Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome

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Case report: A four-year-old Egyptian boy presented with a maternal complaint that her child suffers from early loss of many teeth, presence of loose teeth along with an asymptomatic swelling related to the upper anterior area. The patient was diagnosed with PLS. A symptomatic management and prevention program was followed and the swelling was excised; afterwards diagnosed as peripheral ossifying fibroma. Conclusion: Early recognition and intervention for patients with PLS is essential to avoid the threat of being edentulous if left unmanaged." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/7-1420", "name": "Case Report: Clinical manifestation and dental management of Papillon-Lefèvre..." } } ] } Home Browse Case Report: Clinical manifestation and dental management of Papillon-Lefèvre... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Yousry YM, EL-Latif AEA and El-Gawad RYA. Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.12688/f1000research.16042.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Case Report Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] Yasmin Mohamed Yousry https://orcid.org/0000-0003-3372-5019 1 , Amr Ezzat Abd EL-Latif 1 , Randa Youssef Abd El-Gawad 1 Yasmin Mohamed Yousry https://orcid.org/0000-0003-3372-5019 1 , Amr Ezzat Abd EL-Latif 1 , Randa Youssef Abd El-Gawad 1 PUBLISHED 06 Sep 2018 Author details Author details 1 Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University, Cairo, Egypt Yasmin Mohamed Yousry Roles: Data Curation, Investigation, Writing – Original Draft Preparation Amr Ezzat Abd EL-Latif Roles: Project Administration, Supervision Randa Youssef Abd El-Gawad Roles: Supervision, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS Abstract Background: Papillon-Lefèvre syndrome (PLS) is considered a rare syndrome, which is characterized by the presence of palmar-plantar hyperkeratosis and aggressively progressing periodontitis that finally leads to premature loss of both deciduous and permanent teeth. Case report: A four-year-old Egyptian boy presented with a maternal complaint that her child suffers from early loss of many teeth, presence of loose teeth along with an asymptomatic swelling related to the upper anterior area. The patient was diagnosed with PLS. A symptomatic management and prevention program was followed and the swelling was excised; afterwards diagnosed as peripheral ossifying fibroma. Conclusion: Early recognition and intervention for patients with PLS is essential to avoid the threat of being edentulous if left unmanaged. READ ALL READ LESS Keywords Papillon – Lefèvre syndrome, Periodontitis, Premature tooth loss, Palmoplantar keratosis. Corresponding Author(s) Yasmin Mohamed Yousry ( [email protected] ) Close Corresponding author: Yasmin Mohamed Yousry Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2018 Yousry YM et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Yousry YM, EL-Latif AEA and El-Gawad RYA. Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.12688/f1000research.16042.1 ) First published: 06 Sep 2018, 7 :1420 ( https://doi.org/10.12688/f1000research.16042.1 ) Latest published: 06 Sep 2018, 7 :1420 ( https://doi.org/10.12688/f1000research.16042.1 ) Introduction Papillon-Lefèvre syndrome (PLS) is an autosomal recessive disorder that typically becomes apparent from one to five years of age, which coincides with the timing of eruption of primary dentition. The estimated prevalence of the syndrome is 1–4 cases per million individuals 1 . The exact etiopathogenesis of the syndrome is relatively unclear and different etiological factors have been suggested, such as immunologic, genetic or bacterial, but recently it was suggested that mutations of cathepsin C gene, which results in deficiency of cathepsin C enzymatic activity, to be the possible etiological factor. This was supported by the fact that expression of the cathepsin C gene occurs mainly in epithelial regions, such as the soles, palms and keratinized oral gingiva, which are the most affected areas in patients with PLS 2 . An important feature of the syndrome is the presence of palmoplantar hyperkeratosis; its onset usually occurs between the ages of one to four years and usually involves the palms of the hands and soles of the feet 3 . Another major feature is severe gingivostomatitis and periodontitis. Deciduous teeth usually erupt in normal sequence, timing and with normal structure and form, although it was reported that some cases may have microdontia and