The Comparative Evaluation of the Therapeutic Effects of Autologous Cytokine-Rich Serum and Platelet-Rich Plasma in an Experimental Endometriosis Model

Erol Karakaş, Mustafa Ermiş, Hanifi Erol, Gökhan Akçakavak, Nevzat Emre Aslan, Özhan Karataş
In: Research Square · 2025 · doi:10.21203/rs.3.rs-6874729/v1 · W4412753766
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Autologous cytokine-rich serum (ACRS) and platelet-rich plasma (PRP) both reduced endometriotic lesion scores, with ACRS showing superior anti-inflammatory effects but higher angiogenesis and fibrosis markers compared to PRP.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This preprint compares Autologous Cytokine-Rich Serum (ACRS) and Platelet-Rich Plasma (PRP) as autologous intraabdominal treatments in a surgically induced rat model of endometriosis, evaluating inflammation, angiogenesis, and myofibroblast activity. Thirty-six adult female Wistar Albino rats were assigned to groups receiving endometriosis plus either ACRS or PRP (or distilled water), and lesion tissues were excised for histopathological scoring and immunohistochemistry for TNF-α, IL-6, VEGFA, and α-SMA. Both ACRS and PRP significantly reduced histopathological scores versus the endometriosis-only group; ACRS produced greater reductions in TNF-α and IL-6, while also showing higher VEGFA and α-SMA expression than PRP, suggesting relatively stronger angiogenic and fibrotic responses. A major caveat is that this is an unreviewed preprint, and findings come from an experimental rat model rather than human outcomes. This paper is centrally about endometriosis — it tests ACRS versus PRP in an experimental endometriosis model and reports molecular and histopathological effects.

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endometriosis

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europepmc
last seen: 2026-06-15T06:13:43.845377+00:00
openalex
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License: CC0 · commercial use OK