Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study

Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study Shoumei Zang, Meiqin Chen, Huijie Huang, Xinli Zhu, Danfang Yan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-33712/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 01 Jan, 2021 Read the published version in Quantitative Imaging in Medicine and Surgery → Version 1 posted You are reading this latest preprint version Abstract Background Salivary gland cancer (SGC) is comparatively rare and constitutes a variety of histological subtypes. Previously published studies included SGC patients who were irradiated using conventional radiotherapy or 3-dimensional conformal radiotherapy (3-DCRT) may have led to suboptimal oncological outcomes. Methods We identified 60 patients with major SGC treated with surgery followed by postoperative intensity-modulated radiotherapy (IMRT). Data for overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), prognostic factors, and treatment-related toxicities were analyzed. Survival was analyzed using the Kaplan–Meier method and compared using the log-rank test. Results Adenoid cystic carcinoma (ACC) was the most common histology ( n = 21; 35%). With a median follow-up of 55.5 months, OS and PFS were 90.7%, 85.1%, and 85.1%; and 80.1%, 72.7%, and 63.1%, at 3, 5, and 10 years, respectively. LRRFS and DMFS at 3, 5, and 10 years were 87.4%, 82.1%, and 82.1%; and 85.3%, 78.4%, and 66.1%, respectively. Five-year OS, PFS, LRRFS, and DMFS for ACC was 100%, 67.7%, 76.2%, and 90.2%, respectively. In multivariable analysis (MVA), N stage was an independent predictor of PFS ( p = 0.047). Positive margin was a significant prognostic factor for PFS, LRRFS, and DMFS ( p = 0.036, 0.026, and 0.011, respectively). Major nerve involvement was significantly correlated with PFS and DMFS ( p = 0.034 and 0.008, respectively). Interval from surgery to radiotherapy (RT) predicted PFS and DMFS ( p = 0.036 and 0.012, respectively). The most common acute toxicities were mucositis and dermatitis, and xerostomia was the most common late adverse event. Lung metastasis was the most common pattern of distant failure. Conclusion Postoperative IMRT leads to improved survival for SGC patients with acceptable toxicities. Cancer Biology Oncology salivary gland cancer IMRT survival Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Background Salivary gland cancer (SGC) constitutes a heterogeneous group of diseases, accounting for only 3–6% of all head and neck cancer [1]. Although its etiology remains unclear, SGC prognosis has improved thanks to combined treaments of surgery, postoperative radiotherapy (PORT) and chemotherapy. Retrospective reviews have shown that prognosis for SGC patients depends on SGC histology, grade, and stage [2–4]. Other characteristics affecting prognosis include positive margin, extracapsular extension, bone and perineural invasions [1]. However, it is difficult to compare studies owing to differences in the number of patients enrolled in each study, pathological types, and treatment strategies. Intensity-modulated radiotherapy (IMRT) has led to increased treatment accuracy and the possibility of delivering higher doses to the tumor region. This suggests that previous studies that included patients who were irradiated using conventional radiotherapy (RT) or 3-dimensional conformal radiotherapy (3-DCRT) may have yielded lower locoregional control rates. We focused on postoperative IMRT, which was developed to improve local tumor control rate and quality of life and has been widely adopted for the treatment of head and neck cancer in recent decades. Because of the differences in biological behavior between major and minor SGC, prognosis varies considerably. Here, we collected and analyzed comprehensive treatment outcomes for major SGC patients treated with surgery and postoperative IMRT, and explored survival, related adverse prognostic factors, treatment failure patterns, and adverse events. Methods Patients We retrospectively reviewed 60 patients with histologically confirmed primary SGC treated at the First Affiliated Hospital of Zhejiang University from January 2009 to December 2016. All the patients had newly diagnosed diseases and received upfront surgery followed by external beam RT using IMRT. Patients with recurrent or metastatic disease or those who failed to finish the scheduled RT were excluded. Evaluation All patients were initially evaluated by a multimodality treatment team consisting of an otolaryngologist, a medical oncologist, and a RT oncologist. All patients underwent a detailed physical examination. Histological confirmation of SGC was required before treatment. Axial imaging with computed tomography (CT) was a routine part of patient evaluation, and most patients had also undergone either magnetic resonance imaging (MRI) or positron emission tomography (PET). Histological diagnosis was confirmed according to the WHO histologic subtype criteria for SGC [5]. All patients were restaged based on the 2018 American Joint Committee on Cancer classification. Acute adverse events were graded according to electronic records. Late toxicity was assessed based on follow-up visits. Treatment All patients underwent initial primary resection, with neck dissection (ND) therapeutically (if clinically positive lymph node; cN+) or electively in high-risk cN0 (clinically negative lymph node) patients. For IMRT, patients were immobilized in the supine position with a thermoplastic head–neck or head–neck–shoulder mask to ensure the daily reproducibility of treatments. Simulation CT scan was performed with 3-mm slice thickness and transported to the treatment planning system. Clinical target volume (CTV) was defined as postoperative tumor bed and the elective nodal area (Figure 1). Elective nodal irradiation target volume comprised the positive lymph nodal areas plus at least one level beyond. Organ-at-risk volumes (spinal cord, optic apparatus, mandible) were delineated on each slice. The maximal dose constraints were below 45 Gy for the spinal cord, 55 Gy for the optic apparatus, and 70 Gy for the mandible. For the planning target volume (PTV), a 0.3-cm margin was applied to the CTV considering daily setup error. The prescribed dose was 60–68 Gy, administered at a daily 2 Gy/fraction, 5 days/week over 6–6.8 weeks (30–34 fractions). Figure 1 Chemotherapy was administered to patients with advanced disease or in the presence of high pathological risk factors. Cisplatin (80 mg/m 2 intravenously every 3 weeks) was the most commonly used concomitant chemotherapy schedule. Several patients received adjuvant chemotherapy of cisplatin (80 mg/m 2 intravenously, day 1) and 5-FU (1000 mg/m 2 continuous infusion over 120 h), or cisplatin (80 mg/m 2 intravenously, day 1) and capecitabine (1250 mg/m 2 orally twice a day, day 1 to day 14) repeated every 3 weeks followed by PORT. Follow-up After treatment completion, patients were evaluated every 3 months for the first 1 year, every 3-6 months over the following 4 years, and yearly thereafter. At each follow-up visit, a physical examination and imaging were performed, including fiberoptic endoscopy if indicated. A PET scan was performed if recurrence or metastasis was suspected. Overall survival (OS) was defined as the time from surgery to the date of death; progression-free survival (PFS) as the time from surgery to the date of local or regional recurrence, distant metastases, or death from any cause; locoregional relapse-free survival (LRRFS) as absence of disease recurrence in the local site or regional lymph node; and distant metastasis-free survival (DMFS) as the time to distant metastasis. Statistical analysis Survival was analyzed using the Kaplan–Meier method and compared using the log-rank test. A Cox proportional hazards regression model was used for multivariable analysis (MVA). p <0.05 was considered significant. Statistical tests were two-sided. All data were analyzed using SPSS 20.0. Results Clinicopathological characteristics Patient characteristics are summarized in Table 1. The median follow-up was 55.5 months (range 1–114 months). Median age at initial diagnosis was 52 years (range 15–76 years). Among the patients, 35 (58.3%) were male and 25 (41.7%) female. Median tumor size was 2.5 cm (range 1–15 cm). Most patients presented with a palpable mass at initial presentation. Twenty-three (38.3%) experienced pain and 5 (8.3%) showed facial nerve paralysis. In some patients, painless masses had remained stable for several years and then began to grow rapidly. Histologic types included ACC in 21 patients (35%), lymphoepithelial carcinoma (LELC) in 12 (20%), mucoepidermoid carcinoma (MEC) in 8 (13.3%), salivary duct carcinoma (SDC) in 5 (8.3%), squamous cell carcinoma (SCC) in 4 (6.7%), basal cell adenocarcinoma (BCAC) in 3 (5%), myoepithelial carcinoma in 2 (3.3%), acinic cell carcinoma (AcCC) in 1 (1.7%), and others in 4 (6.7%). The primary sites were the parotid gland in 34 patients (56.7%), submandibular gland in 17 (28.3%), and sublingual gland in 9 (15%). The T stage distribution was 14 (23.3%) T1–T2 and 46 (76.7%) T3–T4b. The N stage distribution was 41 (68.3%) N0, 8 (13.3%) N1, 8 (13.3%) N2b, and 3 (5%) N2c. Eleven (18.3%) presented with stage Ⅰ–Ⅱ disease and 49 (81.7%) with stage Ⅲ–Ⅳb. Skin involvement was observed in 5 patients (8.3%), positive margin in 7 (11.7%), extra-parenchymal extension in 34 (56.7%), perineural invasion in 19 (31.7%), and major nerve involvement in 28 (46.7%). Treatment characteristics All patients received primary tumor resection with curative intention; 42 (70%) received concurrent ND, 19 of which (31.7%) had pathologic evidence of N+. The median interval from surgery to RT was 30 days. The median dose to the tumor bed was 63 Gy (range 60–68 Gy). Four patients (6.7%) received tumor bed irradiation only. Forty-nine (81.7%) were treated with tumor bed and unilateral neck nodal irradiation, while the rest received tumor bed and bilateral neck nodal irradiation. Four patients received concurrent three-weekly cisplatin chemotherapy. Two received adjuvant chemotherapy after PORT, one with cisplatin and 5-FU and the other with cisplatin and capecitabine. Of the 4 patients who received chemotherapy, 2 exhibited advanced nodal stage (N2b) and 2 major nerve involvement; all presented with stage T3–T4 disease. Table 1 Survival Kaplan–Meier curves for OS, PFS, LRRFS, and DMFS are shown in Figure 2. The 3-, 5-, and 10-year OS was 90.7%, 85.1%, and 85.1%, while that for PFS was 80.1%,72.7%, and 63.1%, respectively. The 3-, 5-, and 10-year LRRFS was 87.4%, 82.1%, and 82.1%, while that for DMFS was 85.3%, 78.4%, and 66.1%, respectively. Figure 2 Prognostic factors for OS Risk factors for survival are summarized in Table 2&Additional file 1. Univariable analysis (UVA) suggested that a higher N stage was associated with decreased survival, with patients having stage N0 disease surviving significantly longer than those with stages N1, N2b, and N2c ( p =0.025). Primary site was a prognostic factor for OS, with 5-year OS rates of 90%, 67.6%, and 100% for parotid, submandibular, and sublingual gland tumors ( p =0.039). However, no significant association was found between OS and N stage or primary site in MVA. Prognostic factors for PFS Based on our log-rank test, gender was strongly associated with PFS ( p =0.018), although it did not reach significance as a predictor in MVA. For patients with and without major nerve involvement, the 