Polymer modified anti-angiogenic serpins
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Researchers developed polymer-modified anti-angiogenic serpins with extended half-lives to inhibit pathological angiogenesis in conditions including endometriosis, diabetic retinopathy, and cancer.
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Abstract
Methods and compositions for improving the angiogenesis-inhibitory effect of an anti-angiogenic serpin, or anti-angiogenic fragment thereof, by covalently linking a polymer moiety to the serpin such that the biological half-life of the serpin is extended for inhibition of diseases having a pathological angiogenic component including diabetic retinopathy, age-related macular degeneration, rheumatoid arthritis, endometriosis, psoriasis, juvenile hemangioma, and cancer.
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- europepmc
- last seen: 2026-07-14T06:08:30.651965+00:00