Management of a dentigerous cyst in a child with hereditary angioedema.

The purpose of this paper was to report the case of an 8-year-old girl with hereditary angioedema (HAE) who underwent 2 oral surgeries for removal of a dentigerous cyst without any significant episode of angioedema. One week after routine radiographic examination revealed an odontogenic cyst, short-term prophylactic therapy (Danazol 600 mg/day) was initiated to avoid an angioedema attack. The cyst was carefully removed under general anesthesia without life-threatening complications. Postoperative prophylactic therapy also was performed. Histopathological exam confirmed the diagnosis of a dentigerous cyst. Nine months after surgery, the cyst recurred and it was successfully removed once more under general anesthesia. The same prophylactic therapy was used, this time with fresh frozen plasma. The case presented showed that the oral management of a pediatric patient with HAE is a high-risk procedure. It can be performed successfully, however, when the involved health professionals are aware of both the risks and preventive strategies.