5-year PFS was 85% and 59.5% ( p =0.019), respectively. Notably, when interval from surgery to RT was analyzed as a categorical variable using the median interval of 30 days as a cutpoint, a significant difference in PFS was observed ( p =0.044). No significant difference in PFS was observed among patients with N stage and positive margin in UVA ( p =0.164, 0.092). MVA indicated that major nerve involvement (hazard ratio [HR]=2.394, 95% confidence interval [CI]=0.664–8.89, p =0.034), N stage (HR=0.089, 95% CI=0.008–0.964, p =0.047), positive margin (HR=4.086, 95% CI=1.097–15.219, p =0.036), and interval from surgery to RT (HR=3.934, 95% CI=1.097–14.105, p =0.036) were significant independent predictors of PFS (Figure 3). Table 2 Additional file 1 Figure 3 Prognostic factors for LRRFS In UVA, the 5-year LRRFS for patients with positive margin was 57.1%, compared with 85.9% for those with negative margin ( p =0.029). In MVA, positive margin was an independent predictor for LRRFS (HR=5.064, 95% CI=1.211–21.187, p =0.026) (Figure 4). Prognostic factors for DMFS Major nerve involvement, N stage, and clinical stage were prognostic factors for poor DMFS in UVA ( p =0.024, 0.014, and 0.049, respectively). When a Cox proportional hazards regression model was used to predict distant metastases, major nerve involvement (HR=2.115, 95% CI=0.521–8.583, p =0.008), positive margin (HR=6.367, 95% CI=1.524–26.603, p =0.011), and interval from surgery to RT (HR=6.231, 95% CI=1.503–25.829, p =0.012) were identified as independent predictors of distant metastases (Figure 4). Figure 4 In ACC subgroup analysis, 5-year OS, PFS, LRRFS, and DMFS were 100%, 67.7%, 76.2%, and 90.2%, respectively. In UVA, perineural invasion was significantly associated with PFS and DMFS ( p =0.021 and 0.026, respectively); major nerve involvement was was strongly associated with PFS ( p =0.014); parotid gland and N stage were associated with poor LRRFS ( p =0.041 and 0.023, respectively); and positive margin was an important prognostic factor for PFS, LRRFS, and DMFS ( p =0.021, 0.002, and 0.021, respectively). However, there were too few ACCs to allow for MVA. For detailed information see Table 3. Adverse events The most acute adverse events were grade Ⅱ/Ⅲ mucositis ( n =44, 73.3%) and gradeⅠ/Ⅱ dermatitis ( n =46, 76.7%). Xerostomia was the most common late adverse event ( n =18, 30%), followed by hearing impairment ( n =17, 28.4%), taste abnormalities ( n =15, 25%), paresthesia ( n =14, 23.3%), fibrosis of the skin ( n =11, 18.3%), trismus ( n =6, 10%), and osteoradionecrosis ( n =2, 3.3%). No grade 4 acute or late adverse events were observed. Patterns of failure Treatment failure occurred in 16 (26.7%) of the 60 patients (Figure 5). Locoregional recurrence occurred in 9 (15%), local failure in 8 (13.3%), and regional failure in 3 (5%). Distant metastasis occurred in 14 patients (23.3%). In the 7 patients with distance-related failure, metastasis was accompanied by locoregional recurrence. The median time to distant metastasis was 49.5 months. Distant metastasis occurred in the lung ( n =10, 16.7%), bones ( n =3, 5%), brain ( n =1, 1.7%), elsewhere ( n =1, 1.7%), and at multiple sites ( n =2, 3.3%). Discussion This retrospective study focused on the clinical outcomes, prognostic factors, failure patterns, and adverse events in patients with major SGC treated with surgery and postoperative IMRT. Similar to that reported in the literature [3,6,7], our study showed that ACC was the most common histology, followed by LELC. As histology is an important prognostic factor, for SDC, adenocarcinoma and undifferentiated carcinoma have worse prognosis [8,9], we performed an ACC subgroup analysis. Our clinical cohort exhibited excellent clinical outcomes that compared very favorably with those reported in the literature [10]. Our MVA showed that N stage, positive margin, major nerve involvement, and interval from surgery to RT were unfavorable prognostic factors. With regard to the relationship between clinicopathologic parameters and OS, there was no negative prognostic factor for survival in MVA. Probable reason was excellent survival of our patients. Although positive margin and N stage were not prognostic factors for PFS in the UVA, and neither was N stage for LRRFS, we nevertheless included them in the Cox proportional hazards regression model as positive margin and positive lymph nodes were previously shown to be important predictive factors for SGC [3,11–13]. After adjusting for factors that might affect prognosis, N stage and positive margin were found to be independent prognostic factors for PFS, although N stage was not a predictive factor for LRRFS. Positive margin was also an independent prognostic factor for LRRFS and DMFS, suggesting that margin status information should be included in clinical pathology reports. Major nerve involvement was an independent prognostic factor for poor PFS and DMFS, while a time from surgery to RT >30 days resulted in worse PFS and DMFS. Combination treatment modalities are usually required for SGC. Surgical resection followed by PORT is practical and effective at increasing survival and locoregional control rates in patients with a tumor size ≥4 cm, deep lobe settlement, high grade, positive margin, local advanced stage, lymph node metastasis, soft tissue or bone infiltration, and perivascular and perineural invasion [14–17]. Terhaard et al. revealed that the 5- and 10-year actuarial local control rates were significantly higher for PORT vs surgery alone (94% vs 84% and 91% vs 76%, respectively) ( p =0.0005) [18]. A comparison of our outcomes with those of other institutions is difficult because of different case mix and wide variety of histological subtypes involved. Overall, the outcomes in our study are better than those reported for historical data of other institutions using PORT use for SGC treatment (5-year OS: 85.1% vs 61%–74%; 10-year OS: 85.1% vs 48%–71%) [15,16,19–21]. The better survival rates in this series could be explained by a “cohort effect” resulting from improved diagnostic capabilities and treatment modalities. Previous studies have involved conventional RT or 3-DCRT treatment; however, all the patients in this study received IMRT. Compared with conventional RT or 3-DCRT, IMRT permits a greater precision and modulation of the RT beam to keep high doses away from vital structures. This offers improved locoregional control in SGC patients, which corresponds to better OS [22,23]. Furthermore, because a greater amount of normal tissue is spared, IMRT is less toxic, resulting in a smaller impact on quality of life [24]. Our patients exhibited a reduced incidence of xerostomia (30%) compared with those from historical studies (83%) [25]. In agreement with the published literature [26,27], distant metastasis was the predominant mode of failure, highlighting the need for effective systemic therapies. Chemotherapy is generally reserved for the palliative treatment of symptomatic locally recurrent or metastatic disease, and has a limited effect [28]. Recent studies have also indicated that postoperative chemoradiotherapy (POCRT) promotes higher survival and locoregional control than PORT treatment alone [29–32]. However, no significant differences in DMFS, disease-free survival, and OS were observed when adding concurrent chemotherapy to PORT, while POCRT has been associated with increased mortality and toxicity [31,33]. We could not evaluate the effect of POCRT on outcomes owing to the small number of patients who received chemotherapy. Our study had several significant limitations. The small sample size did permit an evaluation of outcome stratified by various histological subtypes. Additionally, our median follow-up was approximately 55.5 months, and median OS, PFS, LRRFS, and DMFS were not reached. Lastly, The pathological detection of SGC margin status and perineural invasion may vary greatly depending on the extent of sampling. Nevertheless, our observations have potential for use in the design of prospective SGC clinical trials. Conclusion Our series of 60 SGC patients showed that postoperative IMRT leds to improved OS for SGC with acceptable toxicities. N stage, positive margin, major nerve involvement and interval from surgery to RT were important factors that were associated with oncological outcomes. Abbreviations SGC: salivary gland cancer; 3-DCRT: 3-dimensional conformal radiotherapy; IMRT: intensity-modulated radiotherapy; OS: overall survival; PFS: progression-free survival; LRRFS: locoregional relapse-free survival; DMFS: distant metastasis-free survival; ACC: adenoid cystic carcinoma; MVA: multivariable analysis; RT: radiotherapy; PORT: postoperative radiotherapy; CT: computed tomography; MRI: magnetic resonance imaging; PET: positron emission tomography; ND: neck dissection; CTV: Clinical target volume; PTV: planning target volume; MEC: mucoepidermoid carcinoma; LELC: lymphoepithelioid carcinoma; SDC: salivary duct carcinoma; SCC: squamous cell carcinoma; BCAC: basal cell adenocarcinoma; AcCC: acinic cell carcinoma; UVA: Univariable analysis; POCRT: postoperative chemoradiotherapy Declarations Ethics approval and consent to participate The study was approved by the Institutional Review Board of the First Affiliated Hospital, Zhejiang University. And written informed consents were obtained. Consent for publication Not applicable. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Conflicts of interest There are no conflicts to declare. Funding This study was independent research funded by the Department of Health of Zhejiang Province (2018265493, 2017197137). The fund had no role in study design, or data analysis. Authors ’ contributions SZ: Collection and analysis of data, manuscript writing; MC: Collection and analysis of data; XZ & HH: Collect and contribution of data, supervision; DF and SY: Conceptual design, supervision, critical revision of intellectual contents. All authors read and approved the final manuscript. Acknowledgments Not applicable. References [1] Ata-Ali J, Zurriaga O, Alberich C. Incidence and survival rates for malignant salivary gland tumors. J Oral Sci 2016;58:67–73. [2] Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986;8:177–84. [3] Terhaard CH, Lubsen H, Van der Tweel I, Hilgers FJ, Eijkenboom WM, Marres HA, et al. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 2004;26:681–92; discussion 692–3. [4] Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, et al. Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg 2005;133:702–8. [5] Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 2006;85:74 [6] Bell RB, Dierks EJ, Homer L, Potter BE. Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg 2005;63:917–28. [7] Kaur J, Goyal S, Muzumder S, Bhasker S, Mohanti BK, Rath GK. Outcome of surgery and post-operative radiotherapy for major salivary gland carcinoma: ten year experience from a single institute. Asian Pac J Cancer Prev 2014;15:8259–63. [8] Wahlberg P, Anderson H, Biorklund A, Moller T, Perfekt R. Carcinoma of the parotid and submandibular glands--a study of survival in 2465 patients. Oral Oncol 2002;38:706–13. [9] Jang JY, Choi N, Ko YH, Chung MK, Son YI, Baek CH, et al. Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer 2018;18:672. [10] Ali S, Palmer FL, Katabi N, Lee N, Shah JP, Patel SG, et al. Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation. Laryngoscope 2017;127:2265–9. [11] Qian K, Di L, Guo K, Zheng X, Ji Q, Wang Z. Cervical Lymph Node Metastatic Status and Adjuvant Therapy Predict the Prognosis of Salivary Duct Carcinoma. J Oral Maxillofac Surg 2018;76:1578–86. [12] Yoo SH, Roh JL, Kim SO, Cho KJ, Choi SH, Nam SY, et al. Patterns and treatment of neck metastases in patients with salivary gland cancers. J Surg Oncol 2015;111:1000–6. [13] Johnston ML, Huang SH, Waldron JN, Atenafu EG, Chan K, Cummings BJ, et al. Salivary duct carcinoma: Treatment, outcomes, and patterns of failure. Head Neck 2016;38 Suppl 1:E820–6. [14] Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, et al. A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network). Crit Rev Oncol Hematol 2014;91:142–58. [15] Storey MR, Garden AS, Morrison WH, Eicher SA, Schechter NR, Ang KK. Postoperative radiotherapy for malignant tumors of the submandibular gland. Int J Radiat Oncol Biol Phys 2001;51:952–8. [16] North CA, Lee DJ, Piantadosi S, Zahurak M, Johns ME. Carcinoma of the major salivary glands treated by surgery or surgery plus postoperative radiotherapy. Int J Radiat Oncol Biol Phys 1990;18:1319–26. [17] Pohar S, Gay H, Rosenbaum P, Klish D, Bogart J, Sagerman R, et al. Malignant parotid tumors: presentation, clinical/pathologic prognostic factors, and treatment outcomes. Int J Radiat Oncol Biol Phys 2005;61:112–8. [18] Terhaard CH, Lubsen H, Rasch CR, Levendag PC, Kaanders HH, Tjho-Heslinga RE, et al. The role of radiotherapy in the treatment of malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 2005;61:103–11. [19] Toonkel LM, Guha S, Foster P, Dembrow V. Radiotherapy for parotid cancer. Ann Surg Oncol 1994;1:468–72. [20] Fitzpatrick PJ, Theriault C. Malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 1986;12:1743–7. [21] Bhide SA, Miah A, Barbachano Y, Harrington KJ, Newbold K, Nutting CM. Radical radiotherapy for treatment of malignant parotid tumours: a single centre experience. 1995–2005. Br J Oral Maxillofac Surg 2009;47:284–9. [22] Chen JL, Huang YS, Kuo SH, Hong RL, Ko JY, Lou PJ, et al. Intensity-modulated radiation therapy achieves better local control compared to three-dimensional conformal radiation therapy for T4-stage nasopharyngeal carcinoma. Oncotarget 2017;8:14068–77. [23] Hosni A, Huang SH, Goldstein D, Xu W, Chan B, Hansen A, et al. Outcomes and prognostic factors for major salivary gland carcinoma following postoperative radiotherapy. Oral Oncol 2016;54:75–80. [24] van der Veen J, Nuyts S. Can Intensity-Modulated-Radiotherapy Reduce Toxicity in Head and Neck Squamous Cell Carcinoma? Cancers. 2017;9(10). pii: E135. [25] Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 2011;12:127–36. [26] Samant S, van den Brekel MW, Kies MS, Wan J, Robbins KT, Rosenthal DI, et al. Concurrent chemoradiation for adenoid cystic carcinoma of the head and neck. Head Neck 2012;34:1263–8. [27] Hosal AS, Fan C, Barnes L, Myers EN. Salivary duct carcinoma. Otolaryngol Head Neck Surg 2003;129:720–5. [28] Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Keus RB, Hart AA. Stage as major long term outcome predictor in minor salivary gland carcinoma. Cancer 2000;89:1195–204. [29] Tanvetyanon T, Qin D, Padhya T, McCaffrey J, Zhu W, Boulware D, et al. Outcomes of postoperative concurrent chemoradiotherapy for locally advanced major salivary gland carcinoma. Arch Otolaryngol Head Neck Surg 2009;135:687–92. [30] Maruya S, Namba A, Matsubara A, Kakehata S, Takeda I, Shirasaki T, et al. Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel. Int J Clin Oncol 2006;11:403–6. [31] Hsieh CE, Lin CY, Lee LY, Yang LY, Wang CC, Wang HM, et al. Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study. Radiat Oncol 2016;11:47. [32] Schoenfeld JD, Sher DJ, Norris CM, Jr., Haddad RI, Posner MR, Balboni TA, et al. Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy. Int J Radiat Oncol Biol Phys 2012;82:308–14. [33] Tanvetyanon T, Fisher K, Caudell J, Otto K, Padhya T, Trotti A. Adjuvant chemoradiotherapy versus with radiotherapy alone for locally advanced salivary gland carcinoma among older patients. Head Neck 2016;38:863–70. Tables Table 1 . Characteristics of the 60 SGC patients Characteristics outcome (%) Characteristics outcome (%) Median age (yr) 52 Clinical stage Gender Ⅰ - Ⅱ 11 (18.3%) Male 35 (58.3%) Ⅲ - Ⅳ b 49 (81.7%) Female 25 (41.7%) Skin involvement Primary site Yes 5 (8.3%) Parotid gland 34 (56.7%) No 55 (91.7%) Submandibular gland 17 (28.3%) Margin Sublingual gland 9 (15%) Positive 7(11.7%) Median size of tumor (cm) 2.5 Negative 53 (88.3%) Pain Extra-parenchymal extension Yes 23 (38.3%) Yes 34 (56.7%) No 37 (61.7%) No 26 (43.3%) Facial nerve paralysis Perineural invasion Yes 5 (8.3%) Yes 19 (31.7%) No 55 (91.7%) No 41 (68.3%) Histologic types Major nerve involvement ACC 21 (35%) Positive 28 (46.7%) LELC 12 (20%) Negative 32 (53.3%) MEC 8 (13.3%) Surgery SDC 5 (8.3%) Primary tumor resection 18 (30%) SCC 4 (6.7%) Primary tumor resection + ND 42 (70%) BCAC 3 (5.0%) Interval from surgery to RT (d) Myoepithelial carcinoma 2 (3.3%) ≤ 30 30 (50%) AcCC 1 (1.7%) ＞ 30 30 (50%) Others 4 (6.7%) Radiotherapy Table 1 . Characteristics of the 60 SGC patients(Continued) Characteristics outcome (%) Characteristics outcome (%) T stage Tumor bed 4 (6.7%) T1-T2 14 (23.3%) Tumor bed+unilateral neck 49 (81.7%) T3-T4b 46 (76.7%) Tumor bed+bilateral neck 7 (11.6%) N stage Median dose （ Gy ） 63 N0 41 (68.3%) Chemoradiotherapy N1 8 (13.3%) Yes 4 (6.7%) N2b 8 (13.3%) No 56 (93.3%) N2c 3 (5%) ACC, adenoid cystic carcinoma; MEC, mucoepidermoid carcinoma; LELC, lymphoepithelioid carcinoma; SDC, salivary duct carcinoma; SCC, squamous cell carcinoma; BCAC, basal cell adenocarcinoma; AcCC, acinic cell carcinoma; RT, radiotherapy; ND, neck dissection. Table 2 . Univariable analysis (UVA) and multivariable analysis (MVA) for overall survival (OS) and progression-free survival (PFS) Variables Number OS PFS at 5y(%) UVA MVA at 5y(%) UVA MVA p HR 95%CI P p HR 95%CI P Gender 0.989 0.018 Male 35 84.9 62.1 Female 25 85.2 87.1 Age(y) 0.228 0.172 ≤52 31 90.8 77.4 ＞ 52 29 80.2 66.7 Perineural invasion 0.373 0.951 No 41 84.1 71.8 Yes 19 94.1 77.0 Major never involvement 0.665 0.019 2.394 0.664-8.896 0.034 Negative 32 82.8 85.0 Positive 28 86.9 59.5 Extra-parenchymal extension 0.268 0.581 No 26 95.0 71.2 Yes 34 82.5 74.9 Primary site 0.039 0.641 Parotid gland 34 90.0 70.0 Submandibular gland 17 67.6 64.7 Sublingual gland 9 100.0 88.9 Table 2 . Univariable analysis (UVA) and multivariable analysis (MVA) for overall survival (OS) and progression-free survival (PFS) (Continued) Variables Number OS PFS at 5y(%) UVA MVA at 5y(%) UVA MVA p HR 95%CI P p HR 95%CI P T stage 0.154 0.244 T1-T2 14 100.0 79.1 T3-T4b 46 81.1 71.0 N stage 0.025 0.164 0.089 0.008-0.964 0.047 N0 41 91.5 78.2 N1 8 - - N2b 8 43.8 60.0 N2c 3 - - Clinical stage 0.188 0.141 Ⅰ - Ⅱ 11 100.0 85.7 Ⅲ - Ⅳ b 49 81.6 70.5 Margin 0.206 0.092 4.086 1.097-15.219 0.036 Positive 53 88.4 74.9 Negative 7 64.3 57.1 Skin involvement 0.550 0.458 No 55 85.7 75.3 Yes 5 80.0 40.0 Interval from surgery to RT (d) 0.635 0.044 3.934 1.097-14.105 0.036 ≤ 30 30 84.7 85.2 ＞ 30 30 84.4 59.6 Table 3 . Univariable analysis (UVA) of prognostic factors for adenoid cystic carcinoma (ACC) Variables Number PFS LRRFS DMFS at 5y（%） UAV p at 5y (%) UAV p at 5y (%) UAV p Perineural invasion 0.021 0.026 No 15 75 - 100 Yes 6 - - - Major nerve involvement 0.014 Negative 13 100 - - Positive 8 - - - Margin 0.021 0.002 0.021 Negative 19 70.8 80 94.4 Positive 2 - - - Primary site 0.041 Parotid gland 14 - 66.7 - Submandibular gland 4 - 100 - Sublingual gland 3 - - - N stage 0.023 N0 12 - 80 - N1 4 - - - N2b 3 - - - N2c 2 - - - Supplementary Files Additionalfile1.docx Cite Share Download PDF Status: Published Journal Publication published 01 Jan, 2021 Read the published version in Quantitative Imaging in Medicine and Surgery → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-33712","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":648757,"identity":"1dfa1dce-1759-4089-9d0a-019361c7b983","order_by":0,"name":"Shoumei Zang","email":"","orcid":"","institution":"Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shoumei","middleName":"","lastName":"Zang","suffix":""},{"id":648758,"identity":"da385ce1-788b-4ee1-9fe6-dab90418c815","order_by":1,"name":"Meiqin Chen","email":"","orcid":"","institution":"Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Meiqin","middleName":"","lastName":"Chen","suffix":""},{"id":648759,"identity":"7ea8e0ff-f045-4c34-aeb7-1ff1fd1fc7f0","order_by":2,"name":"Huijie Huang","email":"","orcid":"","institution":"YiLi Friendship Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Huijie","middleName":"","lastName":"Huang","suffix":""},{"id":648760,"identity":"2a607a37-2352-4da8-9824-71088b38228a","order_by":3,"name":"Xinli Zhu","email":"","orcid":"","institution":"Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xinli","middleName":"","lastName":"Zhu","suffix":""},{"id":648761,"identity":"c119659f-8f30-4e79-9139-418ecf318c05","order_by":4,"name":"Danfang Yan","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4UlEQVRIiWNgGAWjYDCCAwwMH4AUDxsz88EHCRU1RGlhnAGkZPjY2ZINHpw5RrwWGzl+HjXJhy3MhHXwHT97sOHnjlqgw3jYKhIb2Bj427sT8GqRPJOX2Nh75jhQC++xG4k7ZBgkzpzdgFeLwYEc8we8bceAWvjSbiSeYWMwkMgloOX8G8PGv2AtPGYFiW3MRGi5kWPYzNtWA9bCQJQWyRtvDJtl2w4AtbAlSyScOcZD0C9853MMG9+21dnL9x8++PFHRY0cf3svfi1QcBjO4iFGOQjUEatwFIyCUTAKRiIAAIriSYo/I0CvAAAAAElFTkSuQmCC","orcid":"","institution":"Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Danfang","middleName":"","lastName":"Yan","suffix":""},{"id":648762,"identity":"cbfd2f74-b000-42aa-817c-9281cf77b678","order_by":5,"name":"senxiang yan","email":"","orcid":"https://orcid.org/0000-0002-4177-3048","institution":"Zhejiang University School of Medicine First Affiliated Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"senxiang","middleName":"","lastName":"yan","suffix":""}],"badges":[],"createdAt":"2020-06-05 14:49:02","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-33712/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-33712/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.21037/qims-21-836","type":"published","date":"2021-01-01T10:08:42+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":1299456,"identity":"ad822596-7a59-43c7-ae6c-f1d45ea56fdb","added_by":"auto","created_at":"2020-06-10 17:17:00","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":50443,"visible":true,"origin":"","legend":"A typical case of right parotid gland tumor (a) Axial T2-weighted magnetic resonance imaging (MRI) (b) Isodose line of treatment plans of intensity modulated radiotherapy (IMRT)","description":"","filename":"Fig1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/Fig1.jpg"},{"id":1299457,"identity":"af672fc3-205a-411e-9736-b7c6c28f54e4","added_by":"auto","created_at":"2020-06-10 17:17:00","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":44218,"visible":true,"origin":"","legend":"Kaplan-Meier curves of overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS)","description":"","filename":"Fig2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/Fig2.jpg"},{"id":1299458,"identity":"d70fe0a6-c1e3-418f-90a2-04875159da6d","added_by":"auto","created_at":"2020-06-10 17:17:01","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":68556,"visible":true,"origin":"","legend":"Comparison of survival according to clinicopathologic factors. (a) N stage (p=0.047); (b) margin (p=0.036); (c) major nerve involvement (p=0.034), (d) interval from surgery to RT (p=0.036)","description":"","filename":"Fig3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/Fig3.jpg"},{"id":1299459,"identity":"094b95ba-9e30-49b3-88ad-dbbb429d5eb7","added_by":"auto","created_at":"2020-06-10 17:17:01","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":65334,"visible":true,"origin":"","legend":"Comparison of survival according to clinicopathologic factors. (a) margin (p=0.026); (b) major nerve involvement (p=0.008); (c) margin (p=0.011); (d) interval from surgery to RT (p=0.012)","description":"","filename":"Fig4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/Fig4.jpg"},{"id":1299460,"identity":"acc077b3-661d-47a8-bd6c-b8b43eff0924","added_by":"auto","created_at":"2020-06-10 17:17:01","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":27253,"visible":true,"origin":"","legend":"Venn diagram of patterns of failure (16/60 patients)","description":"","filename":"Fig5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/Fig5.jpg"},{"id":19189378,"identity":"6d914f65-0229-433c-8317-cb58edb7d35c","added_by":"auto","created_at":"2022-03-14 10:08:50","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":530920,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/72dce238-abc3-453b-9c82-38b149b94ef4.pdf"},{"id":1499706,"identity":"02cc05a8-6234-4673-af83-cf98ddf6b300","added_by":"auto","created_at":"2020-07-06 18:12:08","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":17636,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile1.docx","url":"https://assets-eu.researchsquare.com/files/rs-33712/v1/Additionalfile1.docx"}],"financialInterests":"","formattedTitle":"Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study","fulltext":[{"header":"Background","content":"\u003cp\u003eSalivary gland cancer (SGC) constitutes a heterogeneous group of diseases, accounting for only 3\u0026ndash;6% of all head and neck cancer [1]. Although its etiology remains unclear, SGC prognosis has improved thanks to combined treaments of surgery, postoperative radiotherapy (PORT) and chemotherapy. Retrospective reviews have shown that prognosis for SGC patients depends on SGC histology, grade, and stage [2\u0026ndash;4]. Other characteristics affecting prognosis include positive margin, extracapsular extension, bone and perineural invasions [1].\u003c/p\u003e\n\u003cp\u003eHowever, it is difficult to compare studies owing to differences in the number of patients enrolled in each study, pathological types, and treatment strategies. Intensity-modulated radiotherapy (IMRT) has led to increased treatment accuracy and the possibility of delivering higher doses to the tumor region. This suggests that previous studies that included patients who were irradiated using conventional radiotherapy (RT) or 3-dimensional conformal radiotherapy (3-DCRT) may have yielded lower locoregional control rates. We focused on postoperative IMRT, which was developed to improve local tumor control rate and quality of life and has been widely adopted for the treatment of head and neck cancer in recent decades. Because of the differences in biological behavior between major and minor SGC, prognosis varies considerably. Here,\u0026nbsp;we collected and analyzed comprehensive treatment outcomes for major SGC patients treated with surgery and postoperative IMRT, and explored survival, related adverse prognostic factors, treatment failure patterns, and adverse events.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003ePatients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe retrospectively reviewed 60 patients with histologically confirmed primary SGC treated at the First Affiliated Hospital of Zhejiang University from January 2009 to December 2016. All the patients had newly diagnosed diseases and received upfront surgery followed by external beam RT using IMRT. Patients with recurrent or metastatic disease or those who failed to finish the scheduled RT were excluded.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEvaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll patients were initially evaluated by a multimodality treatment team consisting of an otolaryngologist, a medical oncologist, and a RT oncologist. All patients underwent a detailed physical examination. Histological confirmation of SGC was required before treatment. Axial imaging with computed tomography (CT) was a routine part of patient evaluation, and most patients had also undergone either magnetic resonance imaging (MRI) or positron emission tomography (PET). Histological diagnosis was confirmed according to the WHO histologic subtype criteria for SGC [5]. All patients were restaged based on the 2018 American Joint Committee on Cancer classification.\u0026nbsp;Acute adverse events were graded according to electronic records. Late toxicity was assessed based on follow-up visits.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll patients underwent initial primary resection, with neck dissection (ND) therapeutically (if clinically positive lymph node; cN+) or electively in high-risk cN0 (clinically negative lymph node) patients. For IMRT, patients were immobilized in the supine position with a thermoplastic head\u0026ndash;neck or head\u0026ndash;neck\u0026ndash;shoulder mask to ensure the daily reproducibility of treatments. Simulation CT scan was performed with 3-mm slice thickness and transported to the treatment planning system. Clinical target volume (CTV) was defined as postoperative tumor bed and the elective nodal area (Figure 1). Elective nodal irradiation target volume comprised the positive lymph nodal areas plus at least one level beyond. Organ-at-risk volumes (spinal cord, optic apparatus, mandible) were delineated\u0026nbsp;on each slice. The maximal dose constraints were below 45 Gy for the spinal cord, 55 Gy for the optic apparatus, and 70 Gy for the mandible. For the planning target volume (PTV), a 0.3-cm margin was applied to the CTV considering daily setup error. The prescribed dose was 60\u0026ndash;68 Gy, administered at a daily 2 Gy/fraction, 5 days/week over 6\u0026ndash;6.8 weeks (30\u0026ndash;34 fractions).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFigure 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eChemotherapy was administered to patients with advanced disease or in the presence of high pathological risk factors. Cisplatin (80 mg/m\u003csup\u003e2\u003c/sup\u003e intravenously every 3 weeks) was the most commonly used concomitant chemotherapy schedule. Several patients received adjuvant chemotherapy of cisplatin (80 mg/m\u003csup\u003e2\u003c/sup\u003e intravenously, day 1) and 5-FU (1000\u0026nbsp;mg/m\u003csup\u003e2 \u003c/sup\u003econtinuous infusion over 120\u0026nbsp;h), or cisplatin (80 mg/m\u003csup\u003e2\u003c/sup\u003e intravenously, day 1) and capecitabine (1250\u0026nbsp;mg/m\u003csup\u003e2\u003c/sup\u003e orally twice a day, day 1 to day 14) repeated every 3 weeks followed by PORT.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFollow-up \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAfter treatment completion, patients were evaluated every 3 months for the first 1 year, every 3-6 months over the following 4 years, and yearly thereafter. At each follow-up visit, a physical examination and imaging were performed, including fiberoptic endoscopy if indicated. A PET scan was performed if recurrence or metastasis was suspected. Overall survival (OS) was defined as the time from surgery to the date of death; progression-free survival (PFS) as the time from surgery to the date of local or regional recurrence, distant metastases, or death from any cause; locoregional relapse-free survival (LRRFS) as absence of disease recurrence in the local site or regional lymph node; and distant metastasis-free survival (DMFS) as the time to distant metastasis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSurvival was analyzed using the Kaplan\u0026ndash;Meier method and compared using the log-rank test. A Cox proportional hazards regression model was used for multivariable analysis (MVA). \u003cem\u003ep\u003c/em\u003e\u0026lt;0.05 was considered significant. Statistical tests were two-sided. All data were analyzed using SPSS 20.0.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eClinicopathological characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePatient characteristics are summarized in Table 1. The median follow-up was 55.5 months (range 1\u0026ndash;114 months). Median age at initial diagnosis was 52 years (range 15\u0026ndash;76 years). Among the patients, 35 (58.3%) were male and 25 (41.7%) female. Median tumor size was 2.5 cm (range 1\u0026ndash;15 cm). Most patients presented with a palpable mass at initial presentation. Twenty-three (38.3%) experienced pain and 5 (8.3%) showed facial nerve paralysis. In some patients, painless masses had remained stable for several years and then began to grow rapidly. Histologic types included ACC in 21 patients (35%), lymphoepithelial carcinoma (LELC) in 12 (20%), mucoepidermoid carcinoma (MEC) in 8 (13.3%), salivary duct carcinoma (SDC) in 5 (8.3%), squamous cell carcinoma (SCC) in 4 (6.7%), basal cell adenocarcinoma (BCAC) in 3 (5%), myoepithelial carcinoma in 2 (3.3%), acinic cell carcinoma (AcCC) in 1 (1.7%), and others in 4 (6.7%). The primary sites were the parotid gland in 34 patients (56.7%), submandibular gland in 17 (28.3%), and sublingual gland in 9 (15%). The T stage distribution was 14 (23.3%) T1\u0026ndash;T2 and 46 (76.7%) T3\u0026ndash;T4b. The N stage distribution was 41 (68.3%) N0, 8 (13.3%) N1, 8 (13.3%) N2b, and 3 (5%) N2c. Eleven (18.3%) presented with stage Ⅰ\u0026ndash;Ⅱ disease and 49 (81.7%) with stage Ⅲ\u0026ndash;Ⅳb. Skin involvement was observed in 5 patients (8.3%), positive margin in 7 (11.7%), extra-parenchymal extension in 34 (56.7%), perineural invasion in 19 (31.7%), and major nerve involvement in 28 (46.7%).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll patients received primary tumor resection with curative intention; 42 (70%) received concurrent ND, 19 of which (31.7%) had pathologic evidence of N+. The median interval from surgery to RT was 30 days. The median dose to the tumor bed was 63 Gy (range 60\u0026ndash;68 Gy). Four patients (6.7%) received tumor bed irradiation only. Forty-nine (81.7%) were treated with tumor bed and unilateral neck nodal irradiation, while the rest received tumor bed and bilateral neck nodal irradiation. Four patients received concurrent three-weekly cisplatin chemotherapy. Two received\u0026nbsp;\u003ca href=\"https://www.sciencedirect.com/topics/medicine-and-dentistry/adjuvant-chemotherapy\"\u003eadjuvant chemotherapy\u003c/a\u003e\u0026nbsp;after PORT, one with cisplatin and 5-FU and the other with cisplatin and capecitabine.\u0026nbsp;Of the 4 patients who received chemotherapy, 2 exhibited advanced nodal stage (N2b) and 2 major nerve involvement; all presented with stage T3\u0026ndash;T4 disease.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSurvival\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eKaplan\u0026ndash;Meier curves for OS, PFS, LRRFS, and DMFS are shown in Figure 2. The 3-, 5-, and 10-year OS was 90.7%, 85.1%, and 85.1%, while that for PFS was 80.1%,72.7%, and 63.1%, respectively. The 3-, 5-, and 10-year LRRFS was 87.4%, 82.1%, and 82.1%, while that for DMFS was 85.3%, 78.4%, and 66.1%, respectively.