveals bone spicule pigmentation, attenuated retinal vessels, and a waxy pale optic disc [ 9 , 10 ]. The pathogenesis involves impaired rhodopsin trafficking and endoplasmic reticulum stress responses in ciliary models [ 8 , 11 ]. Our patient presented at age 14 with poor fixation, horizontal nystagmus, and fundoscopy findings consistent with retinitis pigmentosa, including spicule pigmentation and retinal atrophy. The visual loss was progressive having started manifesting symptoms at the age of 9 years. Obesity Obesity is reported in 72–92% of cases and typically develops within the first three years of life [ 1 , 5 ]. While diffuse in childhood, truncal distribution predominates in adults. Pathogenesis includes defective leptin signaling in POMC neurons, resulting in leptin resistance. BBS proteins also influence preadipocyte differentiation through Wnt and Hedgehog pathways [ 12 , 13 ] and regulate insulin receptor trafficking, with disruption leading to insulin resistance [ 14 ]. Our patient had BMI > 95th percentile, with striae and acanthosis nigricans, indicating insulin resistance despite normal HbA1c. Postaxial Polydactyly Polydactyly occurs in 63–81% of BBS patients [ 1 ]. It is attributed to impaired Sonic Hedgehog (Shh) signaling during limb development [ 5 ]. Digits may be fully formed and involve hands, feet, or both. Secondary skeletal anomalies include brachydactyly, syndactyly, and clinodactyly [ 5 ]. Our patient had six digits and syndactyly on both hands, plus an extra toe on the right foot with brachydactyly. Renal Involvement Renal abnormalities contribute significantly to morbidity and mortality in BBS. Forsythe et al. reported chronic kidney disease in 31% of children and 42% of adults [ 11 ]. Manifestations include structural malformations, cystic dysplasia, and progressive CKD [ 15 , 16 ]. Meyer et al. identified renal failure in 7.2% of genetically confirmed patients, with BBS2 and BBS10 mutations conferring highest risk [ 11 ]. Mechanisms include metabolic dysfunction and mitochondrial abnormalities [ 17 ]. Our patient had normal renal ultrasound, function tests, and urinalysis, with no polyuria. Learning Disabilities Cognitive impairment is reported in 60–66% of patients [ 18 ]. MRI studies demonstrate hippocampal and cortical volume loss, while speech delay and motor dysfunction are common [ 18 ]. Our patient exhibited learning difficulties, slurred speech, and ataxia, though brain and pituitary MRI were reported as normal. Hypogonadism and Genitourinary Abnormalities get references Hypogonadism occurs in approximately 59% of cases [ 1 , 19 ], presenting as delayed puberty, cryptorchidism, micropenis, or gonadal dysgenesis. Female patients may develop menstrual irregularities or polycystic ovaries [ 19 , 20 ]. Mujahid et al. reported hypogonadism in 19.5% of males, with pituitary anomalies uncommon [ 18 ]. Our patient had reduced penile length, prepubertal descended testes, absent pubic hair, and low testosterone with hypogonadotropic hypogonadism as confirmed by low luteinizing and follicle stimulating hormones. Secondary Features Secondary features of BBS arise from ciliary dysfunction affecting multiple systems. In our patient, acanthosis nigricans and pigmentary dermatoses reflect insulin resistance; central hypothyroidism and low cortisol result from hypothalamic–pituitary involvement; deranged liver enzymes reflect impaired bile duct development predisposing to hepatic dysfunction; and the high-arched palate stems from abnormal craniofacial morphogenesis [ 1 , 5 ]. Genetic Findings The most common mutations occur in BBS1 and BBS10, each accounting for approximately 20% of cases [ 1 , 4 , 21 ], while TTC8 mutations are rare (~ 2%) and may present with syndromic or isolated retinal degeneration [ 19 – 21 ]. Genetic analysis in our patient confirmed a TTC8 mutation, thereby establishing the diagnosis. Conclusion This first case reported from a rural public hospital highlights the importance of early recognition of rare syndromes such as BBS. A high index of suspicion, particularly in patients presenting with retinitis pigmentosa and obesity, coupled with timely referral, enabled accurate diagnosis and genetic confirmation. Multidisciplinary management remains essential. Although prognosis is guarded, early identification can guide supportive interventions and genetic counselling. Greater awareness among healthcare workers is needed to facilitate prompt diagnosis and care. Case limitation The patient was lost to follow-up before initiation of some planned interventions (e.g., puberty induction with testosterone, surgical excision of extra digits). This limited the ability to document treatment outcomes and long-term prognosis. While hypogonadism and central hypothyroidism were identified, adrenocorticotropic