Effects of 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT

Effects of 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Psychophysiology This is a preprint and has not been peer reviewed. Data may be preliminary. 31 January 2025 V1 Latest version Share on Effects of 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT Authors : Shapour Jaberzadeh 0000-0003-2957-4510 [email protected] , Mona Malekahmad 0000-0003-1546-2817 , Renming Liu , and Maryam Zoghi Authors Info & Affiliations https://doi.org/10.22541/au.173833865.58665611/v1 390 views 218 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a-tPCS M1 , 400 Hz c-tPCS M1 ) on corticospinal excitability (CSE) and corticocortical excitability (CCE) remain underexplored. This study examined the effects of 400 Hz a-tPCS M1 , 400 Hz c-tPCS M1 , and sham stimulation on CSE, CCE, and hand dexterity, providing insights for potential clinical applications in motor deficits. In this double-blinded, randomized, counterbalanced crossover trial, 26 healthy young adults completed three experimental sessions: 400 Hz a-tPCS M1 , 400 Hz c-tPCS M1 , and sham stimulation, spaced 48 hours apart. Transcranial magnetic stimulation assessed CSE and CCE, while the Purdue Pegboard Test (PPT) evaluated hand dexterity. The results showed polarity-specific effects. A single session of 400 Hz a-tPCS M1 significantly increased CSE and improved hand dexterity, evidenced by faster PPT completion times (p 0.05). Sham stimulation showed no significant changes. These findings suggest that 400 Hz a-tPCS M1 enhances motor excitability and dexterity, while 400 Hz c-tPCS M1 selectively reduces CSE. This study lays a foundation for exploring high-frequency tPCS in clinical motor rehabilitation. Supplementary Material File (main_manuscript_(all_sections_figures_table).docx) Download 1.01 MB Information & Authors Information Version history V1 Version 1 31 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Psychophysiology Authors Affiliations Shapour Jaberzadeh 0000-0003-2957-4510 [email protected] Monash University Department of Physiotherapy View all articles by this author Mona Malekahmad 0000-0003-1546-2817 Monash University Department of Physiotherapy View all articles by this author Renming Liu Monash University Department of Physiotherapy View all articles by this author Maryam Zoghi Federation University Australia - Gippsland Campus View all articles by this author Metrics & Citations Metrics Article Usage 390 views 218 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Shapour Jaberzadeh, Mona Malekahmad, Renming Liu, et al. Effects of 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT. Authorea . 31 January 2025. DOI: https://doi.org/10.22541/au.173833865.58665611/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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