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFigure 2\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrognostic factors for OS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eRisk factors for survival are summarized in Table 2\u0026amp;Additional file 1. Univariable analysis (UVA) suggested that a higher N stage was associated with decreased survival, with patients having stage N0 disease surviving significantly longer than those with stages N1, N2b, and N2c (\u003cem\u003ep\u003c/em\u003e=0.025).\u0026nbsp;Primary site was a prognostic factor for OS, with 5-year OS rates of 90%, 67.6%, and 100% for parotid, submandibular, and sublingual gland tumors (\u003cem\u003ep\u003c/em\u003e=0.039). However, no significant association was found between OS and N stage or primary site in MVA.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrognostic factors for PFS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBased on our log-rank test, gender was strongly associated with PFS (\u003cem\u003ep\u003c/em\u003e=0.018), although it did not reach significance as a predictor in MVA. For patients with and without major nerve involvement, the 5-year PFS was 85% and 59.5% (\u003cem\u003ep\u003c/em\u003e=0.019), respectively.\u0026nbsp;Notably, when interval from surgery to RT was analyzed as a categorical variable using the median interval of 30 days as a cutpoint, a significant difference in PFS was observed (\u003cem\u003ep\u003c/em\u003e=0.044). No significant difference in PFS was observed among patients with N stage and positive margin in UVA (\u003cem\u003ep\u003c/em\u003e=0.164, 0.092). MVA indicated that major nerve involvement (hazard ratio [HR]=2.394, 95% confidence interval [CI]=0.664\u0026ndash;8.89, \u003cem\u003ep\u003c/em\u003e=0.034), N stage (HR=0.089, 95% CI=0.008\u0026ndash;0.964, \u003cem\u003ep\u003c/em\u003e=0.047), positive margin (HR=4.086, 95% CI=1.097\u0026ndash;15.219, \u003cem\u003ep\u003c/em\u003e=0.036), and interval from surgery to RT (HR=3.934, 95% CI=1.097\u0026ndash;14.105, \u003cem\u003ep\u003c/em\u003e=0.036) were significant independent predictors\u0026nbsp;of PFS (Figure 3).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional file 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFigure 3\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrognostic factors for LRRFS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn UVA, the 5-year LRRFS for patients with positive margin was 57.1%, compared with 85.9% for those with negative margin (\u003cem\u003ep\u003c/em\u003e=0.029). In MVA, positive margin was an independent predictor for LRRFS (HR=5.064, 95% CI=1.211\u0026ndash;21.187, \u003cem\u003ep\u003c/em\u003e=0.026) (Figure 4).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrognostic factors for DMFS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMajor nerve involvement, N stage, and clinical stage were prognostic factors for poor DMFS in UVA (\u003cem\u003ep\u003c/em\u003e=0.024, 0.014, and 0.049, respectively). When a Cox proportional hazards regression model was used to predict distant metastases, major nerve involvement (HR=2.115, 95% CI=0.521\u0026ndash;8.583, \u003cem\u003ep\u003c/em\u003e=0.008), positive margin (HR=6.367, 95% CI=1.524\u0026ndash;26.603, \u003cem\u003ep\u003c/em\u003e=0.011), and interval from surgery to RT (HR=6.231, 95% CI=1.503\u0026ndash;25.829, \u003cem\u003ep\u003c/em\u003e=0.012) were identified as independent predictors of distant metastases (Figure 4).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFigure 4\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp; In ACC subgroup analysis, 5-year OS, PFS, LRRFS, and DMFS were 100%, 67.7%, 76.2%, and 90.2%, respectively. In UVA, perineural invasion was significantly associated with PFS and DMFS (\u003cem\u003ep\u003c/em\u003e=0.021 and 0.026, respectively); major nerve involvement was was strongly associated with PFS (\u003cem\u003ep\u003c/em\u003e=0.014); parotid gland and N stage were associated with poor LRRFS (\u003cem\u003ep\u003c/em\u003e=0.041 and 0.023, respectively); and positive margin was an important prognostic factor for PFS, LRRFS, and DMFS (\u003cem\u003ep\u003c/em\u003e=0.021, 0.002, and 0.021, respectively). However, there were too few ACCs to allow for MVA. For detailed information see Table 3.\u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAdverse events \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe most acute adverse events were grade Ⅱ/Ⅲ mucositis (\u003cem\u003en\u003c/em\u003e=44, 73.3%) and gradeⅠ/Ⅱ dermatitis (\u003cem\u003en\u003c/em\u003e=46, 76.7%). \u003ca href=\"https://www.sciencedirect.com/topics/medicine-and-dentistry/xerostomia\"\u003eXerostomia\u003c/a\u003e was the most common late adverse event (\u003cem\u003en\u003c/em\u003e=18, 30%), followed by hearing impairment (\u003cem\u003en\u003c/em\u003e=17, 28.4%), taste abnormalities (\u003cem\u003en\u003c/em\u003e=15, 25%), paresthesia (\u003cem\u003en\u003c/em\u003e=14, 23.3%), fibrosis of the skin (\u003cem\u003en\u003c/em\u003e=11, 18.3%), trismus (\u003cem\u003en\u003c/em\u003e=6, 10%), and osteoradionecrosis (\u003cem\u003en\u003c/em\u003e=2, 3.3%). No grade 4 acute or late adverse events were observed.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePatterns of failure\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTreatment failure occurred in 16 (26.7%) of the 60 patients (Figure 5). Locoregional recurrence occurred in 9 (15%), local failure in 8 (13.3%), and regional failure in 3 (5%). Distant metastasis occurred in 14 patients (23.3%). In the 7 patients with distance-related failure, metastasis was accompanied by locoregional recurrence. The median time to distant metastasis was 49.5 months. Distant metastasis occurred in the lung (\u003cem\u003en\u003c/em\u003e=10, 16.7%), bones (\u003cem\u003en\u003c/em\u003e=3, 5%), brain (\u003cem\u003en\u003c/em\u003e=1, 1.7%), elsewhere (\u003cem\u003en\u003c/em\u003e=1, 1.7%), and at multiple sites (\u003cem\u003en\u003c/em\u003e=2, 3.3%).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis retrospective study focused on the clinical outcomes, prognostic factors, failure patterns, and adverse events in patients with major SGC treated with surgery and postoperative IMRT. Similar to that reported in the literature [3,6,7], our study showed that ACC was the most common histology, followed by LELC. As histology is an important prognostic factor, for SDC, adenocarcinoma and undifferentiated carcinoma have worse prognosis [8,9], we performed an ACC subgroup analysis. Our clinical cohort exhibited excellent clinical outcomes that compared very favorably with those reported in the literature [10].\u003c/p\u003e\n\u003cp\u003eOur MVA showed that N stage, positive margin, major nerve involvement, and interval from surgery to RT were unfavorable prognostic factors. With regard to the relationship between clinicopathologic parameters and OS, there was no negative prognostic factor for survival in MVA. Probable reason was\u0026nbsp;excellent survival of our patients. Although\u0026nbsp;positive margin and N stage were not prognostic factors for\u0026nbsp;PFS in the UVA, and neither was\u0026nbsp;N stage for\u0026nbsp;LRRFS, we\u0026nbsp;nevertheless included them\u0026nbsp;in the Cox proportional hazards regression model as positive margin and positive lymph nodes were previously shown to be important predictive factors for SGC [3,11\u0026ndash;13]. After adjusting for factors that might affect prognosis, N stage and positive margin were found to be independent prognostic factors for PFS, although N stage was not a predictive factor for LRRFS. Positive margin was also an independent prognostic factor for LRRFS and DMFS, suggesting that margin status information should be included in clinical pathology reports. Major nerve involvement was an independent prognostic factor for poor PFS and DMFS, while a time from surgery to RT \u0026gt;30 days resulted in worse PFS and DMFS.\u003c/p\u003e\n\u003cp\u003eCombination treatment modalities are usually required for SGC. Surgical resection followed by PORT is practical and effective at increasing survival and locoregional control rates in patients with a tumor size \u0026ge;4 cm, deep lobe settlement, high grade, positive margin, local advanced stage, lymph node metastasis, soft tissue or bone infiltration, and perivascular and perineural invasion [14\u0026ndash;17]. Terhaard et al. revealed that the 5- and 10-year actuarial local control rates were significantly higher for PORT \u003cem\u003evs\u003c/em\u003e surgery alone (94% \u003cem\u003evs\u003c/em\u003e 84% and 91% \u003cem\u003evs\u003c/em\u003e 76%, respectively) (\u003cem\u003ep\u003c/em\u003e=0.0005) [18].\u003c/p\u003e\n\u003cp\u003eA comparison of our outcomes with those of other institutions is difficult because of different case mix and wide variety of histological subtypes involved. Overall, the outcomes in our study are better than those reported for historical data of other institutions using PORT use for SGC treatment (5-year OS: 85.1% \u003cem\u003evs\u003c/em\u003e 61%\u0026ndash;74%; 10-year OS: 85.1% \u003cem\u003evs\u003c/em\u003e 48%\u0026ndash;71%) [15,16,19\u0026ndash;21]. The better survival rates in this series could be explained by a \u0026ldquo;cohort effect\u0026rdquo; resulting from improved diagnostic capabilities and treatment modalities. Previous studies have involved conventional RT or 3-DCRT treatment; however, all the patients in this study received IMRT. Compared with conventional RT or 3-DCRT, IMRT permits a greater precision and modulation of the RT beam to keep high doses away from vital structures. This offers improved locoregional control in SGC patients, which corresponds to better OS [22,23]. Furthermore, because a greater amount of normal tissue is spared, IMRT is less toxic, resulting in a smaller impact on quality of life\u0026nbsp;[24]. Our patients exhibited a reduced incidence of xerostomia (30%) compared with those from historical studies (83%) [25].\u003c/p\u003e\n\u003cp\u003eIn agreement with the published literature [26,27], distant metastasis was the predominant mode of failure, highlighting the need for effective systemic therapies. Chemotherapy is generally reserved for the palliative treatment of symptomatic locally recurrent or metastatic disease, and has a limited effect [28]. Recent studies have also indicated that postoperative chemoradiotherapy (POCRT) promotes higher survival and locoregional control than PORT treatment alone [29\u0026ndash;32]. However, no significant differences in DMFS, disease-free survival, and OS were observed when adding concurrent chemotherapy to PORT, while POCRT has been associated with increased mortality and toxicity [31,33]. We could not evaluate the effect of POCRT on outcomes owing to the small number of patients who received chemotherapy.\u003c/p\u003e\n\u003cp\u003eOur study had several significant limitations. The small sample size did permit an evaluation of outcome stratified by various histological subtypes. Additionally, our median follow-up was approximately 55.5 months, and median OS, PFS, LRRFS, and DMFS were not reached. Lastly, The pathological detection of SGC margin status and perineural invasion may vary greatly depending on the extent of sampling. Nevertheless, our observations have potential for use in the design of prospective SGC clinical trials.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eOur series of 60 SGC patients showed that postoperative IMRT leds to improved OS for SGC with acceptable toxicities. N stage, positive margin, major nerve involvement and interval from surgery to RT were important factors that were associated with oncological outcomes.