Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Abstract Background: Previous studies proved that AGT gene polymorphisms were associated with the serum lipids metabolism; however, it is not clear whether AGT rs2493132 increases the risk of NAFLD and CAD. This study was designed to investigate the relationship between AGT rs2493132 gene polymorphism and the developing risk of NAFLD and CAD in Chinese Han population.Methods: A total of 142 NAFLD patients, 109 NAFLD + CAD patients, and 246 health controls were included in this study. PCR method was used to measure AGT genotype. The anthropometric and clinical data were measured in clinical laboratory department of Qingdao Municipal Hospital. Statistical analyzes were conducted using the SPSS statistical software, version 21.0. Results: The AGT rs2493132 CT + TT genotype was an important risk factor for CAD in patients with NAFLD (OR = 1.785; 95%CI: 1.061-3.003; P = 0.029), and the risk of CAD in patients with NAFLD was still marked after adjusted for gender, age, and BMI (OR = 4.718; 95%CI: 1.502-14.824; P = 0.008). The T allele of AGT rs2493132 also significantly increased the risk of CAD in NAFLD patients (OR = 2.436; 95% CI: 1.184-5.011, P = 0.016) after adjusted for age, gender, and BMI. In addition, AGT rs2493132 T allele carriers possess the higher TC and LDL levels compared to the non-carriers in all the participants (Both P < 0.05).Conclusions: AGT rs2493132 CT + TT genotype and T allele significantly increased the developing risk of CAD in the patients with NAFLD in Chinese Han population. AGT rs2493132 T allele associated with the increased serum TC and LDL levels.