hormone (ACTH) was not tested due to financial constraints, which may have provided additional clarity on pituitary function. Some recommended tests such as electroretinography and formal neurocognitive assessment were not performed, which restricted full phenotypic characterization. Although a TTC8 mutation was identified in the patient, segregation analysis in other family members was not conducted. This could have provided stronger confirmation and insight into inheritance patterns. As an isolated case, findings cannot be generalized to all patients with BBS, particularly given genetic and phenotypic heterogeneity. Declarations Ethical Compliance: Written consent was obtained from the mother, and assent was provided by the 14-year-old patient. Author Contributions: All three authors contributed to the clinical review, patient management, and manuscript preparation of this case report Conflicts of Interest: The authors declare no conflicts of interest. Funding: No funding was received for this report. Data Availability The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Use of Large Language Models, AI, and Machine Learning Tools: None declared. References Beales PL, Warner AM, Hitman GA, Thakker R, Flinter FA. Bardet-Biedl syndrome: a molecular and phenotypic study of 18 families. J Med Genet. 1997;34(2):92–8. Moore SJ, Green JS, Fan Y, et al. Clinical and genetic epidemiology of Bardet-Biedl syndrome in newfoundland: a 22-year prospective, population-based, cohort study. Am J Med Genet A. 2005;132A(4):352–60. Hjortshøj TD, Grønskov K, Brøndum-Nielsen K, Rosenberg T. A novel founder BBS1 mutation explains a unique high prevalence of Bardet-Biedl syndrome in the Faroe Islands. Br J Ophthalmol. 2009;93(3):409–13. Gupta N, D’Acierno M, Zona E, Capasso G, Zacchia M. Bardet-Biedl syndrome: the pleiotropic role of the chaperonin-like BBS6, 10, and 12 proteins. 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The endocrine and metabolic characteristics of a large Bardet-Biedl syndrome clinic population. J Clin Endocrinol Metab. 2018;103(5):1834–41. Katsanis N. The oligogenic properties of Bardet–Biedl syndrome. Hum Mol Genet. 2004;13:R65–71. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 24 Sep, 2025 Reviewers agreed at journal 08 Sep, 2025 Reviewers invited by journal 08 Sep, 2025 Editor assigned by journal 03 Sep, 2025 First submitted to journal 01 Sep, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7493665","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":512135541,"identity":"1cd1a7cc-9d04-44da-b068-baa951bd3c44","order_by":0,"name":"Phoebe 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17:42:40","extension":"html","order_by":23,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":65623,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-7493665/v1/ced3dfe4d1891fcaf60cdce6.html"},{"id":92063276,"identity":"5ca5cbcd-3ec6-44b7-a311-2e179b06d132","added_by":"auto","created_at":"2025-09-24 08:37:43","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":229736,"visible":true,"origin":"","legend":"\u003cp\u003eSee image above for figure legend.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","description":"","filename":"Fig1BBScase1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7493665/v1/66eafbc672bbdf12dcbcd55e.jpg"},{"id":92020312,"identity":"767e165a-2850-48c7-a8e0-f5ee701c35f0","added_by":"auto","created_at":"2025-09-23 17:34:40","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":231799,"visible":true,"origin":"","legend":"\u003cp\u003eSee image above for figure legend.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","description":"","filename":"Fig1BBScase2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7493665/v1/10865b9923432d8340e10c26.jpg"},{"id":92020310,"identity":"e0ecfa1c-7f9c-4c93-a081-28fdaa687bd9","added_by":"auto","created_at":"2025-09-23 17:34:40","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":198113,"visible":true,"origin":"","legend":"\u003cp\u003eSee image above for figure legend.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","description":"","filename":"Fig1BBScase3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7493665/v1/f51ae04e03ebbfd854cc8741.jpg"},{"id":92020317,"identity":"9aff7acb-6208-44e7-98c1-8f23873bacac","added_by":"auto","created_at":"2025-09-23 17:34:40","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":226113,"visible":true,"origin":"","legend":"\u003cp\u003eSee image above for figure legend.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","description":"","filename":"Fig1BBScase4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7493665/v1/a430a1e1bf2b875033184507.jpg"},{"id":92063419,"identity":"58aac46f-b5d3-491d-b7dd-0cb5d9f99b0d","added_by":"auto","created_at":"2025-09-24 08:38:18","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1332828,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7493665/v1/a26ac53d-c862-407c-8828-3ce7cecf93a6.