Intranasal LHRH agonist combined periodically with a progestogen for contraception

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This study evaluated intranasal LHRH agonist combined periodically with a progestogen for contraception, noting its effectiveness and side effects.

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This paper describes the use of an intranasal LHRH (GnRH) agonist administered periodically in combination with a progestogen as an antiovulatory contraceptive approach, building on prior studies of intermittent LHRH agonist dosing and progestogen-induced bleeding. At a high level, the work focuses on endocrine and reproductive outcomes such as inhibition of ovulation, cyclic ovarian activity, and endometrial responses associated with different intermittent regimens combined with oral progestogens, with attention to regimen length and monitoring findings. A major caveat is that the evidence base is largely drawn from and contextualized by earlier trials across multiple formulations and dosing schedules, and the contraception-focused design does not establish broader gynecologic efficacy beyond reproductive endpoints. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via keyword match in the upstream search index.

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Fourteen-day versus twenty-one-day regimens of intermittent intranasal luteinizing hormone-releasing hormone agonist combined with an oral progestogen as antiovulatory contraceptive approach.J. Clin. Endocrinol. Metab.,63, 1379–1385 LemayA., FaureN. and BastideA. (1987). Ovarian sonographic findings during intermittent intranasal luteinizing hormone-releasing hormone agonist sequentially combined with an oral progestogen as antiovulatory contraceptive approach.Fertil. Steril.,47, 60–66 LemayA., JeanC. and FaureN. (1987). Endometrial histology during intermittent intranasal luteinizing hormone-releasing hormone (LH-RH) agonist sequentially combined with an oral progestogen as an antiovulatory contraceptive approach.Fertil. Steril.,48, 775–782 GeisthovelF., JenneD., WieackerP. and BreckwoldtM. (1987). Cyclic administration of an LHRH analogue and of progesterone in risk patients to oral contraceptives.Contraception,36, 459–469 Geisthovel, F., Wieacker, P., Greif, M. and Breckwoldt, M. (1989). Buserelin and progesterone (P) in risk patients to oral contraceptives (OC). The XIII World Congress on Fertility and Sterility, Marrakesh, October 1989, p. 563 (Abstr.) Birkhäuser, M.H., Witthaus, E., Werner, I. and Huber, P. (1989). Contraception by a cyclic buserelin/gestagen-combination: result of 410 contraceptive cycles. Presented at the International Symposium entitled: ‘The present place of LHRH analogues in gynaecology’, Brussels Congress Centre, Belgium, June 9–10, 1989 SchumacherT., ZwirnerM., UnterbergH., PohlC., KellerE. and SchindlerA.E. (1984). Effects of the LHRH-analogue buserelin given discontinuously as a contraceptive on ovarian cycle and lipometabolism.Neuroendocrinol. Lett.,6, 267–272 LemayA. and Dodin DewaillyS. (1989). Long-term use of the low dose LHRH analogue combined with monthly medroxyprogesterone administration.Horm. Res.,32, 141–145 Author information Authors and Affiliations Rights and permissions About this article Cite this article Lemay, A. Intranasal LHRH agonist combined periodically with a progestogen for contraception. Adv Contracept 5, 253–262 (1989). https://doi.org/10.1007/BF01890898 Issue date: DOI: https://doi.org/10.1007/BF01890898

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endometriosis

MeSH descriptors

Buserelin Contraceptive Agents, Female Medroxyprogesterone Administration, Intranasal Buserelin Buserelin Contraceptive Agents, Female Drug Evaluation Endometriosis Endometriosis Female Humans Medroxyprogesterone Medroxyprogesterone Menstruation Disturbances Menstruation Disturbances

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