MSCs play a vital function in Tibial cortex transverse transport surgery

Background: Tibial cortex transverse transport (TTT) has a good clinical effect in the treatment of diabetic foot, and the postoperative indexes of patients have been significantly improved. However, the mechanism of TTT on the increased expression of angiogenesis related factors and wound healing is still unclear Methods: Diabetic foot model with tibial bone marrow purging was established to observe the effect of MSCs combined with TTT on angiogenesis and wound healing. The angiogenesis and wound healing process was evaluated by vascular perfusion, immunohistochemistry and Western blotting. Results: After treatment with TTT surgery and MSCS injected into the myeloablated bone marrow cavity, the results showed faster wound healing and better skin recovery, angiography results showed that more new blood vessels were observe, and immunohistochemical staining and Western blotting detection also showed that TTT technology promoted CD31 expression through MSCs of the bone marrow cavity. Conclusion: MSCs in the bone marrow cavity play a vital function in TTT surgery.