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eBardet-biedl Syndrome With Ttc8 Mutation in a Kenyan Adolescent: A Case Report From a Rural Public Hospital\u003c/p\u003e","fulltext":[{"header":"INTRODUCTION","content":"\u003cp\u003eBardet-Biedl syndrome (BBS) is an inherited disorder affecting multiple organs and systems. Its mode of inheritance is autosomal recessive. However, it is common to have non affected parents. [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] It is a rare condition with a wide geographical variation. In North America and Europe, for instance, it ranges between 1:120.000 and 1:160.000 individuals [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] while in certain communities, due to the high prevalence of consanguineous marriages, the frequency is much higher, varying between: 1:3700 and 1;36,000. [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eBBS arises from a defect in the BBS genes that code for several ciliary-related proteins. Therefore, it is categorized as a ciliopathy disorder that occurs because of ciliary dysgenesis and dysfunction [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e] Normally, there is an interaction between BBS proteins, which include BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP1, and the primary cilia, with the help of chaperonin-like proteins, BBS6, BBS10 and BBS12 to form a BBSome complex. Primary cilia play a significant role in several signalling pathways that regulate pivotal cellular functions, including cell division of cells, cellular polarity, and metabolism [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. The formed BBsomes complex links to the BBS3 GTPase protein, allowing intraflagellar transport. In contrast the link to BBS17 maintains the BBSome at the basal body level. Various complexes, including IFT-A and IFT-B (which includes BBS19 and BBS20) mediate retrograde trafficking and anterograde trafficking of cilia, respectively. BBS11, on the other hand favors protein ubiquitination [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eThe diagnosis of BBS is based on clinical criteria recommended by Beales et al [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. It requires the presence of at least four primary diagnostic features or three primary features and two secondary features. Primary diagnostic features include, retinal degeneration, obesity, postaxial polydactyly, renal abnormalities, learning disabilities, hypogonadism and genitourinary abnormalities. Secondary features include, strabismus, cataracts, and astigmatism, metabolic/endocrine abnormalities, brachydactyly/syndactyly, anosmia/olfactory dysfunction, neurodevelopmental abnormalities, liver and other gastrointestinal diseases, cardiovascular and thoraco-abdominal abnormalities. Described BBS features not included in the diagnostic criteria include, cutaneous dermatoses, hearing loss, asthma, dysregulated immune and hematopoietic systems, and musculoskeletal abnormalities [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eNegative family history for BBS is common, as shown in other autosomal recessive disorders. Furthermore, early diagnosis is hard, because of the progressive onset of all clinical signs over time. Beales et al. showed that the average age at diagnosis was 9 years, while the mean age at symptoms onset was 3 years (6). In this case we shall discuss the report of a 14-year-old boy who presented with progressive visual loss, delayed puberty, digit abnormalities and obesity among other organ abnormalities.\u003c/p\u003e"},{"header":"CASE REPORT","content":"\u003cp\u003eHerein, we report a case of a 14-year-old Somali boy born to consanguineous parents (first cousins). He was referred to the ophthalmologist after a teacher noticed learning difficulties and frequent bumping into objects for four years prior to review. Examination revealed obesity, polydactyly, syndactyly, and poor vision with retinal changes consistent with retinitis pigmentosa, raising suspicion for syndromic-associated retinitis pigmentosa. He was subsequently referred to the pediatric endocrinologist. He was noted to have learning difficulties based on school performance rather than standardized testing. Appetite was normal, with no history of anosmia or hyposmia. The family\u0026rsquo;s other main concern was lack of pubertal signs, no pubic hair or genital growth, raising suspicion of delayed puberty.\u003c/p\u003e\n\u003cp\u003eHe is the third of four siblings; a younger brother also has learning disabilities, obesity, and visual impairment but was not reviewed as he resides in another country with the parents.