Clinical study on the correlation between nuclear factor- κB,macrophage migration inhibitory factor and endometriosis

Objective: To explore the clinical correlation between nuclear factor-κB( NF-κB),macrophage migration inhibitory factor( MIF) and endometriosis. Methods: RT- PCR was used to detect NF- κB and MIF mRNA levels in eutopic endometrium of 30 patients without endometriosis,eutopic endometrium and ectopic endometrium of 68 patients with endometriosis; then the results were compared; the correlation between NF- κB,MIF mRNA levels and endometriosis in ectopic endometrium of patients with endometriosis was analyzed. Results: There were statistically significant differences in NF- κB and MIF mRNA levels between ectopic endometrium of patients with endometriosis and eutopic endometrium of patients without endometriosis( P 0. 01); there were statistically significant differences in NF- κB and MIF mRNA levels among patients with endometriosis of different clinical phases( P 0. 01),NF- κB and MIF mRNA levels increased with clinical stages( P 0. 01); the results of correlation analysis showed that there were positive correlations between NF- KB and MIF mRNA level,NF- KB level and clinical stages of endometriosis,MIF mRNA level and clinical stages of endometriosis,respectively( P 0.01). Conclusion: NF-κB and MIF play important roles in occurrence and development of endometriosis,which probably become to be new treatment targets of endometriosis.