Hypertriglyceridemia May be a Key Independent Predicting Factor for Gallbladder Cancer Risk in Gallbladder Stone Disease Patients: A Case-Control Study

Background: Gallbladder stone diseases (GSD) is a main risk factor of gallbladder cancer (GBC). This study aimed to reveal their bridge relating to metabolic syndrome. Material: /Method We summarized the clinical and experimental data of 2210 GBC patients, from 3524 Chinese patients, in our hospital from Jan. 2009 to Dec. 2020. The metabolic syndrome indexes, influencing factors for both GBC and GSD, were analyzed by unconditional logistic regression in this case-control study. Result: There were significant higher morbidity of GBC in the overall, GSD and non-GSD with hypertriglyceridemia patients versus non-hypertriglyceridemia ones (P<0.001, all). In GSD patients, univariate regression showed significantly positive correlation between serum triglyceride, low density lipoprotein cholesterol (LDL-c), fasting insulin (FINS) levels, Homeostasis model assessment-insulin resistance (HOMA-IR), female being, body mass index, hypertriglyceridemia and hazard of GBC with GSD (P<0.001, all), while significantly negative correlation to systolic pressure (SBP), diastolic pressure (DBP), hypertension and high-density lipoprotein cholesterol (HDL-c), fasting blood glucose (FBG) (P<0.05, all); multivariate regression showed that serum triglyceride, was the most significantly positive associated to GBC (P<0.001, all) among the hazard factors including serum triglyceride, LDL-c levels, HOMA-IR, female being. In non-GSD ones, multivariate regression showed that HOMA-IR was the most significantly positive associated to GBC among the hazard factors including serum TG, LDL-c levels, HOMA-IR, female being, hypertriglyceridemia, while DM had a significantly inversion negative association (P<0.001). Conclusion: We found initially that hypertriglyceridemia could be the remarkable independent predicting factor of GBC risk with GSD, while insulin resistance might act as the first one in non-GSD. Thus, we advocated initially the sharp rise of serum TG levels as the potential of a candidate diagnostic or prognostic biomarker of GBC with GSD.