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eSGC: salivary gland cancer; 3-DCRT: 3-dimensional conformal radiotherapy; IMRT: intensity-modulated radiotherapy; OS: overall survival; PFS: progression-free survival; LRRFS: locoregional relapse-free survival; DMFS: distant metastasis-free survival; ACC: adenoid cystic carcinoma; MVA: multivariable analysis; RT: radiotherapy; PORT: postoperative radiotherapy; CT: computed tomography; MRI: magnetic resonance imaging; PET: positron emission tomography; ND: neck dissection; CTV: Clinical target volume; PTV: planning target volume; MEC: mucoepidermoid carcinoma; LELC: lymphoepithelioid carcinoma; SDC: salivary duct carcinoma; SCC: squamous cell carcinoma; BCAC: basal cell adenocarcinoma; AcCC: acinic cell carcinoma; UVA: Univariable analysis; POCRT: postoperative chemoradiotherapy\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the Institutional Review Board of the First Affiliated Hospital, Zhejiang University. And written informed consents were obtained.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere are no conflicts to declare.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was independent research funded by the Department of Health of Zhejiang Province (2018265493, 2017197137). The fund had no role in study design, or data analysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u003c/strong\u003e\u003cstrong\u003e\u0026rsquo;\u003c/strong\u003e\u003cstrong\u003econtributions \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSZ: Collection and analysis of data, manuscript writing; MC: Collection and analysis of data; XZ \u0026amp; HH: Collect and contribution of data, supervision; DF and SY: Conceptual design, supervision, critical revision of intellectual contents. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003cbr /\u003e Not applicable.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e[1] Ata-Ali J, Zurriaga O, Alberich C. Incidence and survival rates for malignant salivary gland tumors. J Oral Sci 2016;58:67\u0026ndash;73.\u003c/p\u003e\n\u003cp\u003e[2] Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986;8:177\u0026ndash;84.\u003c/p\u003e\n\u003cp\u003e[3] Terhaard CH, Lubsen H, Van der Tweel I, Hilgers FJ, Eijkenboom WM, Marres HA, et al. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 2004;26:681\u0026ndash;92; discussion 692\u0026ndash;3.\u003c/p\u003e\n\u003cp\u003e[4] Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, et al. Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg 2005;133:702\u0026ndash;8.\u003c/p\u003e\n\u003cp\u003e[5] Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 2006;85:74\u003c/p\u003e\n\u003cp\u003e[6] Bell RB, Dierks EJ, Homer L, Potter BE. Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg 2005;63:917\u0026ndash;28.\u003c/p\u003e\n\u003cp\u003e[7] Kaur J, Goyal S, Muzumder S, Bhasker S, Mohanti BK, Rath GK. Outcome of surgery and post-operative radiotherapy for major salivary gland carcinoma: ten year experience from a single institute. Asian Pac J Cancer Prev 2014;15:8259\u0026ndash;63.\u003c/p\u003e\n\u003cp\u003e[8] Wahlberg P, Anderson H, Biorklund A, Moller T, Perfekt R. Carcinoma of the parotid and submandibular glands--a study of survival in 2465 patients. Oral Oncol 2002;38:706\u0026ndash;13.\u003c/p\u003e\n\u003cp\u003e[9] Jang JY, Choi N, Ko YH, Chung MK, Son YI, Baek CH, et al. Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer 2018;18:672.\u003c/p\u003e\n\u003cp\u003e[10] Ali S, Palmer FL, Katabi N, Lee N, Shah JP, Patel SG, et al. Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation. Laryngoscope 2017;127:2265\u0026ndash;9.\u003c/p\u003e\n\u003cp\u003e[11] Qian K, Di L, Guo K, Zheng X, Ji Q, Wang Z. Cervical Lymph Node Metastatic Status and Adjuvant Therapy Predict the Prognosis of Salivary Duct Carcinoma. J Oral Maxillofac Surg 2018;76:1578\u0026ndash;86.\u003c/p\u003e\n\u003cp\u003e[12] Yoo SH, Roh JL, Kim SO, Cho KJ, Choi SH, Nam SY, et al. Patterns and treatment of neck metastases in patients with salivary gland cancers. J Surg Oncol 2015;111:1000\u0026ndash;6.\u003c/p\u003e\n\u003cp\u003e[13] Johnston ML, Huang SH, Waldron JN, Atenafu EG, Chan K, Cummings BJ, et al. Salivary duct carcinoma: Treatment, outcomes, and patterns of failure. Head Neck 2016;38 Suppl 1:E820\u0026ndash;6.\u003c/p\u003e\n\u003cp\u003e[14] Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, et al. A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network). Crit Rev Oncol Hematol 2014;91:142\u0026ndash;58.\u003c/p\u003e\n\u003cp\u003e[15] Storey MR, Garden AS, Morrison WH, Eicher SA, Schechter NR, Ang KK. Postoperative radiotherapy for malignant tumors of the submandibular gland. Int J Radiat Oncol Biol Phys 2001;51:952\u0026ndash;8.\u003c/p\u003e\n\u003cp\u003e[16] North CA, Lee DJ, Piantadosi S, Zahurak M, Johns ME. Carcinoma of the major salivary glands treated by surgery or surgery plus postoperative radiotherapy. Int J Radiat Oncol Biol Phys 1990;18:1319\u0026ndash;26.\u003c/p\u003e\n\u003cp\u003e[17] Pohar S, Gay H, Rosenbaum P, Klish D, Bogart J, Sagerman R, et al. Malignant parotid tumors: presentation, clinical/pathologic prognostic factors, and treatment outcomes. Int J Radiat Oncol Biol Phys 2005;61:112\u0026ndash;8.\u003c/p\u003e\n\u003cp\u003e[18] Terhaard CH, Lubsen H, Rasch CR, Levendag PC, Kaanders HH, Tjho-Heslinga RE, et al. The role of radiotherapy in the treatment of malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 2005;61:103\u0026ndash;11.\u003c/p\u003e\n\u003cp\u003e[19] Toonkel LM, Guha S, Foster P, Dembrow V. Radiotherapy for parotid cancer. Ann Surg Oncol 1994;1:468\u0026ndash;72.\u003c/p\u003e\n\u003cp\u003e[20] Fitzpatrick PJ, Theriault C. Malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 1986;12:1743\u0026ndash;7.\u003c/p\u003e\n\u003cp\u003e[21] Bhide SA, Miah A, Barbachano Y, Harrington KJ, Newbold K, Nutting CM. Radical radiotherapy for treatment of malignant parotid tumours: a single centre experience. 1995\u0026ndash;2005. Br J Oral Maxillofac Surg 2009;47:284\u0026ndash;9.\u003c/p\u003e\n\u003cp\u003e[22] Chen JL, Huang YS, Kuo SH, Hong RL, Ko JY, Lou PJ, et al. Intensity-modulated radiation therapy achieves better local control compared to three-dimensional conformal radiation therapy for T4-stage nasopharyngeal carcinoma. Oncotarget 2017;8:14068\u0026ndash;77.\u003c/p\u003e\n\u003cp\u003e[23] Hosni A, Huang SH, Goldstein D, Xu W, Chan B, Hansen A, et al. Outcomes and prognostic factors for major salivary gland carcinoma following postoperative radiotherapy. Oral Oncol 2016;54:75\u0026ndash;80.\u003c/p\u003e\n\u003cp\u003e[24] van der Veen J, Nuyts S. Can Intensity-Modulated-Radiotherapy Reduce Toxicity in Head and Neck Squamous Cell Carcinoma? Cancers. 2017;9(10). pii: E135.\u003c/p\u003e\n\u003cp\u003e[25] Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 2011;12:127\u0026ndash;36.\u003c/p\u003e\n\u003cp\u003e[26] Samant S, van den Brekel MW, Kies MS, Wan J, Robbins KT, Rosenthal DI, et al. Concurrent chemoradiation for adenoid cystic carcinoma of the head and neck. Head Neck 2012;34:1263\u0026ndash;8.\u003c/p\u003e\n\u003cp\u003e[27] Hosal AS, Fan C, Barnes L, Myers EN. Salivary duct carcinoma. Otolaryngol Head Neck Surg 2003;129:720\u0026ndash;5.\u003c/p\u003e\n\u003cp\u003e[28] Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Keus RB, Hart AA. Stage as major long term outcome predictor in minor salivary gland carcinoma. Cancer 2000;89:1195\u0026ndash;204.\u003c/p\u003e\n\u003cp\u003e[29] Tanvetyanon T, Qin D, Padhya T, McCaffrey J, Zhu W, Boulware D, et al. Outcomes of postoperative concurrent chemoradiotherapy for locally advanced major salivary gland carcinoma. Arch Otolaryngol Head Neck Surg 2009;135:687\u0026ndash;92.\u003c/p\u003e\n\u003cp\u003e[30] Maruya S, Namba A, Matsubara A, Kakehata S, Takeda I, Shirasaki T, et al. Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel. Int J Clin Oncol 2006;11:403\u0026ndash;6.\u003c/p\u003e\n\u003cp\u003e[31] Hsieh CE, Lin CY, Lee LY, Yang LY, Wang CC, Wang HM, et al. Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study. Radiat Oncol 2016;11:47.\u003c/p\u003e\n\u003cp\u003e[32] Schoenfeld JD, Sher DJ, Norris CM, Jr., Haddad RI, Posner MR, Balboni TA, et al. Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy. Int J Radiat Oncol Biol Phys 2012;82:308\u0026ndash;14.\u003c/p\u003e\n\u003cp\u003e[33] Tanvetyanon T, Fisher K, Caudell J, Otto K, Padhya T, Trotti A. Adjuvant chemoradiotherapy versus with radiotherapy alone for locally advanced salivary gland carcinoma among older patients. Head Neck 2016;38:863\u0026ndash;70.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style=\"text-align: justify; line-height: 200%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eTable 1\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e. Characteristics of the 60 SGC patients\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eCharacteristics \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eoutcome (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eCharacteristics\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eoutcome (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMedian age (yr)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eClinical\u0026nbsp;stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eGender\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003eⅠ\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e-\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003eⅡ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e11 (18.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e35 (58.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003eⅢ\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e-\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003eⅣ\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eb\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e49 (81.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eFemale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e25 (41.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSkin involvement\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePrimary site\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e5 (8.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eParotid gland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e34 (56.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e55 (91.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSubmandibular gland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e17 (28.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMargin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSublingual gland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e9 (15%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePositive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e7(11.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMedian size of tumor (cm)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e2.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e53 (88.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eExtra-parenchymal extension\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e23 (38.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e34 (56.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e37 (61.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e26 (43.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eFacial nerve paralysis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePerineural invasion\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e5 (8.