The Role of Systemic Immune-inflammation Index in the Severity of Hyperemesis Gravidarum

Abstract Purpose Hyperemesis gravidarum (HEG) is one of the most common causes of hospitalization in early pregnancy. Complete blood count parameters can be used as inflammatory markers in patients with HEG. We aimed to investigate the Systemic Immune-Inflammation Index (SII) in predicting the severity of HEG. Methods This cross-sectional study was performed with pregnant women who were hospitalized in the Perinatology Department, Ankara City Hospital, with the diagnosis of HEG. The study data were obtained from the electronic database of Ankara City Hospital. The study parameters were calculated from complete blood count tests and urine analysis. Results A total of 469 pregnant women diagnosed with HEG were included in this study. There was a positive correlation between the increased degree of ketonuria and SII. The cut-off value of SII for predicting the severity of HEG was 1071.8, sensitivity and specificity were 59% and 59%, respectively. The cutoff value of SII to predict the length of hospitalization was 1073.6, p= 0.039; sensitivity and specificity were 56.3% and 55.5%, respectively. Conclusions Considering the positive relationship between ketonuria and inflammation markers, the evaluation of SII in pregnant women with HEG may facilitate the clinical management of these patients.