MMP-9,EMMPRIN and VEGEF in plasma of women with endometriosis

Objective To study the significance of detection of EMMPRIN,MMP-9 and VEGF in plasma of women with endometriosis.Methods We measured the concentrations of EMMPRIN,MMP-9 and VEGF in plasma of women with endometriosis(n=70) and compared them with those in a control group(n=20),as assessed by enzyme-linked immunosorbent assay(ELISA).Results The concentrations of MMPRIN,MMP-9 and VEGF in the plasma of patients with endometriosis was higher than that in the control group(P 0.05).The same result appeared in advanced stage compared with early stage.Positive correlations between stage of disease with EMMPRIN,MMP-9 and VEGF were found(P 0.01,P =0.396).The concentrations of VEGF after treatment were significantly lower(P 0.05) in plasma of endometriosis patients.Conclusion These results suggest that EMMPRIN,MMP-9 and VEGF may play an important role in the pathogenesis of the disease.Detection of EMMPRIN,MMP-9 and VEGF,especially VEGF in plasma of women with endometriosis has important clinical significance.