Influence of different antipsychotic drugs on serum prolactin and abdominal fat deposition of female psychiatric patient

Objective To investigate the clinical effects and influence of different antipsychotic drugs on serum prolactin and abdominal fat deposition of female psychiatric patients. Methods 184 female patients treated in our hospital from M arch 2012 to M arch 2014 were randomly divided into 4 groups,46 cases in each group. Patients in the 4groups were given risperidone( A),aripiprazole( B),sulpiride( C) and perphenazine( D),and the treatment lasted for 8 weeks. The clinical effects were observed,and the serum prolactin and abdominal fat deposition were detected before treatment and at 14,28,56 d after treatment. Results After treatment,the PANSS scores were significantly low er in the four groups,there was no significant difference among the 4 groups( P 0. 05). The serum prolactin levels,subcutaneous adipose and abdominal visceral adipose in group A,group C and group D were significantly higher than those of group B( P 0. 05). M enstruation delayed rate( 4. 35%),menstrual flow reduce rate( 4. 35%),breast sw elling rate( 2. 17%) in group B were significantly low er than those of the other three groups( P 0. 05). Conclusion The effect of aripiprazole on serum prolactin and abdominal fat deposition of female psychiatric patient is slightest among the 4 drugs( risperidone,aripiprazole,sulpiride and perphenazine),it is more suitable for female patients.