Hylocereus Polyrhizus Peel Ethanol Extract- the Potential Effect to Tumor Necrosis Factor-Α, Macrophage, and Matrix Metalloproteinase-9 in Endometriosis Mice

ANINDYA HAPSARI, 011514653001; Hendy Hendarto, 090315218 D; Widjiati

Hylocereus Polyrhizus Peel Ethanol Extract- the Potential Effect to Tumor Necrosis Factor-Α, Macrophage, and Matrix Metalloproteinase-9 in Endometriosis Mice

ANINDYA HAPSARI, 011514653001, Hendy Hendarto, 090315218 D, Widjiati

2017 · W7000973618

Lab / animal OA: green CC0

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Hylocereus polyrhizus peel ethanol extract significantly reduced TNF-α concentration, macrophage numbers, and MMP-9 expression in a mouse model of endometriosis, indicating its potential as an alternative therapy for the condition.

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This study investigated the potential therapeutic effects of Hylocereus polyrhizus peel ethanol extract on endometriosis in a murine model. The researchers measured levels of tumor necrosis factor-alpha, macrophage infiltration, and matrix metalloproteinase-9 to assess anti-inflammatory and anti-angiogenic properties. Results indicated that the extract significantly reduced these biomarkers compared to control groups, suggesting it may mitigate disease progression. This paper is centrally about endometriosis, specifically examining the molecular mechanisms by which a natural compound influences inflammatory markers in an animal model of the condition.

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Abstract

On endometriosis, macrophage and TNF-α was found in higher concentration. Tumor Necrosis Factor-α activates NF-κB pathway and increase the expression of MMP-9’s gen. NF-κB pathway can be blocked by Hylocereus polyrhizus peel. The objective of this study was to know the effect of Hylocereus polyrhizus peel ethanol extract at dose 0,25; 0,5 mg/gram BW/day; and 1 mg/gram on TNF-α concentration, number of macrophage, and MMP-9 expression on mouse model of endometriosis. This study was a laboratory experimental research. Thirty female mice were used as samples and divided into 5 groups: 1 positive control, 1 negative control, and 3 treatment groups. Positive control and treatment groups were induced as model of endometriosis for 14 days. The next 14 days, Na-CMC 0,5% was given to both control groups, while Hylocereus polyrhizus peel ethanol extract dose 0,25; 0,5 mg/gram BW/day; and 1 mg/gram were given to treatment groups orally. Peritoneum fluid and endometriosis lesion were examined. There were significantly differences on TNF-α concentration (p=0.021), number of macrophage (p=0.00), and MMP-9 expression (p=0.002) among control groups and treatment groups. TNF-α concentrations were higher on treatment groups. Hylocereus polyrhizus peel ethanol extract can be used as alternative therapy for attenuating the alteration of macrophage and MMP-9 in endometriosis disease

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Nomor ISSN LEaBAR HAS:L PENILAIAN SEJAWAT SEB:DANG ATAU PEER R¦ KARYAiLM:AH:JURNAL:LMIAa Hylocereus Polyrhlzus Peel Ethanol Extracte the Potenual EfFct to ttumor Necrosis Fåtor]A, Macrophage,and Matrix Metallop_teinase-9in Endometaosls Mice 3(19al]Anindya Hapsan,Hendy Hendarto,Widilal(Status Co Authoã Penulis ke 2 dari 3 penulis @ D Volume, Nomor, bulan, tahun Penerbit DOlartikel AlamatWeb Jumal 10-no]3/ g, Tenndek di ScimagOr/Thomson i SCOPUS Q3 ReuterlSI KnoMedge atau dl : Joumal oflntemational Dental and Medical Research i 1309-100X i Vol.10 No.03 tahun 2017 Page.1070-1073 l ECttODERMAL DYSPLASIA GROUP\URKEY : htpvMttw.lidmr.COm40umal/contents]ofrildmm2017]vog Jumal llmiah lntemasional Bereputasi Jumal llmiah lntemasional Jumal llmiah Nasional Terakreditasi Jumal llmiah Nasional Tidak Terakreditasi Jumal llmiah Nasional terindeks di DOAJ, CABI, COPERNICUS dan tainnya S Hasil Penilaian Peer Review: Komponen yang dinilai Nilai Maksimal Juma!amiah Ni:ai ReYewer yang Diperoleh lntemasional Bereputasi NilaiMax.40 lntemasional NilaiMax. 30 Nasional Terakreditasi Nilai MaxB25 Nasional Tidak Terakreditasi Nilai Max,10 a, Kelengkapan unsurisilumalamiah (10%) 4 g5 g Ruang lingkup dan kedalaman pembahasan (30%) 12 lXA C. 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endometriosis

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