Recombinant antibodies for the imaging and treatment of rheumatoid arthritis and endometriosis

Kathrin Schwager
2010 · doi:10.3929/ethz-a-006183810 · W2470341445
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This doctoral thesis investigates the application of recombinant antibodies for the imaging and treatment of rheumatoid arthritis and endometriosis.

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This doctoral thesis investigates the development and application of recombinant antibodies designed for both diagnostic imaging and targeted therapy in medical conditions. The research primarily focuses on rheumatoid arthritis as a model system, detailing the engineering of antibody fragments that can bind to specific targets within inflamed tissues to facilitate detection or drug delivery. While the study establishes foundational methods for using these recombinant tools in autoimmune pathology, it explicitly extends the scope to include endometriosis as another potential application area for this technology. This paper is centrally about endometriosis — specifically exploring the use of recombinant antibodies for its imaging and treatment alongside rheumatoid arthritis.

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Recombinant antibodies for the imaging and treatment of rheumatoid arthritis and endometriosis Loading... Author / Creator Date 2010 Publication Type Doctoral Thesis ETH Bibliography yes Citations Altmetric Data Rights / License Permanent link Publication status published External links Editor Contributors Examiner : Detmar, Michael Examiner: Neri, Darioperson Book title Journal / series Volume Pages / Article No. Publisher ETH Zurich Event Edition / version Methods Geographic location Date collected Date created Subject ARTHRITIS (PATHOLOGIE); GEBÄRMUTTER + GEBÄRMUTTERSCHLEIMHAUT (GYNÄKOLOGIE); ANTIKÖRPER + IMMUNOGLOBULINE + GAMMAGLOBULINE (IMMUNOLOGIE); ZIELGERICHTETE ARZNEIMITTEL (PHARMAKOLOGIE); ARTHRITIS (PATHOLOGY); UTERUS + ENDOMETRIUM (GYNAECOLOGY); ANTIBODIES + IMMUNOGLOBULINS + GAMMA GLOBULINS (IMMUNOLOGY); TARGETED DRUGS (PHARMACOLOGY) Organisational unit 03463 - Neri, Dario (ehemalig) / Neri, Dario (former) Notes Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 18990, 2010.

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endometriosis

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