5-Hydroxy- and 5-phenyl-substituted 1-[4-(aminoalkoxy)phenyl]-2-phenylbenzene derivatives for the treatment of post menopausal symptoms and intermediates

Compounds of Formula I: [wherein: n is 2 or 3; R is dimethylamino, diethylamino, 1-piperidinyl, 1-pyrrolidinyl, 4-morpholinyl, or 1-hexamethyleneimino; R 1 is hydroxy, phenyl, or mono or di-substituted phenyl (wherein each substituent is independently halo, methyl, hydroxy, C 1 -C 6 -alkoxy, benzyloxy, C 1 -C 6 -alkanoyloxy, benzoyloxy, substituted benzoyloxy (bearing 1 to 3 substituents each of which is independently halo, C 1 -C 4 -loweralkyl, or C 1 -C 4 -loweralkoxy), C 1 -C 5 -alkoxycarbonyloxy, or C 4 -C 6 -alkylsulfonyloxy);; and R 2 is hydrogen, hydroxy, C 1 -C 6 -alkoxy, benzyloxy, C 1 -C 6 -alkanoyloxy, benzoyloxy, substituted benzoyloxy(bearing 1 to 3 substituents each of which is independently halo, C 1 -C 4 -loweralkyl, or C 1 -C 4 -loweralkoxy), C 1 -C 5 -alkoxycarbonyloxy, or C 4 -C 6 -alkylsulfonyloxy] and the pharmaceutically acceptable acid addition salts and solvates thereof, are useful for the treatment of various post menopausal symptoms such as osteoporosis, cardiovascular disease (eg. hyperlipidemia) estrogen-dependent cancer (eg. breast or uterine cancer), uterine fibroid disease, endometriosis, aortal smooth muscle cell proliferation and restenosis. Compounds of Formula IV and of Formula VIII: are also claimed per se where Rn are as defined above, and R 1a and R 2a have the same values as R 1 and R 2 respectively other than they may not be hydroxy (-OH) or contain a hydroxy group.