Ремоделирование миометрия при соединительнотканной дисплазии у женщин со слабостью родовой деятельности

The aim of the study was to identify morphological features of the myometrium of the lower segment of the uterus during connective tissue dysplasia (CTD) in women with uterine inertia. Materials and methods: we conducted histological, immunohistochemical (antibodies to collagen I, III, matrix metalloproteinases MMP-1, MMP-9, inhibitor of matrix metalloproteinases TIMP-1, fibronectin; fibulin-5; connexin-43), electron microscopy and immunocytochemical study with morphometry of 15 fragments of the myometrium of pregnant women with diabetes with weakness of labor activity (the main group) and 10 without diabetes (control group). The results of the study: in the myometrium in CTD, there is a decrease in the expression of connexin-43, fibulin-5, TIMP-1, collagen I and III types with a predominance of type III collagen, and the expression level of fibronectin and MMP1,9 is not changed. Electron microscopy and immunocytochemistry have shown a decrease in the number of intercellular contacts and a sharp decrease in the expression of connexin-43 compared to control. Conclusions: the complex of the detected changes of the myometrium in women with uterine inertia is a manifestation of CTD.