\u003c/p\u003e\n\u003cp\u003eOn examination, he was in fair general condition, with no pallor, edema, cyanosis, nor jaundice. Vital signs were normal: blood pressure 109/69 mmHg, pulse 78 bpm, and respiratory rate 26/min. He weighed 69 kg (90th\u0026ndash;97th percentile), measured 159.5 cm in height (25th percentile), with a BMI of 27.3 (\u0026gt;\u0026thinsp;95th percentile). Head circumference was 52.2 cm (10th percentile).\u003c/p\u003e\n\u003cp\u003eThere were no thoraco-abdominal abnormalities and no organomegaly. Stretched penile length measured 4.5 cm (\u0026lt;\u0026thinsp;P3) with bilaterally prepubertal descended testes (3 mL each), assessed using an orchidometer, and absence of pubic hair. Laboratory tests showed normal complete blood count and renal function, but deranged liver and thyroid function (central hypothyroidism), along with low morning cortisol. Luteinizing and follicle-stimulating hormones with low testosterone indicated hypogonadism, Table\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e. HbA1c was 5.2% with normal fasting blood glucose. Given the likelihood of panhypopituitarism, growth hormone deficiency evaluation would have been appropriate but was not initiated due to financial constraints.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003ctable id=\"Tab1\" border=\"1\"\u003e\n \u003ccaption language=\"En\"\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eLaboratory tests\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eTest\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eLH (IU/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eFSH (IU/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eTestosterone (nmol/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eTSH (mIU/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eFT4 (ng/dl)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eFT3 (pmol/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e8 am cortisol (nmol/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eAlbumin\u003c/p\u003e\n \u003cp\u003e(g/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eALP\u003c/p\u003e\n \u003cp\u003e(U/L)\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eTotal protein (g/dl)\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNormal ranges\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.57\u0026ndash;12.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.95-12.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8\u0026ndash;30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.5- 5.0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.9\u0026ndash;1.7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e3.1\u0026ndash;6.8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e171\u0026ndash;536\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e38\u0026ndash;51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80\u0026ndash;306\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e66\u0026ndash;87\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eResult\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e3.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e123.5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e808\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e44.23\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eRenal ultrasound was normal. The Bone age showed a delay at 10 years. Echocardiography showed good biventricular systolic and diastolic function with an LVEF of 63%, no regional wall motion abnormalities, and was essentially normal. Brain MRI, including pituitary protocol, was also normal.\u003c/p\u003e\n\u003cp\u003eOcular examination revealed severely impaired vision, counting fingers at 1 meter in the right eye and hand motion in the left, accompanied by horizontal nystagmus and poor fixation. Fundoscopy demonstrated features of retinitis pigmentosa, including bony spicule pigmentation and areas of atrophy, Fig. \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e.\u003c/p\u003e\n\u003cp\u003eGenetic analysis identified a mutation in the TTC8 gene (NM_144596.4), which encodes the BBS8 protein, a component of the BBSome complex (Table \u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\"\u003e\u003c/p\u003e\n\u003cp\u003eTable 5: Genetic analysis report showing TTC8 mutation \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eBased on the clinical findings, our patient met four primary diagnostic criteria for Bardet-Biedl syndrome [\u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e]: retinal degeneration, obesity, postaxial polydactyly, learning disabilities, and hypogonadism. He also exhibited secondary features, including central obesity, acanthosis nigricans, panhypopituitarism, brachydactyly, syndactyly, ataxia, and deranged liver function tests, as well as additional cutaneous dermatoses not listed in the criteria. No renal, cardiac, or thoracic abnormalities were present. Genetic testing confirmed Bardet-Biedl syndrome through identification of a TTC8 gene (NM_144596.4) mutation encoding the BBS8 protein of the BBSome complex.