Sound preferences in mice are sex-dependent

2024 · doi:10.1101/2024.08.04.606510
preprint OA: closed
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This study examined how early-life exposure to music, other non-music sounds, or silence during a critical period influences later sound preference behavior in mice, using behavioral testing a few weeks afterward. The authors found that music exposure affected preferences in a sex-dependent way: males largely preferred the exposed sound environment, whereas females showed only a weak reduction in what the authors describe as an innate aversion to sound. Neural activity in auditory cortex was suppressed in exposed versus naive mice for all exposure types, and in females there was a robust negative correlation between neural response and behavior that was not present in males. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

We investigated the impact of early exposure to sound and to silence on sound preferences later in life in mice. We exposed young mice during the critical periods to excerpts of music (first movement of Beethoven’s symphony no. 9), non-music sounds, or to silence. We tested the sound preference behavior a few weeks later. Music exposure affected mouse behavior in a sex- dependent manner: male mice largely preferred the environment to which they were exposed, while female mice showed a weak reduction in their seemingly inborn aversion to sound. The neural activity in auditory cortex was suppressed in exposed compared to naive mice, regardless of exposure type. Remarkably, a robust negative correlation was found between neural response and behavior in female, but not in male, mice.
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Abstract We investigated the impact of early exposure to sound and to silence on sound preferences later in life in mice. We exposed young mice during the critical periods to excerpts of music (first movement of Beethoven’s symphony no. 9), non-music sounds, or to silence. We tested the sound preference behavior a few weeks later. Music exposure affected mouse behavior in a sex- dependent manner: male mice largely preferred the environment to which they were exposed, while female mice showed a weak reduction in their seemingly inborn aversion to sound. The neural activity in auditory cortex was suppressed in exposed compared to naive mice, regardless of exposure type. Remarkably, a robust negative correlation was found between neural response and behavior in female, but not in male, mice. Competing Interest Statement The authors have declared no competing interest. Footnotes There was some error in the text.

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