Hylocereus Polyrhizus Peel Ethanol Extract- the Potential Effect to Tumor Necrosis Factor-Α, Macrophage, and Matrix Metalloproteinase-9 in Endometriosis Mice

ANINDYA HAPSARI, 011514653001; Hendy Hendarto, 090315218 D; Widjiati

Hylocereus Polyrhizus Peel Ethanol Extract- the Potential Effect to Tumor Necrosis Factor-Α, Macrophage, and Matrix Metalloproteinase-9 in Endometriosis Mice

ANINDYA HAPSARI, 011514653001, Hendy Hendarto, 090315218 D, Widjiati

2017 · W7000973618

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Abstract

On endometriosis, macrophage and TNF-α was found in higher concentration. Tumor Necrosis Factor-α activates NF-κB pathway and increase the expression of MMP-9’s gen. NF-κB pathway can be blocked by Hylocereus polyrhizus peel. The objective of this study was to know the effect of Hylocereus polyrhizus peel ethanol extract at dose 0,25; 0,5 mg/gram BW/day; and 1 mg/gram on TNF-α concentration, number of macrophage, and MMP-9 expression on mouse model of endometriosis. This study was a laboratory experimental research. Thirty female mice were used as samples and divided into 5 groups: 1 positive control, 1 negative control, and 3 treatment groups. Positive control and treatment groups were induced as model of endometriosis for 14 days. The next 14 days, Na-CMC 0,5% was given to both control groups, while Hylocereus polyrhizus peel ethanol extract dose 0,25; 0,5 mg/gram BW/day; and 1 mg/gram were given to treatment groups orally. Peritoneum fluid and endometriosis lesion were examined. There were significantly differences on TNF-α concentration (p=0.021), number of macrophage (p=0.00), and MMP-9 expression (p=0.002) among control groups and treatment groups. TNF-α concentrations were higher on treatment groups. Hylocereus polyrhizus peel ethanol extract can be used as alternative therapy for attenuating the alteration of macrophage and MMP-9 in endometriosis disease

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Nomor ISSN LEaBAR HAS:L PENILAIAN SEJAWAT SEB:DANG ATAU PEER R¦ KARYAiLM:AH:JURNAL:LMIAa Hylocereus Polyrhlzus Peel Ethanol Extracte the Potenual EfFct to ttumor Necrosis Fåtor]A, Macrophage,and Matrix Metallop_teinase-9in Endometaosls Mice 3(19al]Anindya Hapsan,Hendy Hendarto,Widilal(Status Co Authoã Penulis ke 2 dari 3 penulis @ D Volume, Nomor, bulan, tahun Penerbit DOlartikel AlamatWeb Jumal 10-no]3/ g, Tenndek di ScimagOr/Thomson i SCOPUS Q3 ReuterlSI KnoMedge atau dl : Joumal oflntemational Dental and Medical Research i 1309-100X i Vol.10 No.03 tahun 2017 Page.1070-1073 l ECttODERMAL DYSPLASIA GROUP\URKEY : htpvMttw.lidmr.COm40umal/contents]ofrildmm2017]vog Jumal llmiah lntemasional Bereputasi Jumal llmiah lntemasional Jumal llmiah Nasional Terakreditasi Jumal llmiah Nasional Tidak Terakreditasi Jumal llmiah Nasional terindeks di DOAJ, CABI, COPERNICUS dan tainnya S Hasil Penilaian Peer Review: Komponen yang dinilai Nilai Maksimal Juma!amiah Ni:ai ReYewer yang Diperoleh lntemasional Bereputasi NilaiMax.40 lntemasional NilaiMax. 30 Nasional Terakreditasi Nilai MaxB25 Nasional Tidak Terakreditasi Nilai Max,10 a, Kelengkapan unsurisilumalamiah (10%) 4 g5 g Ruang lingkup dan kedalaman pembahasan (30%) 12 lXA C. Kecukupan dan kemutahiran data/infomasl dan metoddogi(300/Ol 12 12 d. Kelengkapan unsur dan kualitas penerbit iumal(30%) 12 12 Tota:={100%} 40 3g,^ Nilal Pengusul= t4,9 Catatan Penilaian paper oleh Reviewer : 1) Kelenokanan unsur isi iumal ¢ Ac g cêi AcÝ 2R Ruanoúnakuo dan KedJaman Dembahasan._Rc]r_¨ Á __lP]ãÛARó,(10- )æÉVL%1::|%3l KecukuDan dan kemutakhiran data/inforrnasi dan metodolool cccc c EEccccccc]\ccccccccc] 4)Kelenokaoanunsurdankualitasterbitarr/iumatWry?4&=#4 Surabaya,21 Pebruari 2019 Reviewer 2 P_f,H.Samsulhadi,dr.,Sp.OG(K) NIP,194407072015086101 Unl Ketta:Depmemen obstetri dan Ginekologi Fakuttas Kedoktem UnhâJãJGÂs Aidangga

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