[Endometriosis and endometriosis-related ovarian neoplasms].

Tihomir Totev, T Totev, S Tomov, Tomov S, G Gorchev, Gorchev G
Akusherstvo i ginekologiia · 2013 · vol. 52(6) , pp. 38–42 · PMID:24501879 · W76148665
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-07, 2026-07-29 ⓘ

Endometriosis, an estrogen-dependent disorder, increases the risk of clear cell and endometrioid ovarian cancer through pathways involving oxidative stress, inflammation, and hyperestrogenism, with atypical endometriosis acting as an intermediate lesion.

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Abstract

Endometriosis is an estrogen-dependent, chronic gynecological disorder. Although endometriosis is a benign lesion, it shares several common characteristics with invasive cancer. Numerous epidemiologic studies indicate, that endometriosis patients have an increased risk of clear cell and endometrioid ovarian cancer. There is an intermediary lesion between endometriosis and malignant neoplasms - "atypical endometriosis". Genetic factors play a role in the malignant transformation through pathways related to oxidative stress, inflammation and hyperestrogenism.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Ovarian Neoplasms Ovary Endometriosis Endometriosis Endometrium Female Humans Ovarian Neoplasms Ovarian Neoplasms Ovary

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europepmc
last seen: 2026-07-31T06:09:14.520117+00:00
openalex
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