incomplete root formation 4 . First, the gingiva becomes inflamed and then rapid destruction of periodontium occurs. This is manifested in the form of redness and swelling in the gingiva with severe bone resorption and periodontal pockets. Patients usually suffer from looseness, drifting, migration, and exfoliation of teeth so that by the age of 4–5 years all primary teeth are prematurely exfoliated and the same cycle is repeated with permanent teeth 5 . A multidisciplinary approach for the management of cases with PLS is usually required and periodontal treatment, if started early, will decrease the rate of periodontal destruction 6 . We hereby report a rare case that, to the best of our knowledge, may be the first for a child with PLS together with peripheral ossifying fibroma lesion that is not a characteristic feature for the syndrome. Case report A four-year-old Egyptian boy presented to the Pediatric Dental Clinic, Faculty of Dentistry, Cairo University, suffering from premature loss of anterior teeth, friable and bleeding gums and swelling related to the upper anterior region. Medical history revealed absence of any medical problems; family history revealed that neither parents nor siblings had the same problem and the parents were not of consanguineous marriage. Examination of the palms of the hand revealed normal skin, while the soles of the feet revealed very slight hyperkeratosis ( Figure 1a,b ). Intraoral examination revealed severe gingival recession; inflammation especially in anterior region; aggressive periodontitis; mobility of maxillary left central incisor and canine, with swelling related to the maxillary right missed canine region extending toward occlusal surface. The swelling appeared as a solitary rounded lesion, with onset gradual for 2 months. The size of the swelling was 4×4 mm, and upon palpation it was not tender but slightly hemorrhagic ( Figure 2a,b ). Figure 1. Photographs of ( a ) the palms of the hands showing normal skin and ( b ) the soles of the feet showing very slight hyperkeratosis. Figure 2. Intraoral photographs showing ( a ) severe gingival recession and inflammation, especially in anterior region, and aggressive periodontitis; ( b ) swelling related to the maxillary right missed canine region extending toward occlusal surface. Radiographic examination showed severe destruction and loss of alveolar bone ( Figure 3 ). Lab investigations were normal ( Table 1 ). Figure 3. Panoramic radiograph showing severe destruction and loss of alveolar bone in both maxillary and mandibular arch, especially in the anterior region and anterior teeth appear as if floating in air without surrounding alveolar bone. Table 1. Lab investigations results showing that serum calcium and phosphorus level is normal, Alkaline phosphatase level is normal and the complete blood work is normal. Test name Results Units Reference range HB &indeses Haemoglobin 11.6 gm/dl 11.5 - 16.0 Red cell count 4.23 mil/cmm 4.0 – 5.6 Haematocrit (pcv) 36 % 36- 46 Red blood cell indices MCV 78 fL 77-95 MCH 27 pg 25 - 30 MCHC 30 % 30- 34 TLC & Differential White cell count 10.200 Thousand/cmm 4.0-13 Basophils 0 /cmm 0- 2 Eosinophils 1 /cmm 1 - 4 Staff 2 /cmm 0- 6 Segmented 40 /cmm 37- 75 Lymphocytes 50 /cmm 20-45 Monocytes 7 /cmm 2-10 PLT Platelets count 171 Thousand/cmm 150- 450 MPV 7.2 fL 6.5- 12 PDW 15.6 % 9 - 17 PCT 0.21 % 0.1 -0.5 P-LCR 14 % 13- 43 Clinical chemistry report ALP,serum 233 U/ l ( up to 640 ) Calcium (total) ,Serum 9.8 mg/dl (8.6- 10.2) Phosphorous 4.8 mg/dl ( 4.0- 7.0 ) Liver function tests Alkaline phosphatase 534 U/L 180- 1200 Taking into consideration the clinical features and investigations, a diagnosis of PLS was confirmed. Dental management of the case Conventional periodontal treatment in the form of scaling and root planning was performed. Antibiotic amoxicillin and metronidazole (250 mg, 3 times daily) for one week along with a mouth rinse (0.2% chlorhexidine gluconate, 10 mL twice daily) was prescribed to the patient 7 . Extraction of the maxillary left central and canine teeth was advised, but the parent refused even after the risk was explained of not extracting these loose teeth. After laboratory investigations, excisional biopsy of the swelling was done under antibiotic coverage and local anesthesia. Thorough curettage of the adjacent periodontal ligament and periosteum was carried out to prevent recurrence ( Figure 4 a,b ). Histopathological examination revealed the lesion as peripheral ossifying fibroma ( Figure 5 ). Figure 4. Photograph showing ( a ) removal of the swelling and ( b ) excisional biopsy of the