\u003c/p\u003e\n\u003cp\u003eManagement included genetic counseling, a nutritional plan for weight reduction, and psychosocial support for coping with sight loss. Hormone replacement therapy was initiated with hydrocortisone (6\u0026ndash;8 mg/kg/day in three divided doses: half at 6:00 am, a quarter at 2:00 pm, and a quarter at 8:00 pm), followed by levothyroxine 50 \u0026micro;g once daily. Subsequently, plans were made for puberty induction with intramuscular testosterone 50 mg monthly and surgical excision of the extra digits. However, the patient was lost to follow-up before these treatments were initiated. Ophthalmological care included low vision assessment, mobility and orientation training, and school placement with plans to introduce Braille education.\u003c/p\u003e"},{"header":"CASE DISCUSSION","content":"\u003cp\u003eBardet\u0026ndash;Biedl syndrome (BBS) is a rare multisystem ciliopathy characterized by a constellation of primary and secondary features. According to Beales et al., diagnosis requires four primary features or three primaries plus two secondary features [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Our patient met five primary criteria, retinal dystrophy, obesity, postaxial polydactyly, learning disabilities, and hypogonadism and several secondary features. This article will discuss selected primary features that our patient presented with.\u003c/p\u003e\u003cp\u003eRetinal Dystrophy\u003c/p\u003e\u003cp\u003eRetinal dystrophy is the most penetrant manifestation of BBS, affecting nearly all individuals [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. The predominant pattern is rod\u0026ndash;cone dystrophy with early macular involvement [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Symptoms usually begin with nyctalopia in early childhood, followed by progressive peripheral vision loss, and eventual decline in color vision and central acuity. Most patients reach legal blindness by the third decade of life [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. Fundoscopy typically reveals bone spicule pigmentation, attenuated retinal vessels, and a waxy pale optic disc [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]. The pathogenesis involves impaired rhodopsin trafficking and endoplasmic reticulum stress responses in ciliary models [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Our patient presented at age 14 with poor fixation, horizontal nystagmus, and fundoscopy findings consistent with retinitis pigmentosa, including spicule pigmentation and retinal atrophy. The visual loss was progressive having started manifesting symptoms at the age of 9 years.\u003c/p\u003e\u003cp\u003eObesity\u003c/p\u003e\u003cp\u003eObesity is reported in 72\u0026ndash;92% of cases and typically develops within the first three years of life [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. While diffuse in childhood, truncal distribution predominates in adults. Pathogenesis includes defective leptin signaling in POMC neurons, resulting in leptin resistance. BBS proteins also influence preadipocyte differentiation through Wnt and Hedgehog pathways [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e] and regulate insulin receptor trafficking, with disruption leading to insulin resistance [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. Our patient had BMI\u0026thinsp;\u0026gt;\u0026thinsp;95th percentile, with striae and acanthosis nigricans, indicating insulin resistance despite normal HbA1c.\u003c/p\u003e\u003cp\u003ePostaxial Polydactyly\u003c/p\u003e\u003cp\u003ePolydactyly occurs in 63\u0026ndash;81% of BBS patients [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. It is attributed to impaired Sonic Hedgehog (Shh) signaling during limb development [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Digits may be fully formed and involve hands, feet, or both. Secondary skeletal anomalies include brachydactyly, syndactyly, and clinodactyly [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Our patient had six digits and syndactyly on both hands, plus an extra toe on the right foot with brachydactyly.