Liberality is More Explainable than PCA of Transcriptome for Vertebrate Embryo Development
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CC-BY-4.0
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This study demonstrates that the quantitative index Liberality, reflecting cellular differentiation and dedifferentiation, effectively tracks vertebrate embryo development time course transcriptome data, aligning with historically annotated stages.
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Abstract
Dimensional reduction approaches of genome scale data are widely used. Liberality is one of the approaches which is a quantitative index of cellular differentiation and dedifferentiation. Here, we analyzed a trend of liberality of time course transcriptome data on vertebrate embryo development. Historically annotated embryo developmental stages matched changes in the trend of liberality. Analyzing liberality of various biological phenomena would be beneficial.
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Source provenance
- europepmc
- last seen: 2026-05-20T01:45:00.602351+00:00
- unpaywall
- last seen: 2026-05-22T02:00:06.705733+00:00
License: CC-BY-4.0