swelling. Figure 5. Histopathological image showing evidence of calcifications in the hypercellular fibroblastic stroma confirming the lesion as peripheral ossifying fibroma. The patient was educated for oral hygiene and scheduled for a follow-up visit every month for scaling and checking the condition of the patient. The patient was followed up for 2 years during which loss of maxillary left central incisor occurred and extraction of loose upper left canine was done with no recurrence of the lesion ( Figure 6 ). The palms of the hands revealed no change, while examination of the soles of the feet showed slight increase in keratosis ( Figure 7 a,b ). Figure 6. Follow-up photograph after 2 years showing loss of more teeth with no recurrence of the lesion. Figure 7. Follow-up photographs after 2 years showing ( a ) absence of change in the palms of the feet and ( b ) slight increase in keratosis in the soles of the feet. Discussion Papillon-Lefèvre syndrome (PLS) is inherited as an autosomal recessive disorder where the parents of the patient with PLS should have the autosomal gene for the syndrome in order to manifest in their offspring. However, in the present case the parents are clinically healthy with no family history of the disorder. Studies have shown that when carrier parents for the affected gene mate, there is a 25% chance that they have an affected offspring 8 . This could explain the reason that the child had the syndrome although his parents were clinically healthy. The intraoral appearance of severe aggressive periodontitis, which appears at the age of 3–4 years following complete eruption of primary teeth as seen in this case, concurred with observations in similar reported cases in the literature where primary teeth develop normally but eruption is accompanied with severe gingivitis followed by periodontal destruction, resulting in early loss of primary teeth 9 . Ullbro et al. 10 suggested that the two major components of PLS (palmar-plantar hyperkeratosis and aggressively progressing periodontitis) are not related to each other, as these authors found absence of association between the degree of hyperkeratosis and severity of periodontitis. This is in accordance with our case as the degree of hyperkeratosis is slight although periodontitis is severe. Acrodynia, hypophosphatasia and cyclic neutropenia are differential diagnoses of PLS. This case is not acrodynia due to absence of erythrocyanosis, insomnia, and teeth erupting prematurely with dystrophic enamel. It is not hypophosphatasia due to normal level of alkaline phosphatase and it is not cyclic neutropenia, as in cyclic neutropenia the palmoplantar hyperkeratosis is absent 11 . Management of cases with PLS should be multidisciplinary with dentists, dermatologists and pediatricians. Early diagnosis and management of oral problems help in reducing the undesirable sequelae of the syndrome. Following the treatment protocol for periodontal therapy proposed by Ullbro et al. 10 periodontal deterioration can be minimized. This includes: scaling and polishing; giving systemic antibiotics aimed at eliminating the reservoir of causative organisms; extraction of teeth having poor prognosis; giving instructions for maintenance of oral hygiene; and continuous monitoring and frequent recall appointments. In the present case an early diagnosis of PLS and a treatment protocol minimized the periodontal deterioration and prevented further loss of other teeth. The parents were satisfied by these results. Consent Written informed consent for publication of the clinical details and images was obtained from the patient's mother. Data availability All data underlying the results are available as part of the article and no additional source data are required. Grant information The author(s) declared that no grants were involved in supporting this work. Faculty Opinions recommended References 1. Hattab FN, Rawashdeh MA, Yassin OM, et al. : Papillon-Lefèvre syndrome: a review of the literature and report of 4 cases. J Periodontol. 1995; 66 (5): 413–420. PubMed Abstract | Publisher Full Text 2. Hart TC, Hart PS, Bowden DW, et al. : Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome. J Med Genet. 1999; 36 (12): 881–887. PubMed Abstract | Free Full Text 3. Janjua SA, Khachemoune A: Papillon-Lefèvre syndrome: case report and review of the literature. Dermatol Online J. 2004; 10 (1): 13. PubMed Abstract 4. Fahmy MS: Papillon-Lefevre syndrome: Report of four cases in two families with a strong tie of consanguinity. A clinical, radiographic, haematological and genetic study. J Oral Med. 1987; 42 : 263–268. 