\u003c/p\u003e\u003cp\u003eRenal Involvement\u003c/p\u003e\u003cp\u003eRenal abnormalities contribute significantly to morbidity and mortality in BBS. Forsythe et al. reported chronic kidney disease in 31% of children and 42% of adults [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Manifestations include structural malformations, cystic dysplasia, and progressive CKD [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. Meyer et al. identified renal failure in 7.2% of genetically confirmed patients, with BBS2 and BBS10 mutations conferring highest risk [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Mechanisms include metabolic dysfunction and mitochondrial abnormalities [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. Our patient had normal renal ultrasound, function tests, and urinalysis, with no polyuria.\u003c/p\u003e\u003cp\u003eLearning Disabilities\u003c/p\u003e\u003cp\u003eCognitive impairment is reported in 60\u0026ndash;66% of patients [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. MRI studies demonstrate hippocampal and cortical volume loss, while speech delay and motor dysfunction are common [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. Our patient exhibited learning difficulties, slurred speech, and ataxia, though brain and pituitary MRI were reported as normal.\u003c/p\u003e\u003cp\u003eHypogonadism and Genitourinary Abnormalities get references\u003c/p\u003e\u003cp\u003eHypogonadism occurs in approximately 59% of cases [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e], presenting as delayed puberty, cryptorchidism, micropenis, or gonadal dysgenesis. Female patients may develop menstrual irregularities or polycystic ovaries [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Mujahid et al. reported hypogonadism in 19.5% of males, with pituitary anomalies uncommon [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. Our patient had reduced penile length, prepubertal descended testes, absent pubic hair, and low testosterone with hypogonadotropic hypogonadism as confirmed by low luteinizing and follicle stimulating hormones.\u003c/p\u003e\u003cp\u003eSecondary Features\u003c/p\u003e\u003cp\u003eSecondary features of BBS arise from ciliary dysfunction affecting multiple systems. In our patient, acanthosis nigricans and pigmentary dermatoses reflect insulin resistance; central hypothyroidism and low cortisol result from hypothalamic\u0026ndash;pituitary involvement; deranged liver enzymes reflect impaired bile duct development predisposing to hepatic dysfunction; and the high-arched palate stems from abnormal craniofacial morphogenesis [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e].\u003c/p\u003e\u003cp\u003eGenetic Findings\u003c/p\u003e\u003cp\u003eThe most common mutations occur in BBS1 and BBS10, each accounting for approximately 20% of cases [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e, \u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e], while TTC8 mutations are rare (~\u0026thinsp;2%) and may present with syndromic or isolated retinal degeneration [\u003cspan additionalcitationids=\"CR20\" citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. Genetic analysis in our patient confirmed a TTC8 mutation, thereby establishing the diagnosis.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis first case reported from a rural public hospital highlights the importance of early recognition of rare syndromes such as BBS. A high index of suspicion, particularly in patients presenting with retinitis pigmentosa and obesity, coupled with timely referral, enabled accurate diagnosis and genetic confirmation. Multidisciplinary management remains essential. Although prognosis is guarded, early identification can guide supportive interventions and genetic counselling. Greater awareness among healthcare workers is needed to facilitate prompt diagnosis and care.\u003c/p\u003e\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\u003ch2\u003eCase limitation\u003c/h2\u003e\u003cp\u003eThe patient was lost to follow-up before initiation of some planned interventions (e.g., puberty induction with testosterone, surgical excision of extra digits). This limited the ability to document treatment outcomes and long-term prognosis. While hypogonadism and central hypothyroidism were identified, adrenocorticotropic hormone (ACTH) was not tested due to financial constraints, which may have provided additional clarity on pituitary function. Some recommended tests such as electroretinography and formal neurocognitive assessment were not performed, which restricted full phenotypic characterization. Although a TTC8 mutation was identified in the patient, segregation analysis in other family members was not conducted. This could have provided stronger confirmation and insight into inheritance patterns. As an isolated case, findings cannot be generalized to all patients with BBS, particularly given genetic and phenotypic heterogeneity.\u003c/p\u003e\u003c/div\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthical Compliance:\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWritten consent was obtained from the mother, and assent was provided by the 14-year-old patient.