Substituted 16,17-annellated steroid compounds for use in women's healthcare

The present invention relates to substituted steroid compounds having the formula (I) Wherein R is H or halogen R is H, (1C-4C)alkyl, (1C-4C)acyl, glucuronyl or sulfamoyl R is H or halogen R is H, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl R is methyl or ethyl R is H or methyl R is H or methyl R is H or acyl for use in the treatment and prevention of endometriosis, for contraception, for hormonal therapy in perimenopausal and post-menopausal women, for the treatment of osteoporosis and for the treatment uterine fibroids and other menstrual-related disorders, such as dysfunctional uterine bleeding.