5. Mahajan VK, Thakur NS, Sharma NL, et al. : Papillon-Lefèvre syndrome. Indian Pediatr. 2003; 40 (12): 1197–1200. PubMed Abstract 6. Ashri NY: Early diagnosis and treatment options for the periodontal problems in Papillon-Lefèvre syndrome: a literature review. J Int Acad Periodontol. 2008; 10 (3): 81–6. PubMed Abstract 7. Kellum RE: Papillon-Lefèvre syndrome in four siblings treated with etretinate. A nine-year evaluation. Int J Dermatol. 1989; 28 (9): 605–608. PubMed Abstract | Publisher Full Text 8. Kulasekara B: Hyperkeratosis palmoplantaris (Papillon-Lefèvre syndrome). A case report. Trop Geogr Med. 1988; 40 (3): 257–8. PubMed Abstract 9. Hattab FN, Amin WM: Papillon-Lefèvre syndrome with albinism: a review of the literature and report of 2 brothers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 100 (6): 709–16. PubMed Abstract | Publisher Full Text 10. Ullbro C, Crossner CG, Nederfors T, et al. : Dermatologic and oral findings in a cohort of 47 patients with Papillon-Lefèvre syndrome. J Am Acad Dermatol. 2003; 48 (3): 345–351. PubMed Abstract | Publisher Full Text 11. Nagaveni NB, Suma R, Shashikiran ND, et al. : Papillon-Lefevre syndrome: Report of two cases in the same family. J Indian Soc Pedod Prev Dent. 2008; 26 (2): 78–81. PubMed Abstract | Publisher Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 06 Sep 2018 ADD YOUR COMMENT Comment Author details Author details 1 Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University, Cairo, Egypt Yasmin Mohamed Yousry Roles: Data Curation, Investigation, Writing – Original Draft Preparation Amr Ezzat Abd EL-Latif Roles: Project Administration, Supervision Randa Youssef Abd El-Gawad Roles: Supervision, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 06 Sep 2018, 7:1420 https://doi.org/10.12688/f1000research.16042.1 Copyright © 2018 Yousry YM et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Yousry YM, EL-Latif AEA and El-Gawad RYA. Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.12688/f1000research.16042.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 06 Sep 2018 Views 0 Cite How to cite this report: Ezzat Sabet N. Reviewer Report For: Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.5256/f1000research.17520.r38617 ) The direct URL for this report is: https://f1000research.com/articles/7-1420/v1#referee-response-38617 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 05 Oct 2018 Noha Ezzat Sabet , Department of Orthodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt Approved VIEWS 0 https://doi.org/10.5256/f1000research.17520.r38617 The case report is quite informative, well written. Clearly and easily understood. The subject is addressed obviously and the diagnostic procedures are to clarify the point of interest. The results are professionally discussed and the conclusion that calls for early ... Continue reading READ ALL The case report is quite informative, well written. Clearly and easily understood. The subject is addressed obviously and the diagnostic procedures are to clarify the point of interest. The results are professionally discussed and the conclusion that calls for early diagnosis to minimize the progress of dental loss and periodontal deterioration is of great interest. I think the authors should have clarified did they or did not restore the missing teeth. Also I would recommend a longer time of follow up to the case to ensure the condition of the permanent teeth after their eruption and to assure that its eruption time is not affected by the periodontal condition. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Ezzat Sabet N. Reviewer Report For: Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.5256/f1000research.17520.r38617 ) The direct URL for this report is: https://f1000research.com/articles/7-1420/v1#referee-response-38617 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: ElShafei MM. Reviewer Report For: Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.5256/f1000research.17520.r38401 ) The direct URL for this report is: https://f1000research.com/articles/7-1420/v1#referee-response-38401 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 19 Sep 2018 Marwa Mokbel ElShafei , Faculty of Dentistry, Misr International University, Cairo, Egypt Approved VIEWS 0 https://doi.org/10.5256/f1000research.17520.r38401 The case report is concerned about a case of a 4 year-old boy suffering from looseness of some teeth and loss of many others. Palmar-plantar hyperkeratosis is noticed on his palms and soles, although not severe but well detected. Aggressive ... Continue reading READ ALL The case report is