Multiple endometrial stromal nodules with sparce cysts and glands in the lung – A nodular variation of endometriosis that may mimic metastases of sarcoma

M. Huber, Huber M, Wierrani F, F Wierrani, F. Wierraní, Böhm G, G Böhm, Gerhard Böhm, Hauck H, Herwig Hauck, H Hauck, Felix Lintnerl, Lintner F, F Lintner, Werner Grünberger, W Grünberger, Grünberger W
Pathology, research and practice · 1999 · vol. 195(1) , pp. 59–64 · doi:10.1016/s0344-0338(99)80099-5 · PMID:10048096 · W2080021176
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This case study describes a rare nodular variation of pulmonary endometriosis, characterized by endometrial stromal cells, sparse cysts and glands, and specific immunohistochemical markers, which can mimic sarcoma metastases.

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Abstract

We report an unusual case of a nodular variation of pulmonary endometriosis. To our knowledge, there is no previous report on a morphological investigation of this entity. The etiology of this rare condition is still a matter of discussion. The well-circumscribed nodular mass is composed of cells identical to, or closely resembling, those of endometrial stroma containing sparse cysts and glands. Immunohistochemically, the cells showed an extensive co-expression of cytokeratin AE1/AE3 and vimentin and were highly positive for progesterone receptor (PRICA) and estrogen receptor (ERICA). Cells lining the cysts and glands as a monolayer were reactive for Ber-Ep4, cytokeratin Pan and cytokeratin AE1/AE3 and negative to all other markers used including PRICA and ERICA. The differential diagnosis of this entity included fibrous tumor of the pleura and metastatic low-grade-endometrial-stromal-sarcoma. The morphological findings are correlated with immunohistochemical studies and results of cell image analysis. This study details the clinicopathological features of the nodular variation of pulmonary endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometrial Neoplasms Endometriosis Lung Diseases Sarcoma, Endometrial Stromal Adult Biomarkers, Tumor Biomarkers, Tumor Cysts Cysts Diagnosis, Differential DNA DNA Endometrial Neoplasms Endometriosis Endometriosis Female Fibroma Fibroma Humans Image Cytometry

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