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e19 (31.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e55 (91.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e41 (68.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eHistologic types\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMajor nerve involvement\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eACC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e21 (35%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePositive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e28 (46.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eLELC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e12 (20%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e32 (53.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMEC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e8 (13.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSurgery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSDC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e5 (8.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePrimary tumor resection\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e18 (30%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSCC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e4 (6.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePrimary tumor resection + ND\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e42 (70%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eBCAC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e3 (5.0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eInterval from surgery to RT (d)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMyoepithelial carcinoma\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e2 (3.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e\u0026le; 30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e30 (50%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eAcCC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e1 (1.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e30 (50%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eOthers\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e4 (6.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eRadiotherapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify; line-height: 200%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eTable 1\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e. Characteristics of the 60 SGC patients(Continued)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eCharacteristics \u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eoutcome (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eCharacteristics\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eoutcome (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eT stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eTumor bed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e4 (6.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eT1-T2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e14 (23.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eTumor bed+unilateral neck\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e49 (81.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eT3-T4b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e46 (76.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eTumor bed+bilateral neck\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e7 (11.6%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMedian dose\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eGy\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e41 (68.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eChemoradiotherapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e8 (13.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e4 (6.7%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN2b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e8 (13.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e56 (93.3%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 125.9pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN2c\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e3 (5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 141.75pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; padding: 0in 5.4pt; vertical-align: top;\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify; line-height: 200%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"line-height: 200%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eACC, adenoid cystic carcinoma; MEC, mucoepidermoid carcinoma; LELC, lymphoepithelioid carcinoma; SDC, salivary duct carcinoma; SCC, squamous cell carcinoma; BCAC, basal cell adenocarcinoma; AcCC, acinic cell carcinoma; RT, radiotherapy; ND, neck dissection.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify; line-height: 150%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"line-height: 150%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"line-height: 150%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify; line-height: 200%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif';\"\u003eTable 2\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif';\"\u003e. Univariable analysis (UVA) and multivariable analysis (MVA) for overall survival (OS) and progression-free survival (PFS)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eVariables\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eNumber\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 133.4pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eOS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 172.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ePFS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 34.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eat 5y(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eUVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eMVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eat 5y(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eUVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eMVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ep\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eHR 95%CI P\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ep\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eHR 95%CI P\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eGender\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.989\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.018\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eMale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e35\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e84.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e62.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eFemale\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e85.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e87.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eAge(y)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.228\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.172\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026le;52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e90.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e77.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun; color: black; background: white;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e29\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e80.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e66.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ePerineural invasion\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.373\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.951\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e84.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e71.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e94.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e77.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eMajor never involvement\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.665\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.019\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e2.394 0.664-8.896 0.034\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eNegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e82.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e85.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ePositive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e86.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e59.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eExtra-parenchymal extension\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.268\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.581\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e26\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e95.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e71.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e82.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e74.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ePrimary site\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.039\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.641\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eParotid gland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e90.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e70.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSubmandibular gland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e67.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e64.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSublingual gland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e100.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e88.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: justify; line-height: 200%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: justify; line-height: 200%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif';\"\u003eTable 2\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 16px; line-height: 200%; font-family: 'Times New Roman','serif';\"\u003e. Univariable analysis (UVA) and multivariable analysis (MVA) for overall survival (OS) and progression-free survival (PFS) \u003cspan style=\"color: black; background: white;\"\u003e(Continued)\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eVariables\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eNumber\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 133.4pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eOS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 172.6pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"3\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ePFS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 34.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eat 5y(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eUVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eMVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eat 5y(%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eUVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eMVA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ep\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eHR 95%CI P\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003ep\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003eHR 95%CI P\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eT stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.154\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.244\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eT1-T2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e100.