concerned about a case of a 4 year-old boy suffering from looseness of some teeth and loss of many others. Palmar-plantar hyperkeratosis is noticed on his palms and soles, although not severe but well detected. Aggressive progressive periodontitis is diagnosed as the cause of loss of teeth. A painless swelling is found on the gingiva related to the upper anterior teeth; this swelling was excised and diagnosed as a peripheral ossifying fibroma. Follow up and scheduled scaling and polishing to prevent sequel of aggressive periodontitis is the management chosen for this patient. Another key word to be added "peripheral ossifying fibroma" Another photomicrograph needed to confirm presence of calcification and a possible immunohistochemical staining with cathepsin C and with calcitonin is an option. State how long did the monthly follow up remained. How did you restore the lost permanent central incisor and how would you prevent future loss and looseness of teeth due to the syndrome's periodontitis. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT ElShafei MM. Reviewer Report For: Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.5256/f1000research.17520.r38401 ) The direct URL for this report is: https://f1000research.com/articles/7-1420/v1#referee-response-38401 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 06 Sep 2018 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 Version 1 06 Sep 18 read read Marwa Mokbel ElShafei , Misr International University, Cairo, Egypt Noha Ezzat Sabet , Ain Shams University, Cairo, Egypt Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2018 Ezzat Sabet N. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 05 Oct 2018 | for Version 1 Noha Ezzat Sabet , Department of Orthodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt 0 Views copyright © 2018 Ezzat Sabet N. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The case report is quite informative, well written. Clearly and easily understood. The subject is addressed obviously and the diagnostic procedures are to clarify the point of interest. The results are professionally discussed and the conclusion that calls for early diagnosis to minimize the progress of dental loss and periodontal deterioration is of great interest. I think the authors should have clarified did they or did not restore the missing teeth. Also I would recommend a longer time of follow up to the case to ensure the condition of the permanent teeth after their eruption and to assure that its eruption time is not affected by the periodontal condition. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Ezzat Sabet N. Peer Review Report For: Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.5256/f1000research.17520.r38617) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/7-1420/v1#referee-response-38617 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2018 ElShafei M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 19 Sep 2018 | for Version 1 Marwa Mokbel ElShafei , Faculty of Dentistry, Misr International University, Cairo, Egypt 0 Views copyright © 2018 ElShafei M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The case report is concerned about a case of a 4 year-old boy suffering from looseness of some teeth and loss of many others. Palmar-plantar hyperkeratosis is noticed on his palms and soles, although not severe but well detected. Aggressive progressive periodontitis is diagnosed as the cause of loss of teeth. A painless swelling is found on the gingiva related to the upper anterior teeth; this swelling was excised and diagnosed as a peripheral ossifying fibroma. Follow up and scheduled scaling and polishing to prevent sequel of aggressive periodontitis is the management chosen for this patient. Another key word to be added "peripheral ossifying fibroma" Another photomicrograph needed to confirm presence of calcification and a possible immunohistochemical staining with cathepsin C and with calcitonin is an option. State how long did the monthly follow up remained. How did you restore the lost permanent central incisor and how would you prevent future loss and looseness of teeth due to the syndrome's periodontitis. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? Yes Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) ElShafei MM. Peer Review Report For: Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome [version 1; peer review: 2 approved] . F1000Research 2018, 7 :1420 ( https://doi.org/10.5256/f1000research.17520.r38401) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. 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