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions:\u003c/strong\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAll three authors contributed to the clinical review, patient management, and manuscript preparation of this case report\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of Interest:\u003c/strong\u003e The authors declare no conflicts of interest.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo funding was received for this report.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData Availability\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eUse of Large Language Models, AI, and Machine Learning Tools:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;None declared.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eBeales PL, Warner AM, Hitman GA, Thakker R, Flinter FA. Bardet-Biedl syndrome: a molecular and phenotypic study of 18 families. J Med Genet. 1997;34(2):92\u0026ndash;8.\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMoore SJ, Green JS, Fan Y, et al. Clinical and genetic epidemiology of Bardet-Biedl syndrome in newfoundland: a 22-year prospective, population-based, cohort study. Am J Med Genet A. 2005;132A(4):352\u0026ndash;60.\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eHjortsh\u0026oslash;j TD, Gr\u0026oslash;nskov K, Br\u0026oslash;ndum-Nielsen K, Rosenberg T. 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Hum Mol Genet. 2004;13:R65\u0026ndash;71.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"orphanet-journal-of-rare-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ojrd","sideBox":"Learn more about [Orphanet Journal of Rare Diseases](http://ojrd.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ojrd/default.aspx","title":"Orphanet Journal of Rare Diseases","twitterHandle":"@bmc","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Bardet-Biedl, syndrome, ciliopathy, vision loss, retardation, obesity, delayed puberty, mutation","lastPublishedDoi":"10.21203/rs.3.rs-7493665/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7493665/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBardet-Biedl syndrome (BBS) is a rare inherited disorder of ciliopathy characterized by dysfunction of primary cilia resulting in a myriad of manifestations in various organ systems. These manifestations include progressive retinal dystrophy, central obesity, polydactyly, mental retardation, hypogonadism, and renal dysfunction. Additional manifestations include, but are not limited to, hypertension, diabetes mellitus, congenital heart disease, hepatic fibrosis, asthma and neurological features, illustrating the complexity of its clinical spectrum. The clinical features of BBS patients are widely shared with those of patients suffering from other ciliopathies, especially autosomal recessive syndromic disorders. Moreover, mutations in cilia-related genes can cause different ciliopathies. Herein, we report a case of a 14-year-old boy with progressive vision loss, mental retardation, delayed puberty as well as toe and finger abnormalities. Genetic tests confirmed Bardet-Biedl syndrome. The caregiver was offered genetic counselling and the boy was started on supportive management, including puberty induction.\u003c/p\u003e","manuscriptTitle":"Bardet-biedl Syndrome With Ttc8 Mutation in a Kenyan Adolescent: A Case Report From a Rural Public Hospital","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-09-23 17:34:35","doi":"10.21203/rs.3.rs-7493665/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2025-09-24T14:17:18+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2025-09-08T21:40:21+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-09-08T21:18:11+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-09-04T01:54:23+00:00","index":"","fulltext":""},{"type":"submitted","content":"Orphanet Journal of Rare Diseases","date":"2025-09-01T23:30:21+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"orphanet-journal-of-rare-diseases","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ojrd","sideBox":"Learn more about [Orphanet Journal of Rare Diseases](http://ojrd.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ojrd/default.aspx","title":"Orphanet Journal of Rare Diseases","twitterHandle":"@bmc","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0b90feff-124c-4d9e-b32f-8eeb66a192c3","owner":[],"postedDate":"September 23rd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2025-10-06T04:03:53+00:00","versionOfRecord":[],"versionCreatedAt":"2025-09-23 17:34:35","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7493665","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7493665","identity":"rs-7493665","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}