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e79.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eT3-T4b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e81.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e71.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.025\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.164\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.089 0.008-0.964 0.047\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e91.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e78.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN2b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e43.8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e60.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eN2c\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eClinical stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.188\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.141\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: SimSun;\"\u003eⅠ\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e-\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: SimSun;\"\u003eⅡ\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e100.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e85.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: SimSun;\"\u003eⅢ\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e-\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: SimSun;\"\u003eⅣ\u003c/span\u003e\u003cspan style=\"font-size: 13px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eb\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e81.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e70.5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eMargin\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.206\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.092\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e4.086 1.097-15.219 0.036\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003ePositive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e88.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e74.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNegative\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e64.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e57.1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eSkin involvement\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.550\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.458\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e55\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e85.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e75.3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e80.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e40.0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003eInterval from surgery to RT (d)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.635\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e0.044\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e3.934 1.097-14.105 0.036\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e\u0026le; 30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e84.7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e85.2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: SimSun;\"\u003e＞\u003c/span\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif';\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 40.3pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e84.4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 35.4pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e59.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 31.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\"\u003e\n\u003cp style=\"text-align: justify; line-height: 107%; font-size: 14px; font-family: 'Calibri','sans-serif'; margin: 0in 0in 8.0pt 0in;\"\u003e\u003cspan style=\"font-size: 12px; line-height: 107%; font-family: 'Times New Roman','serif'; color: black; background: white;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\u003cp\u003e\u003cstrong\u003eTable \u003c/strong\u003e\u003cstrong\u003e3\u003c/strong\u003e. Univariable analysis (UVA) of prognostic factors for adenoid cystic carcinoma (ACC)\u003c/p\u003e\n\u003ctable float=\"Yes\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" width=\"111\"\u003e\n\u003cp\u003eVariables\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" width=\"59\"\u003e\n\u003cp\u003eNumber\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" width=\"35\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"95\"\u003e\n\u003cp\u003ePFS\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"116\"\u003e\n\u003cp\u003eLRRFS\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" width=\"101\"\u003e\n\u003cp\u003eDMFS\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003eat 5y（%）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003eUAV\u003c/p\u003e\n\u003cp\u003ep\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003eat 5y (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003eUAV\u003c/p\u003e\n\u003cp\u003ep\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003eat \u0026nbsp;5y\u003c/p\u003e\n\u003cp\u003e(%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003eUAV\u003c/p\u003e\n\u003cp\u003ep\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003ePerineural invasion\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"18\" width=\"35\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e0.021\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e0.026\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eNo\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e100\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eYes\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eMajor nerve involvement\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e0.014\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eNegative\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e100\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003ePositive\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eMargin\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e0.021\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e0.021\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eNegative\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e70.8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e94.4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003ePositive\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003ePrimary site\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e0.041\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eParotid \u0026nbsp;gland\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e66.7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eSubmandibular gland\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e100\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eSublingual gland\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eN stage\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e0.023\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eN0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eN1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eN2b\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"111\"\u003e\n\u003cp\u003eN2c\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"59\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"45\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"65\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"16\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"50\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"51\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"salivary gland cancer, IMRT, survival ","lastPublishedDoi":"10.21203/rs.3.rs-33712/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-33712/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eSalivary gland cancer (SGC) is comparatively rare and constitutes a variety of histological subtypes. Previously published studies included SGC patients who were irradiated using conventional radiotherapy or 3-dimensional conformal radiotherapy (3-DCRT) may have led to suboptimal oncological outcomes.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eWe identified 60 patients with major SGC treated with surgery followed by postoperative intensity-modulated radiotherapy (IMRT). Data for overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), prognostic factors, and treatment-related toxicities were analyzed. Survival was analyzed using the Kaplan\u0026ndash;Meier method and compared using the log-rank test.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eAdenoid cystic carcinoma (ACC) was the most common histology (\u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;21; 35%). With a median follow-up of 55.5 months, OS and PFS were 90.7%, 85.1%, and 85.1%; and 80.1%, 72.7%, and 63.1%, at 3, 5, and 10 years, respectively. LRRFS and DMFS at 3, 5, and 10\u0026nbsp;years were 87.4%, 82.1%, and 82.1%; and 85.3%, 78.4%, and 66.1%, respectively. Five-year OS, PFS, LRRFS, and DMFS for ACC was 100%, 67.7%, 76.2%, and 90.2%, respectively. In multivariable analysis (MVA), N stage was an independent predictor of PFS (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.047). Positive margin was a significant prognostic factor for PFS, LRRFS, and DMFS (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.036, 0.026, and 0.011, respectively). Major nerve involvement was significantly correlated with PFS and DMFS (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.034 and 0.008, respectively). Interval from surgery to radiotherapy (RT) predicted PFS and DMFS (\u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.036 and 0.012, respectively). The most common acute toxicities were mucositis and dermatitis, and xerostomia was the most common late adverse event. Lung metastasis was the most common pattern of distant failure.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003ePostoperative IMRT leads to improved survival for SGC patients with acceptable toxicities.\u003c/p\u003e","manuscriptTitle":"Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-06-10 17:17:00","doi":"10.21203/rs.3.rs-33712/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"b6becb4a-3185-466e-a482-4b9651666a8b","owner":[],"postedDate":"June 10th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":116999,"name":"Cancer Biology"},{"id":117000,"name":"Oncology"}],"tags":[],"updatedAt":"2022-03-14T10:08:42+00:00","versionOfRecord":{"articleIdentity":"rs-33712","link":"https://doi.org/10.21037/qims-21-836","journal":{"identity":"quantitative-imaging-in-medicine-and-surgery","isVorOnly":true,"title":"Quantitative Imaging in Medicine and Surgery"},"publishedOn":"2021-01-01 10:08:42","publishedOnDateReadable":"January 1st, 2021"},"versionCreatedAt":"2020-06-10 17:17:00","video":"","vorDoi":"10.21037/qims-21-836","vorDoiUrl":"https://doi.org/10.21037/qims-21-836","workflowStages":[]},"version":"v1","identity":"rs-33712","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-33712","identity":"rs-33712","version":["v1"]},"buildId":"rHA-KDH7Qsr4HCuvH75dn","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}