Title MiR-188-5p Affects the Progression of Alzheimer's disease by Negatively Regulating Neuritin Expression

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by complex pathobiological characteristics and still lacks accurate biomarkers in early diagnosis. Neuritin (NRN1) is a neurotrophic factor, which has active roles in neuronal plasticity and regeneration. Recent research suggests that Neuritin has been associated with loss of cognitive function, maybe a potential therapeutic target in AD. MethodsWe have clustered the upregulated miRNAs in AD and predicted the target miRNAs of Neuritin by bioinformatics analysis, found miR-188-5p may involve in the development of AD. ResultsIn the present study, we confirm the association between Neuritin and miR-188-5p expression in mice with AD. Besides, we provide evidence for the changes of cognition capacity, miR-188-5p and Neuritin levels in APP/PS1 mice. ConclusionOur results reveal a previously undefined mechanism that miR-188-5p plays a significant role in the development of AD by inhibiting the expression of target protein Neuritin.