Correlation of multiple steroid receptors with histological type and grade in human ovarian cancer

Kühnel R, R Kühnel, Delemarre JF, J F Delemarre, B R Rao, Rao BR, J G Stolk, Stolk JG
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1987 · doi:10.1097/00004347-198709000-00006 · PMID:2828257
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Abstract

One hundred eight human ovarian cancers were analyzed for estrogen (ER), progestin (PgR), and androgen (AR) receptors. The receptor levels were related to histological type and grade of the tumor. There were 103 common epithelial carcinomas subdivided into serous (36), endometrioid (36), mucinous (18), clear cell (5), malignant Brenner (3), mixed epithelial (2), and undifferentiated (3) types. Of the remaining five, four were sex cord-stromal tumors and there was a single case of germ cell tumor. ER was detected in 52%, PgR in 52%, and AR in 91% of the cases. There was no correlation between the presence of ER and AR and the tumor histology. The presence of PgR correlated with the grade of endometrioid carcinoma, while no clear correlation existed for the other tumor types. PgR was absent in the three undifferentiated carcinomas. Interestingly, high PgR levels were detected in the three granulosa cell tumors.
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Correlation of Multiple Steroid Receptors with Histological Type and Grade in Human Ovarian Cancer - R. Kühnel - J. F. M. Delemarre - B. R. Rao - J. G. Stolk Summary One hundred eight human ovarian cancers were analyzed for estrogen (ER), progestin (PgR), and androgen (AR) receptors. The receptor levels were related to histological type and grade of the tumor. There were 103 common epithelial carcinomas subdivided into serous (36), endometrioid (36), mucinous (18), clear cell (5), malignant Brenner (3), mixed epithelial (2), and undifferentiated (3) types. Of the remaining five, four were sex cord-stromal tumors and there was a single case of germ cell tumor. ER was detected in 52%, PgR in 52%, and AR in 91% of the cases. There was no correlation between the presence of ER and AR and the tumor histology. The presence of PgR correlated with the grade of endometrioid carcinoma, while no clear correlation existed for the other tumor types. PgR was absent in the three undifferentiated carcinomas. Interestingly, high PgR levels were detected in the three granulosa cell tumors.

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endometriosis

MeSH descriptors

Ovarian Neoplasms Receptors, Cell Surface Adenocarcinoma Adenocarcinoma Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adult Brenner Tumor Brenner Tumor Carcinoma Carcinoma Child Endometriosis Endometriosis Female Humans Neoplasms, Germ Cell and Embryonal Neoplasms, Germ Cell and Embryonal Ovarian Neoplasms Ovarian Neoplasms

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