“Population pharmacokinetics analyses and therapeutic drug monitoring of vancomycin: a scoping review”.

This scoping review evaluates recent pharmacokinetic models of vancomycin, a critical antibiotic for gram-positive infections. Due to its narrow therapeutic index and significant inter-patient variability, dosing should be guided by blood concentration monitoring rather than standard regimens. A search in PUBMED and EMBASE (January 2020 - July 2023) identified 22 models in adults, 12 of which focused on critical care units. The diverse patient populations included those on continuous renal replacement therapy, pregnant women, and patients with augmented renal clearance. Creatinine clearance was a significant covariate in 80% of models. Larger cohorts are needed to enhance model robustness and applicability.